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Rifampin is available as a 150 mg and 300 mg oral capsule.

Rifampin is a rifamycin antibiotic that is used to treat:z
Tuberculosis (TB) Meningococcal carriers (when there’s bacteria living in the nose and/or throat, but not causing infection)

Rifampin is a rifamycin antibiotic. It blocks an enzyme (protein) the bacteria need to eventually make proteins, so the bacteria can’t grow and spread.

The dose of Rifampin will be based on your age and weight. It is typically 5 mg/kg to 10 mg/kg (up to 600 mg per dose),once a day.

Rifampin is a safe and effective treatment when used for FDA licensed indications. However, like all medications, they may give you unwanted side effects. You should always discuss potential side effects with your physician to ensure the medication is suitable and right for you. You should not use this medication if you have a history of hypersensitivity to Rifampin or any of the components, or to any of the rifamycins.

Rifampin is contraindicated in patients who are also receiving ritonavir-boosted saquinavir due to an increased risk of severe hepatocellular toxicity. Rifampin is contraindicated in patients who are also receiving atazanavir, darunavir,
fosamprenavir, saquinavir, or tipranavir due to the potential of Rifampin to substantially decrease plasma concentrations of these antiviral drugs, which may result in loss of antiviral efficacy and/or development of viral resistance. Rifampin is contraindicated in patients receiving praziquantel since therapeutically effective blood levels of praziquantel may not be achieved. In patients receiving Rifampin who need immediate treatment with praziquantel alternative agents should be considered. However, if treatment with praziquantel is necessary, Rifampin should be discontinued
weeks before administration of praziquantel. Treatment with Rifampin can then be restarted one day after completion of praziquantel treatment. Rifampin is contraindicated in patients receiving lurasidone. Concomitant use of lurasidone
with strong CYP3A4 inducers (e.g., Rifampin) decreased the exposure of lurasidone compared to the use of lurasidone alone.

Common side effects of Rifampin:

• Temporary change in color (orange/yellow) of body fluids and teeth
• Upset stomach
• Diarrhea
• Headache
• Fever
• Nervous system problems affecting energy, movement, thinking, or behavior
• Nerve pain or numbness

Serious side effects are rare with Rifampin. Contact your healthcare provider immediately if you experience any of the following.

• Allergic reaction: fever, rash, swelling of your lips or tongue, trouble breathing
• Serious bleeds: bruising easily, blood in the urine or stool, bleeding that’s difficult to stop
• Liver problems: loss of appetite, nausea or vomiting, dark urine, or yellowing of the eyes or skin

The following medications may interact with Rifampin:

• Antiretrovirals: Concomitant use is contraindicated.
• Drug metabolizing enzymes and transporters affected by Rifampin include cytochromes
• P450 (CYP) 1A2, 2B6, 2C8, 2C9, 2C19, and 3A4, UDP-glucuronyltransferases (UGT)
• sulfotransferases, carboxylesterases, and transporters including P-glycoprotein (P-gp) and multidrug resistance-associated protein 2 (MRP2). Most drugs are substrates for one or more of these enzyme or transporter pathways and these pathways may be induced by Rifampin simultaneously. Therefore, Rifampin may increase the metabolism and decrease the activity of certain coadministered drugs or increase the activity of a coadministered pro-drug (where metabolic activation is required), and has the potential to perpetuate clinically important drug-drug interactions against many drugs and across many drug classes

Various FDA-approved generic manufacturers

Based on animal data, Rifampin may cause fetal harm. You should talk to your healthcare provider before taking this medication if you are pregnant. Rifampin should be used during pregnancy only if the potential benefit justifies the potential risk to the fetus.

• Rifadin