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Navin Khosla NowPatientGreen tick
Updated on 24 Apr 2024

ramelteon Uses, Side Effects, Interactions, Warnings & Dosing

What dosages is ramelteon available in?

What dosages is ramelteon available in?

ramelteon is available as an 8 mg oral tablet.

What is ramelteon used for?

What is ramelteon used for?

ramelteon is a melatonin receptor agonist and is used to treat insomnia.

How does ramelteon work?

How does ramelteon work?

ramelteon is a melatonin receptor agonist which means that it acts like melatonin. Melatonin is a natural hormone that your body makes when it is dark to help maintain a normal sleeping cycle. By working like melatonin, ramelteon helps you fall asleep faster.

How do I take ramelteon?

How do I take ramelteon?

ramelteon is dosed as 8 mg by mouth within 30 minutes before bedtime. Take it on an empty stomach. Don’t take more than 8 mg of ramelteon a day.

Is it safe for me to take ramelteon?

Is it safe for me to take ramelteon?

ramelteon is a safe and effective treatment when used for FDA licensed indications. However, like all medications, they may give you unwanted side effects. You should always discuss potential side effects with your physician to ensure the medication is suitable and right for you. You should not use this medication if you any of the following apply:

  • History of angioedema while taking ramelteon
  • Are taking fluvoxamine (strong CYP1A2 inhibitor):
  • Increases AUC for ramelteon and should not be used in combination
ramelteon Common Side Effects

ramelteon Common Side Effects

Common side effects of ramelteon:

  • Dizziness
  • Sleepiness
  • Fatigue
  • Nausea
  • Worsening insomnia
ramelteon Serious Side Effects

ramelteon Serious Side Effects

Serious side effects are rare with ramelteon. Contact your healthcare provider immediately if you experience any of the following.

  • Angioedema: swelling of your face, lips, tongue, or throat
    Suicidal thoughts or behaviors
Effects of other drugs, drug classes and over-the-counter products on ramelteon

Effects of other drugs, drug classes and over-the-counter products on ramelteon

The following medications may interact with ramelteon:

  • Rifampin (strong CYP enzyme inducer): Decreases exposure to and effects of ramelteon
  • Ketoconazole (strong CYP3A4 inhibitor): Increases AUC for ramelteon; administer with caution
  • Fluconazole (strong CYP2C9 inhibitor): Increases systemic exposure of ramelteon; administer with caution
  • Donepezil: Increases systemic exposure of ramelteon; patients should be closely monitored when ramelteon is coadministered with donepezil
  • Doxepin: Increases systemic exposure of ramelteon; patients should be closely monitored when ramelteon is coadministered with doxepin
  • Alcohol: Causes additive psychomotor impairment; should not be used in combination
Who makes ramelteon?

Who makes ramelteon?

Various FDA-approved generic manufacturers

Is ramelteon safe in pregnancy?

Is ramelteon safe in pregnancy?

It is not known if ramelteon can harm an unborn baby. It should be used during pregnancy only if the potential benefit justifies the potential risk to the fetus


What to do if you missed your ramelteon dose

The FDA's medical product safety reporting program for health professionals, patients and consumers.

Learn more about reporting side effects
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Medical Disclaimer

NowPatient has taken all reasonable steps to ensure that all material is factually accurate, complete, and current. However, the knowledge and experience of a qualified healthcare professional should always be sought after instead of using the information on this page. Before taking any drug, you should always speak to your doctor or another qualified healthcare provider.

The information provided here about medications is subject to change and is not meant to include all uses, precautions, warnings, directions, drug interactions, allergic reactions, or negative effects. The absence of warnings or other information for a particular medication does not imply that the medication or medication combination is appropriate for all patients or for all possible purposes.

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