tolvaptan
Used for Chronic Kidney Disease
Are you tired of high medication costs? Our service offers unbeatable savings on your tolvaptan prescription medication. We provide a range of solutions to help you save up to 100% on your medication costs*. Whether you are insured, uninsured, underinsured, or simply looking to reduce your out-of-pocket expenses, we've got you covered.
Manufactured by various FDA-approved generic manufacturers.
*You can pay as little as $0 per fill using Drug Coupons or Patient Assistance Programs. Subject to applicability & eligibility requirements.
This content is intended for US audiences only
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tolvaptan key facts
What dosages is tolvaptan available in?
tolvaptan is available as a 15 mg and 30 mg oral tablet.
What is tolvaptan used for?
tolvaptan is a vasopressin receptor antagonist and is used to treat:
- Low blood sodium levels with a high blood volume (hypervolemic hyponatremia)
- Low blood sodium levels with a normal blood volume (euvolemic hyponatremia)
How does tolvaptan work?
tolvaptan is a vasopressin receptor antagonist. It works by blocking a natural hormone in your body called vasopressin from attaching to the vasopressin-2 receptor in your kidneys. When this happens, your kidney doesn’t absorb as much water back into your body and you end up urinating the water out. This causes your blood sodium level to go up.
How do I take tolvaptan?
The typical starting dose is 15 mg by mouth once per day. Your provider might slowly raise the dose to up to 60 mg once per day, depending on how your blood sodium levels respond to the medication and if you’re having side effects. The maximum duration of treatment is 30 days.
Is it safe for me to take tolvaptan?
tolvaptan is a safe and effective treatment when used for FDA licensed indications. However, like all medications, they may give you unwanted side effects. You should always discuss potential side effects with your physician to ensure the medication is suitable and right for you. You should not use this medication if you have any of the following:
- Autosomal dominant polycystic kidney disease (ADPKD) outside of FDA-approved REMS
- Are unable to respond appropriately to thirst
- Hypovolemic hyponatremia
- Concomitant use of strong CYP3A inhibitors
- Anuria
tolvaptan Common Side Effects
Common side effects of tolvaptan:
- Feeling thirsty
- Dry mouth
- Urinating more often and more volume
- Lack of energy
- Constipation
- High blood sugar
tolvaptan Serious Side Effects
Serious side effects are rare with tolvaptan. Contact your healthcare provider immediately if you experience any of the following.
- Osmotic demyelination syndrome: confusion, problems swallowing, slurred speech, low energy, weakness in face, arms, or legs
- Liver problems or liver failure: yellowing of your skin or the whites of your eyes, confusion, fatigue, poor appetite, nausea, stomach discomfort, vomiting
Losing too much body fluid: dry mouth, dry skin, fast heart rate, dizziness, lightheadedness, feeling tired - High blood potassium levels: tiredness, muscle weakness, tingling or numbness, irregular heartbeat, trouble breathing
Effects of other drugs, drug classes and over-the-counter products on tolvaptan
The following medications may interact with tolvaptan: Avoid concomitant use with:
- Moderate CYP3A inhibitors
- Strong CYP3A inducers
- V2-receptor antagonists
Monitor serum potassium during concomitant therapy with:
- Angiotensin receptor blockers
- Angiotensin converting enzyme inhibitors
- Potassium sparing diuretics
Who makes tolvaptan?
Various FDA-approved generic manufacturers
Is tolvaptan safe in pregnancy?
tolvaptan may cause fetal harm. You should talk to your healthcare provider before taking this medication if you are pregnant.
The FDA's medical product safety reporting program for health professionals, patients and consumers.
Learn more about reporting side effectsDrug Savings Guide
A practical guide to saving money and receiving support with prescription costs
How can NowPatient help me to lower the cost of my tolvaptan prescription?
After you create a FREE account with NowPatient, you will have access to 4 programs that can help lower the cost of your tolvaptan prescription
Applicability to each program will be dependent on your insurance status.
How do the NowPatient tolvaptan savings programs work?
After you have created your FREE account with NowPatient, you can access the various programs from your account dashboard. Each program has clear instructions on how to check your eligibility. You can see how the process works by clicking on the feature link below and seeing the ‘How it works’ steps.
Drug Coupon and Patient Assistance Programs require an eligibility quiz to be completed.
Are the NowPatient tolvaptan savings programs suitable for everyone, regardless of insurance status?
No. Each program has its own eligibility and applicability requirements. The table below shows if a program is available to you, based on your insurance status.
| Rx Advantage Card* for tolvaptan | Canadian Prescription Savings* for tolvaptan | tolvaptan Drug Coupon* | tolvaptan Patient Assistance Program* | |
| Insured (federal, state or government) | Available | Available | Not Available | Available If Offered by Pharmaceutical Company |
| Insured (Commercial or Private) | Available | Available | Available If Offered by Pharmaceutical Company | Available If Offered by Pharmaceutical Company |
| Uninsured | Available | Available | Not Available | Available If Offered by Pharmaceutical Company |
| Insured but without pharmacy benefit or drug coverage | Available | Available | Not Available | Available If Offered by Pharmaceutical Company |
*This is not insurance.
Are the NowPatient drug savings programs suitable for brand and generic versions of tolvaptan?
No. Each program has applicability requirements. Please see below
| Rx Advantage Card* for tolvaptan | Canadian Prescription Savings* for tolvaptan | tolvaptan Drug Coupon* | tolvaptan Patient Assistance Program* | |
| Brand | Yes | Yes | Yes, If Offered by Pharmaceutical Company | Yes, If Offered by Pharmaceutical Company |
| Generic | Yes | Yes | No | No |
*This is not insurance.
If you have Medicare Part D or Medicare Advantage and none of the tolvaptan savings options are applicable or affordable for me, what can you do?
If you are insured with Medicare and the tolvaptan drug savings options are not applicable to you and still remain unaffordable, then you can check Medicaid eligibility in your state by following the instructions at HealthCare.gov.
The government site is easy to use and after you have selected your state, it will navigate you to the appropriate contact point to make the application. State Medicaid programs may cover the full cost of your medication.
People who qualify for both Medicare and Medicaid are called ‘dual eligibles’.
If you are denied Medicaid for tolvaptan, and you are still unable to afford your copay or co-insurance element (for example if you are in the coverage gap or Donut Hole) then you may be eligible for a federal support program like Low Income Subsidy. To be eligible for Low Income Subsidy, you need to be a resident in one of the 50 States or the District of Columbia. You can check eligibility online at SSA Medicare D Extra Help. You can also call Social Security at 1-800-772-1213 (TTY 1-800-325-0778).
I am uninsured or underinsured and none of the tolvaptan prescription saving options are applicable or affordable for me, what can I do?
If you are uninsured or underinsured (for example, tolvaptan is not covered by your plan) and the drug savings options are not applicable or still unaffordable, then you can check Medicaid eligibility in your state by following the instructions at HealthCare.gov.
The government site is easy to use and you can select your state and it will navigate you to the appropriate contact point to make the application. State Medicaid programs may cover the full cost of your medication.
If you are denied and all else fails, and if you have been prescribed tolvaptan for an FDA-approved indication, you can call the pharmaceutical company to see if they have any other assistance programs.
I am commercially or privately insured and none of the tolvaptan prescription saving options are applicable or affordable for me, what can I do?
If your medication is not covered by your plan, you can appeal your insurance company’s decision. Sometimes, a formal appeal can result in the drug being covered if it is deemed medically necessary.
If you cannot afford your copay contribution, then you can check Medicaid eligibility in your state by following the instructions at HealthCare.gov.
However, being privately insured might complicate your eligibility for Medicaid, as having private insurance may be considered in the financial eligibility assessment.
The government site is easy to use and you can select your state and it will navigate you to the appropriate contact point to make the application. If you qualify, state Medicaid may cover the full cost of your medication.
If I have federal, state or commercial insurance and none of the tolvaptan prescription saving options are applicable or affordable for me, are there any other support organisations that can help me with my co-insurance or copay contributions?
If you have already tried Medicaid and received a denial letter or if you are insured with Medicare and have been denied Low-Income Subsidy, then you can try one of the following organizational support programs:
1. Patient Access Network Foundation (PAN) assistance for tolvaptan
If you are having trouble paying for your tolvaptan medication due to unaffordable copays or deductibles, the Patient Access Network Foundation (PAN), may be able to assist you. To qualify for PAN assistance for tolvaptan you will need to meet one or all of the following criteria:
- Your income is below 400% of the federal poverty level
- tolvaptan is prescribed for an approved FDA indication
- You live in and receive treatment in the United States or U.S. territories, even if you do not have U.S. citizenship
- You have Medicare insurance coverage that covers tolvaptan
- If tolvaptan is listed on PAN’s list of covered medications
You can check the Patient Access Network Foundation Website for more information.
2. HealthWell Foundation Copay Program for tolvaptan
If you are having trouble paying for your tolvaptan medication due to unaffordable copays or deductibles, the HealthWell Foundation Copay Program may be able to assist you. To qualify for assistance for tolvaptan you will need to meet the following criteria:
- You live in and are being treated in the United States
- You are insured and your plan covers tolvaptan
- If tolvaptan is listed on the HealthWell Foundation’s list of covered medications
You can check the HealthWell Foundation Website for more information.
3. Patient Advocate Foundation Co-Pay Relief Program for tolvaptan
Patient Advocate Foundation’s Co-Pay Relief program exists to help reduce the financial distress you or your family may face when paying for your tolvaptan treatment. If you qualify and can demonstrate the need, the foundation will provide you with direct payment covering co-pays, co-insurance, and deductibles. To qualify for assistance for tolvaptan you will need to meet the following criteria:
- You must be currently insured and have coverage for tolvaptan
- You must have a confirmed diagnosis and treatment plan
- You must reside and receive treatment in the United States
- Your Income must fall at or below 300% or 400% of the Federal Poverty Guideline (FPG) with consideration for the Cost of Living Index (COLI) and number in the household
- Applications can also be completed by contacting the program sponsor, toll-free at 866-512-3861.
You can check the Patient Advocate Foundation Website for more information.
Medical Disclaimer
NowPatient has taken all reasonable steps to ensure that all material is factually accurate, complete, and current. However, the knowledge and experience of a qualified healthcare professional should always be sought after instead of using the information on this page. Before taking any drug, you should always speak to your doctor or another qualified healthcare provider.
The information provided here about medications is subject to change and is not meant to include all uses, precautions, warnings, directions, drug interactions, allergic reactions, or negative effects. The absence of warnings or other information for a particular medication does not imply that the medication or medication combination is appropriate for all patients or for all possible purposes.
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