Key facts about Trabectedin
What dosages is Trabectedin available in?
Trabectedin is available as a 1 mg injection for IV use.
What is Trabectedin used for?
Trabectedin is an alkylating agent and is used for the following:
Liposarcoma that has spread or can’t be removed
Leiomyosarcoma that has spread or can’t be removed
How does Trabectedin work?
Trabectedin is an alkylating agent and works by slowing down the growth of cancer cells.
How do I take Trabectedin?
Trabectedin is typically dosed as 1.5 mg/m2 body surface area as a 24-hour intravenous infusion, every 3 weeks through a central venous line. Your dose may be lower if you have liver problems.
Is it safe for me to take Trabectedin?
Trabectedin is a safe and effective treatment when used for FDA licensed indications. However, like all medications, they may give you unwanted side effects. You should always discuss potential side effects with your physician to ensure the medication is suitable and right for you.
Trabectedin Common Side Effects
Common side effects of Trabectedin:
- Nausea
- Fatigue
- Vomiting
- Constipation
- Decreased appetite
- Diarrhea
- Peripheral edema
- Shortness of breath
- Headache
Trabectedin Serious Side Effects
Serious side effects are rare with Trabectedin. Contact your doctor if you experience any of the following.
- Severe muscle problems (rhabdomyolysis)
- Severe infections
- Liver or heart problems
- Leakage of Trabectedin out of your vein during the infusion
Effects of other drugs, drug classes and over-the-counter products on Trabectedin
The following medications may interact with Trabectedin:
- CYP3A inhibitors: Avoid concomitant strong CYP3A inhibitors
- • CYP3A inducers: Avoid concomitant strong CYP3A inducers
Who makes Trabectedin?
Various FDA-approved generic manufacturers
Is Trabectedin safe in pregnancy?
Based on its mechanism of action, Trabectedin can cause fetal harm when administered to a pregnant woman. If you can become pregnant, you should use effective contraception during therapy and for at least 2 months after the last dose of Trabectedin. Advise males with female partners of reproductive potential to use effective contraception during therapy and for at least 5 months after the last dose of Trabectedin.
