tolvaptan
Used for Chronic Kidney Disease
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Manufactured by various FDA-approved generic manufacturers.
*You can pay as little as $0 per fill using Drug Coupons or Patient Assistance Programs. Subject to applicability & eligibility requirements.
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tolvaptan Uses, Side Effects, Interactions, Warnings & Dosing
What dosages is tolvaptan available in?
tolvaptan is available as a 15 mg and 30 mg oral tablet.
What is tolvaptan used for?
tolvaptan is a vasopressin receptor antagonist and is used to treat:
- Low blood sodium levels with a high blood volume (hypervolemic hyponatremia)
- Low blood sodium levels with a normal blood volume (euvolemic hyponatremia)
How does tolvaptan work?
tolvaptan is a vasopressin receptor antagonist. It works by blocking a natural hormone in your body called vasopressin from attaching to the vasopressin-2 receptor in your kidneys. When this happens, your kidney doesn’t absorb as much water back into your body and you end up urinating the water out. This causes your blood sodium level to go up.
How do I take tolvaptan?
The typical starting dose is 15 mg by mouth once per day. Your provider might slowly raise the dose to up to 60 mg once per day, depending on how your blood sodium levels respond to the medication and if you’re having side effects. The maximum duration of treatment is 30 days.
Is it safe for me to take tolvaptan?
tolvaptan is a safe and effective treatment when used for FDA licensed indications. However, like all medications, they may give you unwanted side effects. You should always discuss potential side effects with your physician to ensure the medication is suitable and right for you. You should not use this medication if you have any of the following:
- Autosomal dominant polycystic kidney disease (ADPKD) outside of FDA-approved REMS
- Are unable to respond appropriately to thirst
- Hypovolemic hyponatremia
- Concomitant use of strong CYP3A inhibitors
- Anuria
tolvaptan Common Side Effects
Common side effects of tolvaptan:
- Feeling thirsty
- Dry mouth
- Urinating more often and more volume
- Lack of energy
- Constipation
- High blood sugar
tolvaptan Serious Side Effects
Serious side effects are rare with tolvaptan. Contact your healthcare provider immediately if you experience any of the following.
- Osmotic demyelination syndrome: confusion, problems swallowing, slurred speech, low energy, weakness in face, arms, or legs
- Liver problems or liver failure: yellowing of your skin or the whites of your eyes, confusion, fatigue, poor appetite, nausea, stomach discomfort, vomiting
Losing too much body fluid: dry mouth, dry skin, fast heart rate, dizziness, lightheadedness, feeling tired - High blood potassium levels: tiredness, muscle weakness, tingling or numbness, irregular heartbeat, trouble breathing
Effects of other drugs, drug classes and over-the-counter products on tolvaptan
The following medications may interact with tolvaptan: Avoid concomitant use with:
- Moderate CYP3A inhibitors
- Strong CYP3A inducers
- V2-receptor antagonists
Monitor serum potassium during concomitant therapy with:
- Angiotensin receptor blockers
- Angiotensin converting enzyme inhibitors
- Potassium sparing diuretics
Who makes tolvaptan?
Various FDA-approved generic manufacturers
Is tolvaptan safe in pregnancy?
tolvaptan may cause fetal harm. You should talk to your healthcare provider before taking this medication if you are pregnant.
What is the brand name for tolvaptan?
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Medical Disclaimer
NowPatient has taken all reasonable steps to ensure that all material is factually accurate, complete, and current. However, the knowledge and experience of a qualified healthcare professional should always be sought after instead of using the information on this page. Before taking any drug, you should always speak to your doctor or another qualified healthcare provider.
The information provided here about medications is subject to change and is not meant to include all uses, precautions, warnings, directions, drug interactions, allergic reactions, or negative effects. The absence of warnings or other information for a particular medication does not imply that the medication or medication combination is appropriate for all patients or for all possible purposes.
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