Pioglitazone-metformin Generic

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*Based on the difference between the U&C price submitted and the price the patient paid, as of April 2023.

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  2. Pioglitazone-Metformin
    Generic for Actoplus Met
    22 tablets $9 USD
    Save $90.88
  3. Pioglitazone-Metformin
    Generic for Actoplus Met
    30 tablets $10.8 USD
    Save $125.40
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Do you need a prescription for pioglitazone-metformin?

Yes, pioglitazone-metformin is only available with a valid physician Rx.

How much is pioglitazone-metformin without Insurance in the US?

Our website gives two competitive savings options to US customers who wish to purchase pioglitazone-metformin, as either a brand or generic, if available. The first is access to medications through our mail-order online pharmacy. The second is by using the Now Patient Rx Advantage Card, which can be used in over 65,000 pharmacies nationwide, across America. If you are insured, then in most cases, the cash price will be significantly cheaper than the copay.

What will my out-of-pocket cost be for pioglitazone-metformin in the US?

There are no out-of-pocket (OOP) costs because we are currently only offering a cash-based option to purchase medications.

Is Now Patient a pioglitazone-metformin savings card?

Yes. Save up to 90% on your pioglitazone-metformin with the FREE Now Patient Rx Advantage card*.
*Based on the difference between the U&C submitted by the pharmacy and the price the patients pay.

Can you handle Rx transfers for home delivery in the US?

Yes. If you use the mail-order online pharmacy option, then we can handle requests by you to have your prescription transferred to our pharmacy for home delivery. We can even help you manage your refills by giving you timely reminders, so you do not run out of your medication.

Is Now Patient a pioglitazone-metformin coupon provider in the US?

No. Now Patient does not provide pioglitazone-metformin coupons or FREE pioglitazone-metformin samples.

Do you accept commercial, Medicare or Medicaid coverage for pioglitazone-metformin in the US?

No. Currently, we only offer cash-based options for purchase, therefore we do not require your insurance benefit details. In the future, our plan is to be able to handle commercial insurance, Medicare and Medicaid including cases where you have multiple health plans that provide benefit coverage (e.g. Medicaid and Commercial). We also anticipate being able to handle more complex scenarios such as using primary insurance combined with a manufacturer copay assistance program.

Does Now Patient work with Medicare?

Our cash-based prices for medications are typically cheaper than Medicare copays. We do not bill Medicare Part D (standalone drug coverage) or Medicare Advantage (combined health and drug coverage). When you purchase your medication from Now Patient, you will be doing so out of your pocket. The spend will not count towards your plan deductibles or gaps.

Does Now Patient work with Commercial Insurance?

Our cash-based prices for medications are typically cheaper than commercial plan copays. We do not bill your commercial plan. When you purchase your medication from Now Patient, you will be doing so out of your pocket. The spend will not count towards your plan deductibles or gaps.

What should you do if you use too much pioglitazone-metformin?


Call your doctor right away or seek immediate medical attention if your symptoms do not improve or they become worse after using pioglitazone-metformin. You can also call 800-222-1222 to reach the American Association of Poison Control Centers or use its online resource if you think you’ve used too much pioglitazone-metformin. But if you have severe symptoms, call 911 (or your local emergency number) immediately or go to the nearest emergency room.


If you think it is an emergency, call 999 or find your nearest A&E
If you need help now, but it’s not an emergency go to 111.nhs.uk or call 111. Alternatively you can speak to one of our pharmacists or use the Now Patient app to make an appointment with your GP.

What should I do if I miss my dose?

There are occasions when people forget to take their medication at correct prescribed times. This may not only have an effect on potentially making the medication less effective but it may also inadvertently lead to taking doses too close together, thereby increasing the risks of side effects.

Click here to find out what to do if you forgot to take your medication

What is generic pioglitazone-metformin?

Generic pioglitazone-metformin refers to the non-brand-name version of the medication. It contains the same active ingredients as the brand-name drug but is typically less expensive.

FDA approval of pioglitazone-metformin

Pioglitazone-metformin is approved by the U.S. Food and Drug Administration (FDA) for the treatment of type 2 diabetes mellitus.

Active ingredients of pioglitazone-metformin

Pioglitazone-metformin is a combination therapy containing two active ingredients: pioglitazone hydrochloride and metformin hydrochloride.

US brand name of pioglitazone-metformin and manufacturer

Pioglitazone-metformin is available under various brand names in the US, including Actoplus Met, Actoplus Met XR, and Duetact. These medications are manufactured by different pharmaceutical companies.

UK brand name of pioglitazone-metformin and manufacturer

In the UK, pioglitazone-metformin is available under various brand names, and the manufacturers may vary.

Prescription requirement for pioglitazone-metformin

A prescription (Rx) is required for pioglitazone-metformin in both the US and the UK.

Availability of pioglitazone-metformin in the UK with NHS prescription

Pioglitazone-metformin is available in the UK with an NHS prescription.

Conditions treated by pioglitazone-metformin

Pioglitazone-metformin is used to treat type 2 diabetes mellitus, particularly when diet and exercise alone are insufficient to control blood sugar levels. It helps to improve insulin sensitivity and decreases glucose production in the liver, helping to reduce the risk of hyperglycemia (high blood sugar) and improve glycemic control.

How does pioglitazone-metformin work?

Pioglitazone-metformin combines two different classes of medications: thiazolidinediones (pioglitazone) and biguanides (metformin). Pioglitazone helps improve insulin sensitivity in the body, while metformin reduces glucose production and improves glucose uptake by the muscles.

Forms of pioglitazone-metformin available

Pioglitazone-metformin is available as oral immediate-release tablets and oral extended-release tablets.

Dosage of pioglitazone-metformin

The dosage of pioglitazone-metformin may vary depending on individual patient factors and response to treatment. It is important to follow the prescribed dosage instructions provided by the healthcare provider.

Directions for pioglitazone-metformin use

Pioglitazone-metformin should be taken exactly as directed by the healthcare provider. It is usually taken with meals to reduce the risk of gastrointestinal side effects. The tablets should be swallowed whole with a glass of water and should not be chewed or crushed.

Warnings and precautions for pioglitazone-metformin

  • Pioglitazone-metformin should not be used in patients with severe kidney disease, liver disease, or heart problems such as congestive heart failure (call your doctor right away if you have shortness of breath, swelling, or rapid weight gain
  • It may cause or exacerbate heart failure, so it’s important to monitor for signs and symptoms of heart failure during treatment
  • Before using this medication, tell your doctor if you have blood problems, such as anemia, or vitamin B12 deficiency, swelling (edema), eye problems such as (macular edema), bladder cancer, metabolic acidosis, or ketoacidosis
  • Pioglitazone-metformin does not usually cause low blood sugar (hypoglycemia. Low blood glucose may occur when prescribed with other treatments for diabetes, such as insulin or a sulfonylurea
  • Pioglitazone-metformin hydrochloride is not recommended for the treatment of type 1 diabetes

Interactions with other drugs

Pioglitazone-metformin may have drug interactions with certain medications, including other oral antidiabetic drugs, insulin, gemfibrozil, rifampin. It is important to inform your healthcare provider about all the prescription drugs you are taking including vitamins and herbal supplements, to avoid potential interactions.

Use of pioglitazone-metformin during pregnancy

Pioglitazone-metformin should not be used during pregnancy. Consultation with a healthcare provider is necessary to discuss alternative treatment options.

Use of pioglitazone-metformin while breastfeeding

Pioglitazone-metformin is not recommended while breastfeeding. Consultation with a healthcare provider is necessary to discuss the specific situation.

Possible side effects of pioglitazone-metformin

In clinical trials common side effects of pioglitazone-metformin may include weight gain, edema (fluid retention), gastrointestinal disturbances, and headache. Serious side effects are rare but can include the risk of lactic acidosis (a rare but potentially life-threatening condition, call your doctor immediately if you have unusual muscle pain, stomach pain, trouble breathing, dizziness, or weakness or tiredness ) and heart failure. Read the medication guide provided and speak to your doctor for medical advice about your medical condition when taking this medication.

Similar drugs to pioglitazone-metformin

Other combination medications for treating type 2 diabetes include empagliflozin/metformin, glipizide/metformin, and saxagliptin/metformin.



Now Patient has taken all reasonable steps to ensure that all material is factually accurate, complete, and current. However, the knowledge and experience of a qualified healthcare professional should always be sought after instead of using the information in this page. Before taking any drug, you should always speak to your doctor or another qualified healthcare provider.

The information provided here about medications is subject to change and is not meant to include all uses, precautions, warnings, directions, drug interactions, allergic reactions, or negative effects. The absence of warnings or other information for a particular medication does not imply that the medication or medication combination is appropriate for all patients or for all possible purposes.

Stefano Mirabello Medical Reviewer
Pharmacist / B.Pharm
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