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Spevigo is the brand name for spesolimab-sbzo and is available as an injection for IV use.

Spevigo is available as a 450 mg/7.5 mL (60 mg/mL) solution for IV use.

Spevigo is a monoclonal antibody and is used for treatment of generalized pustular psoriasis flares.

Spevigo is a monoclonal antibody. It works by blocking the interleukin-36 receptor (IL-36R), which is normally a key part of your immune system’s signaling pathway. Blocking this pathway can help manage GPP flares caused by IL-36 (inflammatory proteins).

Spevigo is typically dosed as 900 mg injected as a single dose into your veins over 90 minutes. If your GPP flare symptoms don’t go away, your provider might give you an additional 900 mg dose (over 90 minutes) one week after the first dose.

Spevigo is a safe and effective treatment when used for FDA licensed indications. However, like all medications, they may give you unwanted side effects. You should always discuss potential side effects with your physician to ensure the medication is suitable and right for you.

Common side effects of Spevigo:

• Weakness and feeling tired
• Nausea and vomiting
• Headache
• Itchy skin
• Bruising around the infusion site
• Urinary tract infection

Serious side effects are rare with Spevigo. Contact your healthcare provider immediately if you experience any of the following.

• Serious allergic reaction: trouble breathing; fever; hives; blisters; swelling of the lips, throat, tongue, or face

There are no major drug interactions listed for Spevigo. However, always let your physician and pharmacist know about any other medications or supplements (including prescribed and over-the-counter medications, vitamins, and dietary or herbal supplements) that you are currently taking.

Boehringer Ingelheim Pharmaceuticals, Inc.

It is not known if Spevigo may harm your unborn baby. It should be used during pregnancy only if the potential benefit justifies the potential risk to the fetus.

• Spesolimab-SBZO