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Imipenem/Cilastatin is available as an IV injection that contains 500 mg imipenem (anhydrous equivalent) and 500 mg cilastatin (free acid equivalent).

Imipenem/Cilastatin is a combination of imipenem, a penem antibacterial, and cilastatin, a renal dehydropeptidase inhibitor, indicated for the treatment of the following serious infections caused by designated susceptible bacteria:

• Lower respiratory tract infections
• Urinary tract infections
• Intra-abdominal infections
• Gynecologic infections
• Bacterial septicemia
• Bone and joint infections
• Skin and skin structure infections
• Endocarditis

Imipenem/Cilastatin is a combination of imipenem, a penem
antibacterial, and cilastatin, a renal dehydropeptidase inhibitor. It works similar to the other beta-lactam antibiotics, which is to inactivate the penicillin-binding proteins (PBP) and cause cell wall lysis, or interfere with cell wall formation.

The dosage of Imipenem/Cilastatin in adult patients should be based onsuspected or confirmed pathogen susceptibility.
For adult patients with normal renal function (creatinine clearance of greater than or equal to 90 mL/min), the recommended dosage regimens are: 500 mg every 6 hours OR 1000 mg every 8 hours OR 1000 mg every 6 hours.

Imipenem/Cilastatin is a safe and effective treatment when used for FDA licensed indications. However, like all medications, they may give you unwanted side effects. You should always discuss potential side effects with your physician to ensure the medication is suitable and right for you. You should not use this medication if you have a known hypersensitivity to any component of PRIMAXIN.

Common side effects of Imipenem/Cilastatin:

• Phlebitis
• Nausea
• Diarrhea
• Vomiting
• Rash
• Pain at the injection site
• Fever
• Hypotension
• Seizures
• Dizziness
• Itching
• Fatigue

Serious side effects are rare with Imipenem/Cilastatin. Inform your physician:

• If you have central nervous system disorders such as stroke or history of seizures. Seizures have been reported during treatment with PRIMAXIN and with closely related antibacterial drugs
• If you are taking valproic acid or sodium valproate. Valproic acid concentrations in the blood may drop below the therapeutic range upon co-administration with PRIMAXIN. If treatment with PRIMAXIN is necessary and continued, alternative or supplemental anti-convulsant medication to prevent and/or treat seizures may be needed

The following medications may interact with Imipenem/Cilastatin:

• Ganciclovir: Generalized seizures have been reported in patients who received ganciclovir. Do not co-administer unless benefit outweighs risk
• Probenecid: Concomitant administration of PRIMAXIN and probenecid results in increases in the plasma level and half-life of imipenem. Concomitant administration is not recommended
• Valproic acid/divalproex sodium: Concomitant use with PRIMAXIN is generally not recommended. Consider other antibacterial drugs to treat infections in patients whose seizures are well-controlled on valproic acid or divalproex sodium

Various FDA-approved generic manufacturers

It is not known if Imipenem/Cilastatin can harm your unborn baby. Imipenem/Cilastatin should only be used during pregnancy if the benefit to you is worth the possible risk to your baby.

• Primaxin I.v.