TolvaptanPrices, Coupons & Savings

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*Based on the difference between the U&C price submitted and the price the patient paid, as of April 2023.

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  2. Tolvaptan
    Generic for Samsca
    25 tablets $1555.5 USD
    Save $5977.75
  3. Tolvaptan
    Generic for Samsca
    30 tablets $1900.5 USD
    Save $7139.40
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Do you need a prescription for tolvaptan?

Yes, tolvaptan is only available with a valid physician Rx.

How much is tolvaptan without Insurance in the US?

Our website gives two competitive savings options to US customers who wish to purchase tolvaptan, as either a brand or generic, if available. The first is access to medications through our mail-order online pharmacy. The second is by using the Now Patient Rx Advantage Card, which can be used in over 65,000 pharmacies nationwide, across America. If you are insured, then in most cases, the cash price will be significantly cheaper than the copay.

What will my out-of-pocket cost be for tolvaptan in the US?

There are no out-of-pocket (OOP) costs because we are currently only offering a cash-based option to purchase medications.

Is Now Patient a tolvaptan savings card?

Yes. Save up to 90% on your tolvaptan with the FREE Now Patient Rx Advantage card*.
*Based on the difference between the U&C submitted by the pharmacy and the price the patients pay.

Can you handle Rx transfers for home delivery in the US?

Yes. If you use the mail-order online pharmacy option, then we can handle requests by you to have your prescription transferred to our pharmacy for home delivery. We can even help you manage your refills by giving you timely reminders, so you do not run out of your medication.

Is Now Patient a tolvaptan coupon provider in the US?

No. Now Patient does not provide tolvaptan coupons or FREE tolvaptan samples.

Do you accept commercial, Medicare or Medicaid coverage for tolvaptan in the US?

No. Currently, we only offer cash-based options for purchase, therefore we do not require your insurance benefit details. In the future, our plan is to be able to handle commercial insurance, Medicare and Medicaid including cases where you have multiple health plans that provide benefit coverage (e.g. Medicaid and Commercial). We also anticipate being able to handle more complex scenarios such as using primary insurance combined with a manufacturer copay assistance program.

Does Now Patient work with Medicare?

Our cash-based prices for medications are typically cheaper than Medicare copays. We do not bill Medicare Part D (standalone drug coverage) or Medicare Advantage (combined health and drug coverage). When you purchase your medication from Now Patient, you will be doing so out of your pocket. The spend will not count towards your plan deductibles or gaps.

Does Now Patient work with Commercial Insurance?

Our cash-based prices for medications are typically cheaper than commercial plan copays. We do not bill your commercial plan. When you purchase your medication from Now Patient, you will be doing so out of your pocket. The spend will not count towards your plan deductibles or gaps.

What should you do if you use too much tolvaptan?


Call your doctor right away or seek immediate medical attention if your symptoms do not improve or they become worse after using tolvaptan. You can also call 800-222-1222 to reach the American Association of Poison Control Centers or use its online resource if you think you’ve used too much tolvaptan. But if you have severe symptoms, call 911 (or your local emergency number) immediately or go to the nearest emergency room.


If you think it is an emergency, call 999 or find your nearest A&E
If you need help now, but it’s not an emergency go to 111.nhs.uk or call 111. Alternatively you can speak to one of our pharmacists or use the Now Patient app to make an appointment with your GP.

What should I do if I miss my dose?

There are occasions when people forget to take their medication at correct prescribed times. This may not only have an effect on potentially making the medication less effective but it may also inadvertently lead to taking doses too close together, thereby increasing the risks of side effects.

Click here to find out what to do if you forgot to take your medication

What is generic tolvaptan?

Generic tolvaptan refers to the non-brand-name version of the medication. It contains the same active ingredient as the brand-name drug but is typically less expensive.

FDA approval of tolvaptan

Tolvaptan is approved by the U.S. Food and Drug Administration (FDA) for the treatment of hyponatremia associated with various conditions, including syndrome of inappropriate antidiuretic hormone secretion (SIADH) and heart failure.

Active ingredient of tolvaptan

The active ingredient of tolvaptan is tolvaptan.

US brand name of tolvaptan and manufacturer

Tolvaptan is available in the US under the brand names Jynarque and Samsca. It is manufactured by Otsuka Pharmaceutical Co., Ltd.

UK brand name of tolvaptan and manufacturer

In the UK, tolvaptan is available under the brand name Jinarc. The manufacturer may vary depending on the brand name.

Prescription requirement for tolvaptan

A prescription (Rx) is required for tolvaptan in both the US and the UK.

Availability of tolvaptan in the UK with NHS prescription

Tolvaptan is available in the UK with an NHS prescription.

Conditions treated by tolvaptan

Tolvaptan is used for the treatment of hyponatremia, which is a condition characterized by low serum sodium levels in the blood. It is specifically indicated for the treatment of hyponatremia associated with syndrome of inappropriate antidiuretic hormone (SIADH), cirrhosis, and heart failure. It is also used to slow kidney function decline in adult patients at risk of autosomal dominant polycystic kidney disease (ADPKD).

How does tolvaptan work?

Tolvaptan is a selective vasopressin V2 receptor antagonist. It works by blocking the action of vasopressin, a hormone that regulates water balance in the body. By blocking the vasopressin receptors, tolvaptan helps to increase urine output and remove excess water from the body, thereby correcting hyponatremia.

Forms of tolvaptan available

Tolvaptan is available in the form of oral tablets.

Dosage of tolvaptan

The dosage of tolvaptan may vary depending on the specific condition being treated and individual patient factors. It is important to follow the recommended dosage instructions and medication guide provided by a healthcare professional.

Directions for tolvaptan use

Tolvaptan should be taken exactly as directed by the healthcare provider. The tablets are usually taken orally, with or without food. It is important to swallow the tablets whole and not crush, chew, or break them.

Warnings and contraindications for tolvaptan

  • Tolvaptan may have certain risks and potential side effects. It is important to discuss these with a healthcare provider before starting the medication
  • It is important to monitor electrolyte levels, particularly sodium, while taking tolvaptan. Rapid correction of hyponatremia can have adverse effects, and the dosage should be carefully adjusted
  • Tolvaptan should not be used for ADPKD outside of the FDA-approved REMS, because of the risk of hepatotoxicity (liver injury)
  • Tolvaptan may cause osmotic demyelination syndrome (serious nerve damage caused by rapid increases in blood sodium levels)
  • Tell your doctor if you have liver disease, very low levels of sodium in your blood, have malnutrition, or drink large amounts of alcohol, before starting treatment
  • Avoid grapefruit or grapefruit juice while taking this medication
  • It is not known if tolvaptan passes into breast milk. Speak to your doctor before breast-feeding

Use of tolvaptan if pregnant or planning pregnancy

The use of tolvaptan during pregnancy is not recommended, as it may harm the unborn baby. It should be avoided in women who are planning to become pregnant.

Possible side effects of tolvaptan

In clinical trials common side effects of tolvaptan may include thirst, dry mouth, constipation, increased urination, and weakness. Serious side effects such as liver failure (pain in the upper stomach, dark urine, loss of appetite, yellowing of the eyes or skin) are possible, but less common. Promptly report any concerning symptoms to a healthcare provider. Get medical help right away if you have a serious side effect such as an allergic reaction. Symptoms include hives, trouble breathing, worsening shortness of breath, sore throat, chest pain, swelling of the face, tongue or throat, red skin lesions, blisters, and serious skin reactions.

Interactions with other drugs

Tolvaptan may interact with certain medications, including certain antifungals such as ketoconazole, desmopressin, angiotensin-converting enzyme inhibitors, diuretics, or potassium supplements. It is important to inform your healthcare provider about all the prescription drugs, over the counter nonprescription medications, herbal products, supplements, and vitamins you are taking to avoid potential adverse effects and drug interactions.

Similar drugs to tolvaptan

Other medications used for the treatment of hyponatremia include conivaptan and demeclocycline.


Stefano Mirabello Medical Reviewer
Pharmacist / B.Pharm
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