PRIMAXIN I.V.
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Manufactured by Merck & Co., Inc.
*You can pay as little as $0 per fill using Drug Coupons or Patient Assistance Programs. Subject to applicability & eligibility requirements.
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PRIMAXIN I.V. Uses, Side Effects, Interactions, Warnings & Dosing
What is PRIMAXIN I.V.?
PRIMAXIN I.V. is the brand name for imipenem and cilastatin and is available as an injection for IV use.
What dosages is PRIMAXIN I.V. available in?
PRIMAXIN I.V. is available as an IV injection that contains 500 mg imipenem (anhydrous equivalent) and 500 mg cilastatin (free acid equivalent).
What is PRIMAXIN I.V. used for?
PRIMAXIN I.V. is a combination of imipenem, a penem antibacterial, and cilastatin, a renal dehydropeptidase inhibitor, indicated for the treatment of the following serious infections caused by designated susceptible bacteria:
- Lower respiratory tract infections
- Urinary tract infections
- Intra-abdominal infections
- Gynecologic infections
- Bacterial septicemia
- Bone and joint infections
- Skin and skin structure infections
- Endocarditis
How does PRIMAXIN I.V. work?
PRIMAXIN I.V. is a combination of imipenem, a penem
antibacterial, and cilastatin, a renal dehydropeptidase inhibitor. It works similar to the other beta-lactam antibiotics, which is to inactivate the penicillin-binding proteins (PBP) and cause cell wall lysis, or interfere with cell wall formation.
How do I take PRIMAXIN I.V.?
The dosage of PRIMAXIN I.V. in adult patients should be based onsuspected or confirmed pathogen susceptibility.
For adult patients with normal renal function (creatinine clearance of greater than or equal to 90 mL/min), the recommended dosage regimens are: 500 mg every 6 hours OR 1000 mg every 8 hours OR 1000 mg every 6 hours.
Is it safe for me to take PRIMAXIN I.V.?
PRIMAXIN I.V. is a safe and effective treatment when used for FDA licensed indications. However, like all medications, they may give you unwanted side effects. You should always discuss potential side effects with your physician to ensure the medication is suitable and right for you. You should not use this medication if you have a known hypersensitivity to any component of PRIMAXIN.
PRIMAXIN I.V. Common Side Effects
Common side effects of PRIMAXIN I.V.:
- Phlebitis
- Nausea
- Diarrhea
- Vomiting
- Rash
- Pain at the injection site
- Fever
- Hypotension
- Seizures
- Dizziness
- Itching
- Fatigue
PRIMAXIN I.V. Serious Side Effects
Serious side effects are rare with PRIMAXIN I.V.. Inform your physician:
- If you have central nervous system disorders such as stroke or history of seizures. Seizures have been reported during treatment with PRIMAXIN and with closely related antibacterial drugs
- If you are taking valproic acid or sodium valproate. Valproic acid concentrations in the blood may drop below the therapeutic range upon co-administration with PRIMAXIN. If treatment with PRIMAXIN is necessary and continued, alternative or supplemental anti-convulsant medication to prevent and/or treat seizures may be needed
Effects of other drugs, drug classes and over-the-counter products on PRIMAXIN I.V.
The following medications may interact with PRIMAXIN I.V.:
- Ganciclovir: Generalized seizures have been reported in patients who received ganciclovir. Do not co-administer unless benefit outweighs risk
- Probenecid: Concomitant administration of PRIMAXIN and probenecid results in increases in the plasma level and half-life of imipenem. Concomitant administration is not recommended
- Valproic acid/divalproex sodium: Concomitant use with PRIMAXIN is generally not recommended. Consider other antibacterial drugs to treat infections in patients whose seizures are well-controlled on valproic acid or divalproex sodium
Who makes PRIMAXIN I.V.?
Merck & Co., Inc.
Is PRIMAXIN I.V. safe in pregnancy?
It is not known if PRIMAXIN I.V. can harm your unborn baby. PRIMAXIN I.V. should only be used during pregnancy if the benefit to you is worth the possible risk to your baby.
What to do if you missed your PRIMAXIN I.V. dose
The FDA's medical product safety reporting program for health professionals, patients and consumers.
Learn more about reporting side effectsDrug Savings Tips
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Medical Disclaimer
NowPatient has taken all reasonable steps to ensure that all material is factually accurate, complete, and current. However, the knowledge and experience of a qualified healthcare professional should always be sought after instead of using the information on this page. Before taking any drug, you should always speak to your doctor or another qualified healthcare provider.
The information provided here about medications is subject to change and is not meant to include all uses, precautions, warnings, directions, drug interactions, allergic reactions, or negative effects. The absence of warnings or other information for a particular medication does not imply that the medication or medication combination is appropriate for all patients or for all possible purposes.
Things to know
What is PRIMAXIN used to treat?
What bacteria does PRIMAXIN cover?
What type of antibiotic is PRIMAXIN?
What are the side effects of primaxin IV?
Is PRIMAXIN expensive?
What is the action of Primaxin IV?
Is imipenem a strong antibiotic?
What is the generic name for PRIMAXIN?
What bacteria does imipenem cover?
Does imipenem treat MRSA?
Can imipenem treat sepsis?
Does PRIMAXIN cover Pseudomonas?
What is the infusion rate for PRIMAXIN?
What is IV imipenem used for?
What are the side effects of Primaxin IV?
What bacteria does imipenem cover?
Is imipenem used for sepsis?
How do you administer imipenem IV?
Can imipenem be given IV push?
Does imipenem treat UTI?
Is imipenem a penicillin?
What is the generic name for PRIMAXIN?
How long do you take imipenem for UTI?
How often is PRIMAXIN taken?
What strength is PRIMAXIN?
What should I assess before giving PRIMAXIN?
Is imipenem expensive?
How long is the course of imipenem?
Is PRIMAXIN a broad spectrum antibiotic?
What class of antibiotic is PRIMAXIN?
What is another name for Primaxin?
What bacteria does imipenem not cover?
Does imipenem cover MRSA?
Is imipenem effective against MRSA?
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