SertralinePrices, Coupons & Savings

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*Based on the difference between the U&C price submitted and the price the patient paid, as of April 2023.

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  2. Sertraline
    Generic for Zoloft
    30 tablets $3.9 USD
    Save $18.60
  3. Sertraline
    Generic for Zoloft
    30 tablets $3.9 USD
    Save $18.60
  4. Sertraline
    Generic for Zoloft
    30 tablets $4.2 USD
    Save $18.30
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Save up to 90% of your branded or generic medications using the Now Patient Rx Advantage Card

Do you need a prescription for sertraline?

Yes, sertraline is only available with a valid physician Rx.

How much is sertraline without Insurance in the US?

Our website gives two competitive savings options to US customers who wish to purchase sertraline, as either a brand or generic, if available. The first is access to medications through our mail-order online pharmacy. The second is by using the Now Patient Rx Advantage Card, which can be used in over 65,000 pharmacies nationwide, across America. If you are insured, then in most cases, the cash price will be significantly cheaper than the copay.

What will my out-of-pocket cost be for sertraline in the US?

There are no out-of-pocket (OOP) costs because we are currently only offering a cash-based option to purchase medications.

Is Now Patient a sertraline savings card?

Yes. Save up to 90% on your sertraline with the FREE Now Patient Rx Advantage card*.
*Based on the difference between the U&C submitted by the pharmacy and the price the patients pay.

Can you handle Rx transfers for home delivery in the US?

Yes. If you use the mail-order online pharmacy option, then we can handle requests by you to have your prescription transferred to our pharmacy for home delivery. We can even help you manage your refills by giving you timely reminders, so you do not run out of your medication.

Is Now Patient a sertraline coupon provider in the US?

No. Now Patient does not provide sertraline coupons or FREE sertraline samples.

Do you accept commercial, Medicare or Medicaid coverage for sertraline in the US?

No. Currently, we only offer cash-based options for purchase, therefore we do not require your insurance benefit details. In the future, our plan is to be able to handle commercial insurance, Medicare and Medicaid including cases where you have multiple health plans that provide benefit coverage (e.g. Medicaid and Commercial). We also anticipate being able to handle more complex scenarios such as using primary insurance combined with a manufacturer copay assistance program.

Does Now Patient work with Medicare?

Our cash-based prices for medications are typically cheaper than Medicare copays. We do not bill Medicare Part D (standalone drug coverage) or Medicare Advantage (combined health and drug coverage). When you purchase your medication from Now Patient, you will be doing so out of your pocket. The spend will not count towards your plan deductibles or gaps.

Does Now Patient work with Commercial Insurance?

Our cash-based prices for medications are typically cheaper than commercial plan copays. We do not bill your commercial plan. When you purchase your medication from Now Patient, you will be doing so out of your pocket. The spend will not count towards your plan deductibles or gaps.

What should you do if you use too much sertraline?


Call your doctor right away or seek immediate medical attention if your symptoms do not improve or they become worse after using sertraline. You can also call 800-222-1222 to reach the American Association of Poison Control Centers or use its online resource if you think you’ve used too much sertraline. But if you have severe symptoms, call 911 (or your local emergency number) immediately or go to the nearest emergency room.


If you think it is an emergency, call 999 or find your nearest A&E
If you need help now, but it’s not an emergency go to 111.nhs.uk or call 111. Alternatively you can speak to one of our pharmacists or use the Now Patient app to make an appointment with your GP.

What should I do if I miss my dose?

There are occasions when people forget to take their medication at correct prescribed times. This may not only have an effect on potentially making the medication less effective but it may also inadvertently lead to taking doses too close together, thereby increasing the risks of side effects.

Click here to find out what to do if you forgot to take your medication

What is generic Sertraline?

Generic sertraline refers to the non-brand-name version of the medication. It contains the same active ingredient as the brand-name drug but is typically less expensive.

FDA approval of sertraline

Sertraline is approved by the U.S. Food and Drug Administration (FDA) for the treatment of various mental health conditions, including major depressive disorder, obsessive-compulsive disorder (OCD), panic disorder, post-traumatic stress disorder (PTSD), and social anxiety disorder.

Active ingredient of sertraline

The active ingredient of sertraline is sertraline hydrochloride.

US brand name of sertraline and manufacturer

Sertraline is available in the US under the brand name Zoloft. It is manufactured by Pfizer Inc.

UK brand name of sertraline and manufacturer

In the UK, sertraline is available under various brand names, including Lustral. The manufacturer may vary depending on the brand name.

Prescription requirement for sertraline

A prescription (Rx) is required for sertraline in both the US and the UK.

Availability of sertraline in the UK with NHS prescription

Sertraline is available in the UK with an NHS prescription.

Conditions treated by sertraline

Sertraline is an antidepressant medication, primarily used for the treatment of major depressive disorder, OCD, panic disorder, PTSD, premenstrual dysphoric disorder, and social anxiety disorder. It may also be used off-label for other conditions, as determined by the healthcare provider.

How does sertraline work?

Sertraline belongs to a class of medications called selective serotonin reuptake inhibitors (SSRIs). It works by increasing the levels of serotonin, a neurotransmitter, in the brain. By balancing the levels of serotonin, sertraline helps improve mood, reduce anxiety, and alleviate symptoms associated with various mental health conditions.

Forms of sertraline available

Sertraline is available in the form of oral tablets and oral concentrate solution.

Dosage of sertraline

The dose of sertraline may vary depending on the specific condition being treated, the patient’s age and weight, and other individual factors. It is important to follow the prescribed dosage instructions provided by the healthcare provider.

Directions for sertraline use

Sertraline should be taken exactly as directed by the healthcare provider. The medication is usually taken once daily, with or without food. It is important to swallow the tablets whole and not crush or chew them. The oral concentrate solution should be diluted before use.

Warnings and precautions for sertraline

  • Sertraline should be used with caution in individuals with certain medical conditions, such as liver or kidney problems. Dose adjustments may be necessary
  • It may interact with certain medications, including monoamine oxidase inhibitors (MAOIs) such as isocarboxazid, linezolid, methylene blue, phenelzine, selegiline, or tranylcypromine
  • Sertraline may rarely cause a serious condition called serotonin syndrome/toxicity. The risk is increased if you are taking other medication that increases your serotonin levels
  • Suddenly stopping sertraline may cause withdrawal symptoms. Speak to your doctor if you are considering discontinuing this medication
  • Tell your doctor if you have a family history of bipolar disorder or manic-depressive disorder, liver disease, seizures, thyroid problems, or a family history of glaucoma

Use of sertraline during pregnancy

The use of sertraline during pregnancy should be carefully considered, and the potential risks and benefits should be discussed with a healthcare provider.

Use of sertraline while breastfeeding

Sertraline is excreted in breast milk but is generally considered safe to use while breastfeeding. It is recommended to consult a healthcare professional before using sertraline while breastfeeding.

Possible side effects of sertraline

Common side effects of sertraline may include nausea, diarrhea, insomnia, drowsiness, dry mouth, and sexual dysfunction. Serious side effects are rare but can occur. Tell the doctor immediately if you notice worsening depression, have suicidal thoughts, worsening anxiety, panic attacks, irritability, or trouble sleeping.

Interactions with other drugs

Ropinirole may interact with certain medications, including anticoagulants such as warfarin, nonsteroidal anti-inflammatory drugs (NSAIDs) such as ibuprofen and naproxen, pimozide, sedatives, other selective serotonin-reuptake inhibitors such as citalopram, fluoxetine (Prozac), or fluvoxamine, serotonin–norepinephrine reuptake inhibitors (SNRI) such as duloxetine and venlafaxine, and tricyclic antidepressants. It is important to inform your healthcare provider about all the prescription drugs, over the counter nonprescription medication, supplements, and vitamins you are taking to avoid potential adverse effects and drug interactions.

Similar drugs to sertraline

Other SSRIs used for the treatment of mental health conditions include fluoxetine, escitalopram, and paroxetine.


About Now Patient

Now Patient’s online services are available in the US and UK. We help you manage your prescriptions, doctor appointments, test results, health risks, and a lot more, all in one place for FREE. If you are in the United States, you could enjoy savings using Now Patient’s mail-order pharmacy or use the Now Patient Rx Advantage Card at over 65,000 pharmacies, with savings of up to 90% on popular FDA-approved brand and generic medications like Ozempic, Mounjaro, clopidogrel and lots more. We do not currently handle commercial insurance, Medicare or Medicaid. UK NHS and private prescriptions are delivered FREE of charge across England & Wales by our UK NHS online pharmacy.

Stefano Mirabello Medical Reviewer
Pharmacist / B.Pharm
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