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Tenecteplase is available as a 50 mg single-dose vial for reconstitution.

Tenecteplase is used for the treatment of a severe heart attack in people who aren’t receiving percutaneous coronary intervention (PCI) (a procedure that opens up clogged blood vessels in the heart). Additionally, the American Heart Association (AHA) and American Stroke Association (ASA) suggest that Tenecteplase can be used for the treatment of stroke caused by a blood clot in blood vessels in the brain (ischemic stroke). For stroke, Tenecteplase can be used for people who aren’t going to have a thrombectomy, which is a procedure where a healthcare provider removes a blood clot from a blood vessel.

Tenecteplase is known as a thrombolytic. It behaves just like a protein in your body called tissue plasminogen activator (tPA), which helps break up blood clots. This helps to restore bloodflow in your blood vessels.

Tenecteplase is for intravenous administration only, administered as a single bolus over 5 seconds. Individualize dosage based on patient’s weight.

Tenecteplase is a safe and effective treatment when used for FDA licensed indications. However, like all medications, they may give you unwanted side effects. You should always discuss potential side effects with your physician to ensure the medication is suitable and right for you. You should not use this medication if you have any of the following.

• Active internal bleeding
• History of cerebrovascular accident
• Intracranial or intraspinal surgery or trauma within 2 months
• Intracranial neoplasm, arteriovenous malformation, or aneurysm
• Known bleeding diathesis
• Severe uncontrolled hypertension

• Common side effects of Tenecteplase:
• Bleeding
• Hypersensitivity

Serious side effects are rare with Tenecteplase. Contact your healthcare provider immediately if you experience any of the following.

• Bleeding: Tenecteplase can cause bleeding, including intracranial hemorrhage and fatal bleeding. Concomitant use of other drugs that impair hemostasis increases the risk of bleeding
  Thromboembolism: The use of thrombolytics can increase the risk of thrombo-embolic events in patients with high likelihood of left heart thrombus, such as patients with mitral stenosis or atrial fibrillation
  Increased Risk of Heart Failure and Recurrent Ischemia when used with Planned Percutaneous Coronary Intervention (PCI) in STEMI
• Hypersensitivity: Hypersensitivity, including urticarial / anaphylactic reactions, have been reported after administration of Tenecteplase (e.g., anaphylaxis, angioedema, laryngeal edema, rash, and urticaria)

• There are no major drug interactions listed for Tenecteplase. However, always let your physician and pharmacist know about any other medications or supplements (including prescribed and over-the-counter medications, vitamins, and dietary or herbal supplements) that you are currently taking

Various FDA-approved generic manufacturers

It is not known if Tenecteplase will harm your unborn baby. Tell your healthcare provider if you are pregnant or plan to become pregnant while using Tenecteplase.

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