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Romosozumab-AQQG is available as a 105 mg/1.17 mL solution in a single-use prefilled syringe.

Romosozumab-AQQG is a sclerostin inhibitor that is used to treat bone loss (osteoporosis) in women after menopause:

• With high risk for fracture
• Who can’t take other medications for bone loss
• Who tried other medications for bone loss that didn’t work

Romosozumab-AQQG is a sclerostin inhibitor, which means it blocks sclerostin from working. Sclerostin is a protein in your body that normally stops bone growth and promotes bone decay. So by blocking sclerostin, this medication helps your bones grow and prevents bone breakdown at the same time.

This medication needs to be given by your healthcare provider. The typical dose is two injections (210 mg total) under the skin once a month for 12 months.

Romosozumab-AQQG is a safe and effective treatment when used for FDA licensed indications. However, like all medications, they may give you unwanted side effects. You should always discuss potential side effects with your physician to ensure the medication is suitable and right for you. You should not use this medication if you have low calcium levels (hypocalcemia).

Common side effects of Romosozumab-AQQG:

• Joint pain
• Headache

Serious side effects are rare with Romosozumab-AQQG. Contact your healthcare provider immediately if you experience any of the following.

• Heart attack: chest pain; shortness of breath; feeling dizzy
• Stroke: headache; vision changes; loss of balance; trouble talking; weakness or numbness in the arms, legs, or face, especially if happening on only one side of the body
• Allergic reaction: hives; rash; swelling of the face, lips, mouth, or tongue; difficulty breathing or swallowing
• Fractures in the thigh: dull or aching pain in the thigh, hip, or groin

The following medications may interact with Romosozumab-AQQG:

Various FDA-approved generic manufacturers

Romosozumab-AQQG is not indicated for use in women who can become pregnant.

• Evenity