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Pirfenidone is available as a 267 mg oral capsule.

Pirfenidone is an antifibrotic agent that is used to treat idiopathic pulmonary fibrosis (IPF).

It is not exactly clear how Pirfenidone works, but it lessens the chemicals that cause inflammation and fibrosis (scarring) in the lungs. As a result, your lungs don’t scar as quickly and your breathing doesn’t worsen as much over time.

When first starting Pirfenidone, you’ll need to follow a specific dose schedule.

• Week 1: Take 267 mg (1 pill) by mouth three times daily
• Week 2: Take 534 mg (2 pills) by mouth three times daily
• Week 3 and beyond: Take 801 (3 pills) by mouth three times daily. Pirfenidone is also available as a 801 mg tablet, so you may eventually get to switch to 1 pill a day once you reach this maintenance dose

Pirfenidone is a safe and effective treatment when used for FDA licensed indications. However, like all medications, they may give you unwanted side effects. You should always discuss potential side effects with your physician to ensure the medication is suitable and right for you.

Common side effects of Pirfenidone:

• Nausea
• Rash
• Stomach pain or discomfort
• Common cold symptoms
• Diarrhea
• Tiredness
• Headache
• Indigestion
• Dizziness
• Vomiting
• Poor appetite

Serious side effects are rare with Pirfenidone. Contact your healthcare provider immediately if you experience any of the following.

• Liver injury: yellowing of the skin or eyes, dark-colored urine, pain on the right side of your torso, more bleeding or bruising, tiredness that doesn’t go away
  Severe sunburn or rash

The following medications may interact with Pirfenidone:

• Moderate (e.g., ciprofloxacin) and strong inhibitors of CYP1A2 (e.g. fluvoxamine) increase systemic exposure of Pirfenidone and may alter the adverse reaction profile of Pirfenidone. Discontinue fluvoxamine prior to administration of Pirfenidone or reduce to one capsule three times a day
• Consider dosage reduction with use of ciprofloxacin

Various FDA-approved generic manufacturers

It is not known if Pirfenidone will harm your unborn baby. Tell your healthcare provider if you are pregnant or plan to become pregnant while using Pirfenidone.

• Esbriet