RIFADIN
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Manufactured by Sanofi
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RIFADIN Uses, Side Effects, Interactions, Warnings & Dosing
What is RIFADIN?
RIFADIN is the brand name for rifampin and is available as an oral capsule.
What dosages is RIFADIN available in?
RIFADIN is available as a 150 mg and 300 mg oral capsule.
What is RIFADIN used for?
RIFADIN is a rifamycin antibiotic that is used to treat:z
Tuberculosis (TB) Meningococcal carriers (when there’s bacteria living in the nose and/or throat, but not causing infection)
How does RIFADIN work?
RIFADIN is a rifamycin antibiotic. It blocks an enzyme (protein) the bacteria need to eventually make proteins, so the bacteria can’t grow and spread.
How do I take RIFADIN?
The dose of RIFADIN will be based on your age and weight. It is typically 5 mg/kg to 10 mg/kg (up to 600 mg per dose),once a day.
Is it safe for me to take RIFADIN?
RIFADIN is a safe and effective treatment when used for FDA licensed indications. However, like all medications, they may give you unwanted side effects. You should always discuss potential side effects with your physician to ensure the medication is suitable and right for you. You should not use this medication if you have a history of hypersensitivity to rifampin or any of the components, or to any of the rifamycins.
RIFADIN is contraindicated in patients who are also receiving ritonavir-boosted saquinavir due to an increased risk of severe hepatocellular toxicity. RIFADIN is contraindicated in patients who are also receiving atazanavir, darunavir,
fosamprenavir, saquinavir, or tipranavir due to the potential of rifampin to substantially decrease plasma concentrations of these antiviral drugs, which may result in loss of antiviral efficacy and/or development of viral resistance. RIFADIN is contraindicated in patients receiving praziquantel since therapeutically effective blood levels of praziquantel may not be achieved. In patients receiving RIFADIN who need immediate treatment with praziquantel alternative agents should be considered. However, if treatment with praziquantel is necessary, RIFADIN should be discontinued
weeks before administration of praziquantel. Treatment with RIFADIN can then be restarted one day after completion of praziquantel treatment. RIFADIN is contraindicated in patients receiving lurasidone. Concomitant use of lurasidone
with strong CYP3A4 inducers (e.g., rifampin) decreased the exposure of lurasidone compared to the use of lurasidone alone.
RIFADIN Common Side Effects
Common side effects of RIFADIN:
- Temporary change in color (orange/yellow) of body fluids and teeth
- Upset stomach
- Diarrhea
- Headache
- Fever
- Nervous system problems affecting energy, movement, thinking, or behavior
- Nerve pain or numbness
RIFADIN Serious Side Effects
Serious side effects are rare with RIFADIN. Contact your healthcare provider immediately if you experience any of the following.
- Allergic reaction: fever, rash, swelling of your lips or tongue, trouble breathing
- Serious bleeds: bruising easily, blood in the urine or stool, bleeding that’s difficult to stop
- Liver problems: loss of appetite, nausea or vomiting, dark urine, or yellowing of the eyes or skin
Effects of other drugs, drug classes and over-the-counter products on RIFADIN
The following medications may interact with RIFADIN:
- Antiretrovirals: Concomitant use is contraindicated.
- Drug metabolizing enzymes and transporters affected by rifampin include cytochromes
- P450 (CYP) 1A2, 2B6, 2C8, 2C9, 2C19, and 3A4, UDP-glucuronyltransferases (UGT)
- sulfotransferases, carboxylesterases, and transporters including P-glycoprotein (P-gp) and multidrug resistance-associated protein 2 (MRP2). Most drugs are substrates for one or more of these enzyme or transporter pathways and these pathways may be induced by rifampin simultaneously. Therefore, rifampin may increase the metabolism and decrease the activity of certain coadministered drugs or increase the activity of a coadministered pro-drug (where metabolic activation is required), and has the potential to perpetuate clinically important drug-drug interactions against many drugs and across many drug classes
Who makes RIFADIN?
Sanofi
Is RIFADIN safe in pregnancy?
Based on animal data, RIFADIN may cause fetal harm. You should talk to your healthcare provider before taking this medication if you are pregnant. RIFADIN should be used during pregnancy only if the potential benefit justifies the potential risk to the fetus.
The FDA's medical product safety reporting program for health professionals, patients and consumers.
Learn more about reporting side effects
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Medical Disclaimer
NowPatient has taken all reasonable steps to ensure that all material is factually accurate, complete, and current. However, the knowledge and experience of a qualified healthcare professional should always be sought after instead of using the information on this page. Before taking any drug, you should always speak to your doctor or another qualified healthcare provider.
The information provided here about medications is subject to change and is not meant to include all uses, precautions, warnings, directions, drug interactions, allergic reactions, or negative effects. The absence of warnings or other information for a particular medication does not imply that the medication or medication combination is appropriate for all patients or for all possible purposes.
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