RYBREVANT
Used for Cancer
Are you tired of high medication costs? Our service offers unbeatable savings on your RYBREVANT prescription medication. We provide a range of solutions to help you save up to 100% on your medication costs*. Whether you are insured, uninsured, underinsured, or simply looking to reduce your out-of-pocket expenses, we've got you covered.
Manufactured by Janssen Pharmaceuticals
*You can pay as little as $0 per fill using Drug Coupons or Patient Assistance Programs. Subject to applicability & eligibility requirements.
This content is intended for US audiences only
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RYBREVANT key facts
What is RYBREVANT?
RYBREVANT is the brand name for amivantamab-vmjw and is available as an injection for IV use.
What dosages is RYBREVANT available in?
RYBREVANT is available as a 350 mg/7 mL (50 mg/mL) solution that is an injection for IV use.
What is RYBREVANT used for?
RYBREVANT is an EGFR and MET inhibitor that is used to treat:
- Locally advanced or metastatic non-small cell lung cancer (NSCLC) with EGFR exon 20 insertion mutations in people who have previously received platinum-based chemotherapy
How does RYBREVANT work?
RYBREVANT is an EGFR and MET inhibitor. It’s a bispecific monoclonal antibody that targets proteins on tumor cells called EGFR and MET. MET and EGFR are proteins in the body involved in signaling cells to grow and divide.
In certain lung cancers, mutations (changes) in specific genes lead to abnormal MET and EGFR proteins. This causes cells to grow out of control. RYBREVANT works by attaching (binding) to EGFR and MET proteins, blocking the tumor from growing, and alerting the immune system to destroy those abnormal cells.
How do I take RYBREVANT?
RYBREVANT is given as an intravenous (IV) infusion. The typical dose of RYBREVANT depends on your weight:
- Weight less than 80 kg (176 lbs): The recommended dose is 1050 mg
- Weight 80 kg (176 lbs) or more: The recommended dose is 1400 mg
- The dosing schedule for RYBREVANT is in 28-day cycles
- During your first cycle, you’ll receive an infusion on days 1 and 2, then weekly on day 8, day 15, and day 22.
- After your first cycle, you’ll get the infusion every other week (day 1 and day 15 of each cycle)
Is it safe for me to take RYBREVANT?
RYBREVANT is a safe and effective treatment when used for FDA licensed indications. However, like all medications, they may give you unwanted side effects. You should always discuss potential side effects with your physician to ensure the medication is suitable and right for you.
RYBREVANT Common Side Effects
Common side effects of RYBREVANT:
- Rash
- Infusion reaction (e.g., trouble breathing, chills, nausea)
- Nail infection
- Muscle, bone, or joint pain
- Shortness of breath
- Nausea
- Fatigue
- Swelling
- Mouth sores
- Cough
- Constipation
- Vomiting
RYBREVANT Serious Side Effects
Serious side effects are rare with RYBREVANT. Contact your healthcare provider immediately if you experience any of the following.
- Infusion reactions: hives, breathing problems, dizziness, chills, chest pain, swelling of the mouth or lips
- Lung damage: cough, shortness of breath, fever
- Severe skin reactions: burning, redness, rashes, blisters, or peeling
- Eye problems: eye pain, redness, dryness, or itching; vision changes
Effects of other drugs, drug classes and over-the-counter products on RYBREVANT
- There are no major drug interactions listed for RYBREVANT. However, always let your physician and pharmacist know about any other medications or supplements (including prescribed and over-the-counter medications, vitamins, and dietary or herbal supplements) that you are currently taking
Who makes RYBREVANT?
Janssen Pharmaceuticals
Is RYBREVANT safe in pregnancy?
Based on its mechanism of action and findings from animal models, RYBREVANT can cause fetal harm when administered to a pregnant woman. If you can become pregnant, you should to use effective contraception during treatment and for 3 months after the last dose of RYBREVANT.
The FDA's medical product safety reporting program for health professionals, patients and consumers.
Learn more about reporting side effectsDrug Savings Guide
A practical guide to saving money and receiving support with prescription costs
How can NowPatient help me to lower the cost of my RYBREVANT prescription?
After you create a FREE account with NowPatient, you will have access to 4 programs that can help lower the cost of your RYBREVANT prescription
Applicability to each program will be dependent on your insurance status.
How do the NowPatient RYBREVANT savings programs work?
After you have created your FREE account with NowPatient, you can access the various programs from your account dashboard. Each program has clear instructions on how to check your eligibility. You can see how the process works by clicking on the feature link below and seeing the ‘How it works’ steps.
Drug Coupon and Patient Assistance Programs require an eligibility quiz to be completed.
Are the NowPatient RYBREVANT savings programs suitable for everyone, regardless of insurance status?
No. Each program has its own eligibility and applicability requirements. The table below shows if a program is available to you, based on your insurance status.
| Rx Advantage Card* for RYBREVANT | Canadian Prescription Savings* for RYBREVANT | RYBREVANT Drug Coupon* | RYBREVANT Patient Assistance Program* | |
| Insured (federal, state or government) | Available | Available | Not Available | Available If Offered by Pharmaceutical Company |
| Insured (Commercial or Private) | Available | Available | Available If Offered by Pharmaceutical Company | Available If Offered by Pharmaceutical Company |
| Uninsured | Available | Available | Not Available | Available If Offered by Pharmaceutical Company |
| Insured but without pharmacy benefit or drug coverage | Available | Available | Not Available | Available If Offered by Pharmaceutical Company |
*This is not insurance.
Are the NowPatient drug savings programs suitable for brand and generic versions of RYBREVANT?
No. Each program has applicability requirements. Please see below
| Rx Advantage Card* for RYBREVANT | Canadian Prescription Savings* for RYBREVANT | RYBREVANT Drug Coupon* | RYBREVANT Patient Assistance Program* | |
| Brand | Yes | Yes | Yes, If Offered by Pharmaceutical Company | Yes, If Offered by Pharmaceutical Company |
| Generic | Yes | Yes | No | No |
*This is not insurance.
If you have Medicare Part D or Medicare Advantage and none of the RYBREVANT savings options are applicable or affordable for me, what can you do?
If you are insured with Medicare and the RYBREVANT drug savings options are not applicable to you and still remain unaffordable, then you can check Medicaid eligibility in your state by following the instructions at HealthCare.gov.
The government site is easy to use and after you have selected your state, it will navigate you to the appropriate contact point to make the application. State Medicaid programs may cover the full cost of your medication.
People who qualify for both Medicare and Medicaid are called ‘dual eligibles’.
If you are denied Medicaid for RYBREVANT, and you are still unable to afford your copay or co-insurance element (for example if you are in the coverage gap or Donut Hole) then you may be eligible for a federal support program like Low Income Subsidy. To be eligible for Low Income Subsidy, you need to be a resident in one of the 50 States or the District of Columbia. You can check eligibility online at SSA Medicare D Extra Help. You can also call Social Security at 1-800-772-1213 (TTY 1-800-325-0778).
I am uninsured or underinsured and none of the RYBREVANT prescription saving options are applicable or affordable for me, what can I do?
If you are uninsured or underinsured (for example, RYBREVANT is not covered by your plan) and the drug savings options are not applicable or still unaffordable, then you can check Medicaid eligibility in your state by following the instructions at HealthCare.gov.
The government site is easy to use and you can select your state and it will navigate you to the appropriate contact point to make the application. State Medicaid programs may cover the full cost of your medication.
If you are denied and all else fails, and if you have been prescribed RYBREVANT for an FDA-approved indication, you can call the pharmaceutical company to see if they have any other assistance programs.
I am commercially or privately insured and none of the RYBREVANT prescription saving options are applicable or affordable for me, what can I do?
If your medication is not covered by your plan, you can you can appeal your insurance company’s decision. Sometimes, a formal appeal can result in the drug being covered if it is deemed medically necessary.
If you cannot afford your copay, then you can check Medicaid eligibility in your state by following the instructions at HealthCare.gov.
However, being privately insured might complicate your eligibility for Medicaid, as having private insurance may be considered in the financial eligibility assessment.
The government site is easy to use and you can select your state and it will navigate you to the appropriate contact point to make the application. If you qualify, state Medicaid may cover the full cost of your medication.
If I have federal, state or commercial insurance and none of the RYBREVANT prescription saving options are applicable or affordable for me, are there any other support organisations that can help me with my co-insurance or copay?
If you have already tried Medicaid and received a denial letter or if you are insured with Medicare and have been denied Low-Income Subsidy, then you can try one of the following organizational support programs:
1. Patient Access Network Foundation (PAN) assistance for RYBREVANT
If you are having trouble paying for your RYBREVANT medication due to unaffordable copays or deductibles, the Patient Access Network Foundation (PAN), may be able to assist you. To qualify for PAN assistance for RYBREVANT you will need to meet one or all of the following criteria:
- Your income is below 400% of the federal poverty level
- RYBREVANT is prescribed for an approved FDA indication
- You live in and receive treatment in the United States or U.S. territories, even if you do not have U.S. citizenship
- You have Medicare insurance coverage that covers RYBREVANT
- If RYBREVANT is listed on PAN’s list of covered medications
You can check the Patient Access Network Foundation Website for more information.
2. HealthWell Foundation Copay Program for RYBREVANT
If you are having trouble paying for your RYBREVANT medication due to unaffordable copays or deductibles, the HealthWell Foundation Copay Program may be able to assist you. To qualify for assistance for RYBREVANT you will need to meet the following criteria:
- You live in and are being treated in the United States
- You are insured and your plan covers RYBREVANT
- If RYBREVANT is listed on the HealthWell Foundation’s list of covered medications
You can check the HealthWell Foundation Website for more information.
3. Patient Advocate Foundation Co-Pay Relief Program for RYBREVANT
Patient Advocate Foundation’s Co-Pay Relief program exists to help reduce the financial distress you or your family may face when paying for your RYBREVANT treatment. If you qualify and can demonstrate the need, the foundation will provide you with direct payment covering co-pays, co-insurance, and deductibles. To qualify for assistance for RYBREVANT you will need to meet the following criteria:
- You must be currently insured and have coverage for RYBREVANT
- You must have a confirmed diagnosis and treatment plan
- You must reside and receive treatment in the United States
- Your Income must fall at or below 300% or 400% of the Federal Poverty Guideline (FPG) with consideration for the Cost of Living Index (COLI) and number in the household
- Applications can also be completed by contacting the program sponsor, toll-free at 866-512-3861.
You can check the Patient Advocate Foundation Website for more information.
Medical Disclaimer
NowPatient has taken all reasonable steps to ensure that all material is factually accurate, complete, and current. However, the knowledge and experience of a qualified healthcare professional should always be sought after instead of using the information on this page. Before taking any drug, you should always speak to your doctor or another qualified healthcare provider.
The information provided here about medications is subject to change and is not meant to include all uses, precautions, warnings, directions, drug interactions, allergic reactions, or negative effects. The absence of warnings or other information for a particular medication does not imply that the medication or medication combination is appropriate for all patients or for all possible purposes.
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