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Pioglitazone/Metformin is available as a tablet containing 15 mg, pioglitazone/500 mg metformin HCl or 15 mg, pioglitazone/850 mg metformin.

Pioglitazone/Metformin made up of two medications that help lower blood sugar in type 2 diabetics.

Pioglitazone/Metformin contains metformin which is a biguanide that lowers the amount of sugar your body makes or absorbs, and allows you to use your body’s natural insulin better. It also contains pioglitazone, which is a thiazolidinedione that helps your body use insulin better to lower your blood sugar.

The typical starting dose of ACTOPLUSMET is 15 mg/500 mg by mouth twice per day or 15 mg/850 mg (Pioglitazone/Metformin) by mouth once per day with meals. If needed, your physician will raise your dose slowly depending on how you respond to the medication.

Pioglitazone/Metformin is a safe and effective treatment when used for FDA licensed indications. However, like all medications, they may give you unwanted side effects. You should always discuss potential side effects with your physician to ensure the medication is suitable and right for you. You should not use Pioglitazone/Metformin if you have heart failure, severe kidney impairment, or diabetic ketoacidosis.

Common side effects of Pioglitazone/Metformin include:

• Cold-like symptoms
• Swelling
• Diarrhea
• Headache
• Weight gain

Serious side effects are rare with Pioglitazone/Metformin. Contact your healthcare provider immediately if you experience any of the following.

• Heart failure: shortness of breath, unusual swelling, tiredness, sudden weight gain
• Lactic acidosis: fast breathing, fast or slow heartbeat, heartbeat that does not feel normal, very upset stomach or throwing up, feeling very sleepy, shortness of breath, feeling very tired or weak, dizziness, feeling cold, muscle pain
• Bladder cancer: pain while you urinate, constant need to urinate, and blood in your urine
• Liver problems: nausea or vomiting, stomach pain, unusual tiredness, loss of appetite, dark urine, yellowing of your skin or the whites of your eyes
• Diabetic eye disease with swelling (macular edema): blurred vision, changes in vision

The following medications may interact with Pioglitazone/Metformin:

• Strong CYP2C8 inhibitors such as gemfibrozil increase the levels and effects of pioglitazone. Topiramate and rifampin may decrease pioglitazone
• levels and effects
• Drugs that reduce metformin clearance such as ranolazine,vandetanib, dolutegravir, and cimetidine may increase the levels and effects of metformin.
• Alcohol
• Insulin secretagogues or insulin use may increase the risk for hypoglycemia

Various FDA-approved generic manufacturers

It is not known if Pioglitazone/Metformin will harm your unborn baby. If you become pregnant while receiving Pioglitazone/Metformin, talk to your healthcare provider.

• Actoplus Met