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Trazodone is available as a 50 mg, 100 mg, 150 mg, and 300 mg oral tablet.

Trazodone is an atypical antidepressant and is used to treat major depressive disorder (MDD).

Trazodone is an atypical antidepressant. More specifically, it’s considered a serotonin antagonist and reuptake inhibitor (SARI). The exact way it works to improve your mood isn’t well-understood. But it’s thought to affect the levels of serotonin in the brain, which are chemicals involved in regulating your mood.

Trazodone is typically taken by mouth with starting dose of 150 mg divided into smaller doses and taken throughout the day to treat depression. Your physician might raise your dose slowly over time to a maximum dose of 400 mg daily.

Trazodone is a safe and effective treatment when used for FDA licensed indications. However, like all medications, they may give you unwanted side effects. You should always discuss potential side effects with your physician to ensure the medication is suitable and right for you. You should not use this medication if you have taken an MAOI within the past 14 days.

Common side effects of Trazodone include:

• Sleepiness
• Dry mouth
• Dizziness or lightheadedness
• Headache
• Blurred vision
• Nausea or vomiting

Serious side effects are rare with Trazodone. Contact your healthcare provider immediately if you experience any of the following.

• Suicidal thoughts or behaviors
• Serotonin syndrome: fast heart rate, dizziness, sweating, flushing, tremor (shakiness), muscle stiffness, muscle twitching or spasms, uncoordinated movement, distress, seizures, distress, hallucinations, coma
• Abnormal heart rhythm (QT prolongation): chest pounding, short of breath, chest pain, feeling faint or lightheaded
• Severe bleeding: bruising that doesn’t improve, black-colored stools, pink or red-colored urine, coughing up or vomiting blood, or unusual bleeding from the nose or gums
• Low blood sodium levels: nausea, fatigue, headache, confusion, disoriented, hallucinations (seeing things that aren’t real), seizures, unconsciousness

The following medications may interact with Trazodone:

• CNS Depressants – Trazodone may enhance effects of alcohol, barbiturates, or other CNS depressants
• CYP3A4 Inhibitors – Consider Trazodone dose reduction based on tolerability
• CYP3A4 Inducers – Increase in Trazodone dosage may be necessary
• Digoxin or Phenytoin – Monitor for increased digoxin or phenytoin serum levels
• Warfarin – Monitor for increased or decreased prothrombin time

Various FDA-approved generic manufacturers

Trazodone may cause fetal harm based on animal studies. You should talk to your healthcare provider before taking this medication if you are pregnant.

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