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MEDICAL INFORMATION
Tolvaptan Key Facts
What dosages is Tolvaptan available in?
Tolvaptan is available as a 15mg, 30mg, 45mg and 90mg tablet.
What is Tolvaptan used for?
Tolvaptan is a vasopressin V2 receptor antagonist that is used to slow the kidney function decline in adults who are at risk of rapidly progressing autosomal dominant polycystic kidney disease (ADPKD).
How does Tolvaptan work?
Tolvaptan works by targeting the hormone vasopressin which is elevated in people with autosomal dominant polycystic kidney disease (ADPKD). Vasopressin can cause cysts (fluid-filled sacs) to grow. Therefore by targetting this hormone, the progression of cysts is reduced and this slows kidney function decline.
How do I take Tolvaptan?
Tolvaptan is a taken orally, twice a day. The starting dose for Tolvaptan is 60 mg/day (splite between 45mg upon waking and 15mg after 8 hours). Your nephrologist may increase your dosage for optimal therapeutic dosing. Normally, the first dose is taken when you wake up, and the second dose is taken 8 hours later.
Is it safe for me to take Tolvaptan?
Tolvaptan is a safe and effective treatment when used for FDA licensed indications. However, Tolvaptan can cause serious liver problems that can lead to the need for a liver transplant or can lead to death. You should stop taking Tolvaptan and call your healthcare provider right away if you experience side effects of feeling tired or loss of appetite.
Tolvaptan Common Side Effects
Common side effects of Tolvaptan include:
- excessive thirst
- increased urination
Tolvaptan Serious Side Effects
Serious side effects are rare with Tolvaptan but if you notice any of the following, then it could be a sign of serious liver problems:
- feeling tired
- loss of appetite
- nausea
- right upper stomach (abdomen) pain or tenderness
- vomiting
- fever
- rash
- itching
- yellowing of the skin and white part of the eye (jaundice)
dark urine
Effects of other drugs, drug classes and over-the-counter products on Tolvaptan
The following medications may interact with Tolvaptan:
- ketoconazole
- grapefruit juice
- statins
- bosentan
- glyburide
- nateglinide
- repaglinide
- methotrexate
- furosemide
- desmopressin
Who makes Tolvaptan?
Various FDA-approved generic manufacturers
Is Tolvaptan safe in pregnancy?
Tolvaptan should be discontinued during pregnancy. It should also be avoided while women are breastfeeding.
Medical Disclaimer
NowPatient has taken all reasonable steps to ensure that all material is factually accurate, complete, and current. However, the knowledge and experience of a qualified healthcare professional should always be sought after instead of using the information on this page. Before taking any drug, you should always speak to your doctor or another qualified healthcare provider.
The information provided here about medications is subject to change and is not meant to include all uses, precautions, warnings, directions, drug interactions, allergic reactions, or negative effects. The absence of warnings or other information for a particular medication does not imply that the medication or medication combination is appropriate for all patients or for all possible purposes.
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