sertraline
Used for Anxiety and Depression
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Manufactured by various FDA-approved generic manufacturers.
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sertraline Uses, Side Effects, Interactions, Warnings & Dosing
What dosages is sertraline available in?
sertraline is available as a 25 mg, 50 mg, and 100 mg oral tablet and a 20 mg/ml oral solution.
What is sertraline used for?
sertraline is a SSRI and is used for the following:
- Major depressive disorder (MDD)
- Obsessive-compulsive disorder (OCD)
- Panic disorder (PD)
- Post-traumatic stress disorder (PTSD)
- Premenstrual dysphoric disorder (PMDD)
- Social anxiety disorder (SAD)
How does sertraline work?
sertraline is a selective serotonin reuptake inhibitor (SSRI). It works by raising the levels of serotonin, an important chemical in your brain that’s involved with regulating your mood and anxiety.
How do I take sertraline?
sertraline is dosed as follows:
Adults
- Depression, PD, OCD, PTSD, SAD: The typical starting dose ranges from 25 mg to 50 mg by mouth daily. The typical maintenance dose ranges from 50 mg to 200 mg daily, depending on your condition
- PMDD: The typical starting dose is 50 mg by mouth daily. Your psychiatrist might ask you to take this medication daily throughout your menstrual cycle (up to 150 mg daily), or to only take it daily starting 2 weeks before your period begins and stopping when your period ends (up to 100 mg daily)
Children (age 6 years and older)
- OCD: The typical starting dose ranges from 25 mg to 50 mg by mouth daily, depending on your child’s age. The typical maintenance dose ranges from 50 mg to 200 mg daily
Your physician will determine your dose based on your age and medical condition. Your dose might be different if you have liver problems.
Is it safe for me to take sertraline?
sertraline is a safe and effective treatment when used for FDA licensed indications. However, like all medications, they may give you unwanted side effects. You should always discuss potential side effects with your physician to ensure the medication is suitable and right for you. You should not use this medication any of the following apply to you:
- Currently take or have taken a monoamine oxidase inhibitor (MAOI), linezolid (Zyvox), or methylene blue (ProvayBlue) in the last 14 days
- Taking pimozide
- Taking disulfiram (sertraline liquid only)
sertraline Common Side Effects
Common side effects of sertraline:
- Nausea
- Diarrhea
- Difficulty sleeping
- Dry mouth
- Sleepiness
sertraline Serious Side Effects
Serious side effects are rare with sertraline. Contact your healthcare provider immediately if you experience any of the following.
- Suicidal thoughts or behaviors
- Serotonin syndrome: fast heart rate, dizziness, sweating, flushing, tremor (shakiness), muscle stiffness, muscle twitching or spasms, uncoordinated movement, distress, seizures, distress, hallucinations, coma
- Abnormal heart rhythm (QT prolongation): chest pounding, short of breath, chest pain, feeling faint or lightheaded
- Severe bleeding: bruising that doesn’t improve, black-colored stools, pink or red-colored urine, coughing up or vomiting blood, or unusual bleeding from the nose or gums
- Low blood sodium levels: nausea, fatigue, headache, confusion, disoriented, hallucinations (seeing things that aren’t real), seizures, unconsciousness
Effects of other drugs, drug classes and over-the-counter products on sertraline
The following medications may interact with sertraline:
- Protein-bound drugs: Monitor for adverse reactions and reduce dosage of sertraline or other protein-bound drugs (e.g., warfarin) as warranted
- CYP2D6 substrates: Reduce dosage of drugs metabolized by CYP2D6
Who makes sertraline?
Various FDA-approved generic manufacturers
Is sertraline safe in pregnancy?
sertraline use in the third trimester may increase risk for persistent pulmonary hypertension and withdrawal in the neonate. You and your doctor will have to decide if you should take sertraline while you are pregnant or if you plan to become pregnant. There is a pregnancy exposure registry that monitors pregnancy outcomes in women exposed to antidepressants during pregnancy. Healthcare providers should encourage patients to enroll by calling the National Pregnancy Registry for Antidepressants at 1-866-961-2388 or visiting online at women’s health
What to do if you missed your sertraline dose
The FDA's medical product safety reporting program for health professionals, patients and consumers.
Learn more about reporting side effectsDrug Savings Tips
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Medical Disclaimer
NowPatient has taken all reasonable steps to ensure that all material is factually accurate, complete, and current. However, the knowledge and experience of a qualified healthcare professional should always be sought after instead of using the information on this page. Before taking any drug, you should always speak to your doctor or another qualified healthcare provider.
The information provided here about medications is subject to change and is not meant to include all uses, precautions, warnings, directions, drug interactions, allergic reactions, or negative effects. The absence of warnings or other information for a particular medication does not imply that the medication or medication combination is appropriate for all patients or for all possible purposes.
Things to know
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