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RYBREVANT

RYBREVANT

Used for Cancer

View RYBREVANT savings options available to you including Manufacturer Coupons, Rx Advantage Savings Card, Canadian Prescription Savings or RYBREVANT Patient Assistance Program.

Programs are suitable for individuals who want to buy RYBREVANT without insurance, with insurance or for those who are underinsured. You can pay as little as $0 per fill.*

Manufactured by Janssen Pharmaceuticals

*Applicable to Drug Coupons & Patient Assistance Programs

This content is intended for US audiences only

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    Save up to 90%

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    Patient Assistance Programs

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Jamie Winn NowPatientGreen tick
Updated on 26 Apr 2024

Learn more about RYBREVANT

What is RYBREVANT?

What is RYBREVANT?

RYBREVANT is the brand name for amivantamab-vmjw and is available as an injection for IV use.

What dosages is RYBREVANT available in?

What dosages is RYBREVANT available in?

RYBREVANT is available as a 350 mg/7 mL (50 mg/mL) solution that is an injection for IV use.

What is RYBREVANT used for?

What is RYBREVANT used for?

RYBREVANT is an EGFR and MET inhibitor that is used to treat:

  • Locally advanced or metastatic non-small cell lung cancer (NSCLC) with EGFR exon 20 insertion mutations in people who have previously received platinum-based chemotherapy
How does RYBREVANT work?

How does RYBREVANT work?

RYBREVANT is an EGFR and MET inhibitor. It’s a bispecific monoclonal antibody that targets proteins on tumor cells called EGFR and MET. MET and EGFR are proteins in the body involved in signaling cells to grow and divide.

In certain lung cancers, mutations (changes) in specific genes lead to abnormal MET and EGFR proteins. This causes cells to grow out of control. RYBREVANT works by attaching (binding) to EGFR and MET proteins, blocking the tumor from growing, and alerting the immune system to destroy those abnormal cells.

How do I take RYBREVANT?

How do I take RYBREVANT?

RYBREVANT is given as an intravenous (IV) infusion. The typical dose of RYBREVANT depends on your weight:

  • Weight less than 80 kg (176 lbs): The recommended dose is 1050 mg
  • Weight 80 kg (176 lbs) or more: The recommended dose is 1400 mg
  • The dosing schedule for RYBREVANT is in 28-day cycles
  • During your first cycle, you’ll receive an infusion on days 1 and 2, then weekly on day 8, day 15, and day 22.
  • After your first cycle, you’ll get the infusion every other week (day 1 and day 15 of each cycle)
Is it safe for me to take RYBREVANT?

Is it safe for me to take RYBREVANT?

RYBREVANT is a safe and effective treatment when used for FDA licensed indications. However, like all medications, they may give you unwanted side effects. You should always discuss potential side effects with your physician to ensure the medication is suitable and right for you.

RYBREVANT Common Side Effects

RYBREVANT Common Side Effects

Common side effects of RYBREVANT:

  • Rash
  • Infusion reaction (e.g., trouble breathing, chills, nausea)
  • Nail infection
  • Muscle, bone, or joint pain
  • Shortness of breath
  • Nausea
  • Fatigue
  • Swelling
  • Mouth sores
  • Cough
  • Constipation
  • Vomiting
RYBREVANT Serious Side Effects

RYBREVANT Serious Side Effects

Serious side effects are rare with RYBREVANT. Contact your healthcare provider immediately if you experience any of the following.

  • Infusion reactions: hives, breathing problems, dizziness, chills, chest pain, swelling of the mouth or lips
  • Lung damage: cough, shortness of breath, fever
  • Severe skin reactions: burning, redness, rashes, blisters, or peeling
  • Eye problems: eye pain, redness, dryness, or itching; vision changes
Effects of other drugs, drug classes and over-the-counter products on RYBREVANT

Effects of other drugs, drug classes and over-the-counter products on RYBREVANT

  • There are no major drug interactions listed for RYBREVANT. However, always let your physician and pharmacist know about any other medications or supplements (including prescribed and over-the-counter medications, vitamins, and dietary or herbal supplements) that you are currently taking
Who makes RYBREVANT?

Who makes RYBREVANT?

Janssen Pharmaceuticals

Is RYBREVANT safe in pregnancy?

Is RYBREVANT safe in pregnancy?

Based on its mechanism of action and findings from animal models, RYBREVANT can cause fetal harm when administered to a pregnant woman. If you can become pregnant, you should to use effective contraception during treatment and for 3 months after the last dose of RYBREVANT.

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What to do if you missed your RYBREVANT dose

The FDA's medical product safety reporting program for health professionals, patients and consumers.

Learn more about reporting side effects
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Medical Disclaimer

NowPatient has taken all reasonable steps to ensure that all material is factually accurate, complete, and current. However, the knowledge and experience of a qualified healthcare professional should always be sought after instead of using the information on this page. Before taking any drug, you should always speak to your doctor or another qualified healthcare provider.

The information provided here about medications is subject to change and is not meant to include all uses, precautions, warnings, directions, drug interactions, allergic reactions, or negative effects. The absence of warnings or other information for a particular medication does not imply that the medication or medication combination is appropriate for all patients or for all possible purposes.

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