TrazodonePrices, Coupons & Savings

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*Based on the difference between the U&C price submitted and the price the patient paid, as of April 2023.

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  2. Trazodone
    Generic for Desyrel
    30 tablets $4.8 USD
    Save $10.50
  3. Trazodone
    Generic for Desyrel
    30 tablets $4.8 USD
    Save $10.50
  4. Trazodone
    Generic for Desyrel
    60 tablets $6 USD
    Save $24.60
  5. Trazodone
    Generic for Desyrel
    420 tablets $35.1 USD
    Save $179.10
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Do you need a prescription for trazodone?

Yes, trazodone is only available with a valid physician Rx.

How much is trazodone without Insurance in the US?

Our website gives two competitive savings options to US customers who wish to purchase trazodone, as either a brand or generic, if available. The first is access to medications through our mail-order online pharmacy. The second is by using the Now Patient Rx Advantage Card, which can be used in over 65,000 pharmacies nationwide, across America. If you are insured, then in most cases, the cash price will be significantly cheaper than the copay.

What will my out-of-pocket cost be for trazodone in the US?

There are no out-of-pocket (OOP) costs because we are currently only offering a cash-based option to purchase medications.

Is Now Patient a trazodone savings card?

Yes. Save up to 90% on your trazodone with the FREE Now Patient Rx Advantage card*.
*Based on the difference between the U&C submitted by the pharmacy and the price the patients pay.

Can you handle Rx transfers for home delivery in the US?

Yes. If you use the mail-order online pharmacy option, then we can handle requests by you to have your prescription transferred to our pharmacy for home delivery. We can even help you manage your refills by giving you timely reminders, so you do not run out of your medication.

Is Now Patient a trazodone coupon provider in the US?

No. Now Patient does not provide trazodone coupons or FREE trazodone samples.

Do you accept commercial, Medicare or Medicaid coverage for trazodone in the US?

No. Currently, we only offer cash-based options for purchase, therefore we do not require your insurance benefit details. In the future, our plan is to be able to handle commercial insurance, Medicare and Medicaid including cases where you have multiple health plans that provide benefit coverage (e.g. Medicaid and Commercial). We also anticipate being able to handle more complex scenarios such as using primary insurance combined with a manufacturer copay assistance program.

Does Now Patient work with Medicare?

Our cash-based prices for medications are typically cheaper than Medicare copays. We do not bill Medicare Part D (standalone drug coverage) or Medicare Advantage (combined health and drug coverage). When you purchase your medication from Now Patient, you will be doing so out of your pocket. The spend will not count towards your plan deductibles or gaps.

Does Now Patient work with Commercial Insurance?

Our cash-based prices for medications are typically cheaper than commercial plan copays. We do not bill your commercial plan. When you purchase your medication from Now Patient, you will be doing so out of your pocket. The spend will not count towards your plan deductibles or gaps.

What should you do if you use too much trazodone?


Call your doctor right away or seek immediate medical attention if your symptoms do not improve or they become worse after using trazodone. You can also call 800-222-1222 to reach the American Association of Poison Control Centers or use its online resource if you think you’ve used too much trazodone. But if you have severe symptoms, call 911 (or your local emergency number) immediately or go to the nearest emergency room.


If you think it is an emergency, call 999 or find your nearest A&E
If you need help now, but it’s not an emergency go to 111.nhs.uk or call 111. Alternatively you can speak to one of our pharmacists or use the Now Patient app to make an appointment with your GP.

What should I do if I miss my dose?

There are occasions when people forget to take their medication at correct prescribed times. This may not only have an effect on potentially making the medication less effective but it may also inadvertently lead to taking doses too close together, thereby increasing the risks of side effects.

Click here to find out what to do if you forgot to take your medication

What is generic trazodone?

Generic trazodone refers to the non-brand-name version of the medication. It contains the same active ingredient as the brand-name drug but is typically less expensive.

FDA approval of trazodone

Trazodone is approved by the U.S. Food and Drug Administration (FDA) for the treatment of major depressive disorder.

Active ingredient of trazodone

The active ingredient of trazodone is trazodone hydrochloride.

US brand name of trazodone and manufacturer

Trazodone is available in the US under various brand names, including Desyrel and Oleptro. The manufacturers may vary depending on the brand names.

UK brand name of trazodone and manufacturer

In the UK, trazodone is available under various brand names, including Molipaxin and trazodone. The manufacturer may vary depending on the brand name.

Prescription requirement for trazodone

A prescription (Rx) is required for trazodone in both the US and the UK.

Availability of trazodone in the UK with NHS prescription

Trazodone is available in the UK with an NHS prescription.

Conditions treated by trazodone

Trazodone is primarily used for the treatment of mental health disorders such as major depressive disorder. It may also be used off-label for other conditions, such as insomnia and anxiety.

How does trazodone work?

The exact mechanism of action of trazodone is not fully understood. It is believed to work by increasing the levels of serotonin, a neurotransmitter, in the brain, which helps to improve mood and alleviate depressive symptoms.

Forms of trazodone available

Trazodone is available in various forms, including immediate-release tablets and extended-release tablets.

Dosage of trazodone

The dosage of trazodone may vary depending on the specific condition being treated, the severity of the condition, and other individual factors. It is important to follow the recommended dosage instructions provided by the healthcare provider.

Directions for trazodone use

Use trazodone as directed by the healthcare provider. It is usually taken orally with or without food, depending on the specific formulation. It is important to take the medication regularly and at the same time each day.

Warnings and precautions for trazodone

  • Trazodone may cause drowsiness or dizziness. It is important to avoid activities that require mental alertness until the effects of the medication are known
  • Trazodone may increase the risk of suicidal thoughts or behavior, particularly in children, adolescents, and young adults. Close monitoring is necessary during treatment
  • Trazodone may interact with other medications and substances, including alcohol, and may require dosage adjustments or close monitoring when used concomitantly
  • Trazodone may cause a serious condition called serotonin syndrome/toxicity. There is an increased risk if you are taking other medicines that increase serotonin
  • Tell your doctor if you have ever had a heart attack, high blood pressure, bleeding problems, sickle cell anemia, Peyronie’s disease, glaucoma, heart disease, liver disease, or kidney impairment
  • Trazodone passes into breast milk. Speak to your doctor before breast-feeding

Possible side effects of trazodone

Common side effects of trazodone may include drowsiness, dry mouth, dizziness, lightheadedness, blurred vision, and constipation. If these side effects persist or worsen, it is important to contact a healthcare provider. Get medical help right away if you have a serious side effect such as an allergic reaction. Symptoms include hives, trouble breathing, worsening shortness of breath, sore throat, chest pain, swelling of the face, tongue or throat, red skin lesions, blisters, and serious skin reactions.

Interactions with other drugs

Trazodone may interact with certain medications, including antifungals such as ketoconazole, NSAIDs such as ibuprofen, carbamazepine, digoxin, phenytoin, sedatives, selective serotonin reuptake inhibitors (SSRIs) such as citalopram, fluoxetine, or paroxetine, monoamine oxidase inhibitors (MAOIs), such as isocarboxazid, linezolid, methylene blue, phenelzine, tranylcypromine, or selegiline, St. John’s wort, and tricyclic antidepressants such as amitriptyline. It is important to inform your healthcare provider about all the prescription drugs, over the counter nonprescription medications, herbal products, supplements, and vitamins you are taking to avoid potential adverse effects and drug interactions.

Similar drugs to trazodone

Other antidepressant medications, such as selective serotonin reuptake inhibitors (SSRIs) and serotonin-norepinephrine reuptake inhibitors (SNRIs), may be used as alternatives to trazodone for the treatment of major depressive disorder.


Stefano Mirabello Medical Reviewer
Pharmacist / B.Pharm
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