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Renvela is the brand name for sevelamer carbonate and is available as an oral tablet and a powder for oral suspension.

Renvela is available as an 800 mg oral tablet and a 0.8 g and 2.4 g packets.

Renvela is a phosphate binder that is used to treat high blood phosphate levels in people ages 6 years and older with chronic kidney disease (CKD) on dialysis.

Renvela is a phosphate binder. It attaches to the phosphate (a nutrient) in your stomach that comes from food. This prevents phosphate from getting absorbed into the body and instead allows phosphate to leave the body. This lowers your blood phosphate levels to help protect your kidneys and bones.

Renvela is typically given at dose ranges from 800 mg to 2,400 mg by mouth three times daily with meals. Your provider will adjust your dose based on whether you were previously taking a phosphate binder, your blood phosphate levels, and body size (for children).

Renvela is a safe and effective treatment when used for FDA licensed indications. However, like all medications, they may give you unwanted side effects. You should always discuss potential side effects with your physician to ensure the medication is suitable and right for you. You should not use this medication if you have a bowel obstruction.

Common side effects of Renvela:

• Vomiting
• Nausea
• Diarrhea
• Indigestion
• Stomach pain
• Feeling gassy
• Constipation

Serious side effects are rare with Renvela. Contact your healthcare provider immediately if you experience any of the following.

• Stomach or intestine problems: bowel blockage, bleeding ulcers, severe stomach pain, blood in your stool

The following medications may interact with Renvela:

• For oral medication where a reduction in the bioavailability of that medication would have a clinically significant effect on its safety or efficacy, consider separation of the timing of administration and/or monitor clinical responses or blood levels of the concomitant medication
• Sevelamer did not alter the pharmacokinetics of digoxin, enalapril, iron metoprolol and warfarin
• Sevelamer has demonstrated interaction with ciprofloxacin, mycophenolate mofetil, and therefore, these drugs should be dosed separately from Renvela

Genzyme Corporation

Renvela is not absorbed systemically following oral administration and maternal use is not expected to result in fetal exposure to the drug. You should talk to your healthcare provider before taking this medication if you are pregnant.

• Sevelamer Carbonate