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Manufactured by various FDA-approved generic manufacturers.

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tenecteplase Uses, Side Effects, Interactions, Warnings & Dosing

What dosages is tenecteplase available in?

What dosages is tenecteplase available in?

tenecteplase is available as a 50 mg single-dose vial for reconstitution.

What is tenecteplase used for?

What is tenecteplase used for?

tenecteplase is used for the treatment of a severe heart attack in people who aren’t receiving percutaneous coronary intervention (PCI) (a procedure that opens up clogged blood vessels in the heart). Additionally, the American Heart Association (AHA) and American Stroke Association (ASA) suggest that tenecteplase (tenecteplase) can be used for the treatment of stroke caused by a blood clot in blood vessels in the brain (ischemic stroke). For stroke, tenecteplase (tenecteplase) can be used for people who aren’t going to have a thrombectomy, which is a procedure where a healthcare provider removes a blood clot from a blood vessel.

How does tenecteplase work?

How does tenecteplase work?

tenecteplase is known as a thrombolytic. It behaves just like a protein in your body called tissue plasminogen activator (tPA), which helps break up blood clots. This helps to restore bloodflow in your blood vessels.

How do I take tenecteplase?

How do I take tenecteplase?

tenecteplase is for intravenous administration only, administered as a single bolus over 5 seconds. Individualize dosage based on patient’s weight.

Is it safe for me to take tenecteplase?

Is it safe for me to take tenecteplase?

tenecteplase is a safe and effective treatment when used for FDA licensed indications. However, like all medications, they may give you unwanted side effects. You should always discuss potential side effects with your physician to ensure the medication is suitable and right for you. You should not use this medication if you have any of the following.

  • Active internal bleeding
  • History of cerebrovascular accident
  • Intracranial or intraspinal surgery or trauma within 2 months
  • Intracranial neoplasm, arteriovenous malformation, or aneurysm
  • Known bleeding diathesis
  • Severe uncontrolled hypertension
tenecteplase Common Side Effects

tenecteplase Common Side Effects

  • Common side effects of tenecteplase:
  • Bleeding
  • Hypersensitivity
tenecteplase Serious Side Effects

tenecteplase Serious Side Effects

Serious side effects are rare with tenecteplase. Contact your healthcare provider immediately if you experience any of the following.

  • Bleeding: tenecteplase can cause bleeding, including intracranial hemorrhage and fatal bleeding. Concomitant use of other drugs that impair hemostasis increases the risk of bleeding
    Thromboembolism: The use of thrombolytics can increase the risk of thrombo-embolic events in patients with high likelihood of left heart thrombus, such as patients with mitral stenosis or atrial fibrillation
    Increased Risk of Heart Failure and Recurrent Ischemia when used with Planned Percutaneous Coronary Intervention (PCI) in STEMI
  • Hypersensitivity: Hypersensitivity, including urticarial / anaphylactic reactions, have been reported after administration of tenecteplase (e.g., anaphylaxis, angioedema, laryngeal edema, rash, and urticaria)
Effects of other drugs, drug classes and over-the-counter products on tenecteplase

Effects of other drugs, drug classes and over-the-counter products on tenecteplase

  • There are no major drug interactions listed for tenecteplase. However, always let your physician and pharmacist know about any other medications or supplements (including prescribed and over-the-counter medications, vitamins, and dietary or herbal supplements) that you are currently taking
Who makes tenecteplase?

Who makes tenecteplase?

Various FDA-approved generic manufacturers

Is tenecteplase safe in pregnancy?

Is tenecteplase safe in pregnancy?

It is not known if tenecteplase will harm your unborn baby. Tell your healthcare provider if you are pregnant or plan to become pregnant while using tenecteplase.


What to do if you missed your tenecteplase dose

The FDA's medical product safety reporting program for health professionals, patients and consumers.

Learn more about reporting side effects
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NowPatient has taken all reasonable steps to ensure that all material is factually accurate, complete, and current. However, the knowledge and experience of a qualified healthcare professional should always be sought after instead of using the information on this page. Before taking any drug, you should always speak to your doctor or another qualified healthcare provider.

The information provided here about medications is subject to change and is not meant to include all uses, precautions, warnings, directions, drug interactions, allergic reactions, or negative effects. The absence of warnings or other information for a particular medication does not imply that the medication or medication combination is appropriate for all patients or for all possible purposes.

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