ACTOPLUS MET
Used for Type 2 Diabetes
NowPatient helps you obtain your ACTOPLUS MET prescription for free or at low-cost. Drug savings programs are suitable for individuals who are insured, don't have insurance or are underinsured and can't afford your medicine.
Manufactured by Takeda Pharmaceuticals
*You can pay as little as $0 per fill using Drug Coupons or Patient Assistance Programs. Subject to applicability & eligibility requirements.
This content is intended for US audiences only
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ACTOPLUS MET key facts
What is ACTOPLUS MET?
ACTOPLUS MET is the brand name for pioglitazone hydrochloride and metformin and is available as an oral tablet.
What dosages is ACTOPLUS MET available in?
ACTOPLUS MET is available as a tablet containing 15 mg, pioglitazone/500 mg metformin HCl or 15 mg, pioglitazone/850 mg metformin.
What is ACTOPLUS MET used for?
ACTOPLUS MET made up of two medications that help lower blood sugar in type 2 diabetics.
How does ACTOPLUS MET work?
ACTOPLUS MET contains metformin which is a biguanide that lowers the amount of sugar your body makes or absorbs, and allows you to use your body’s natural insulin better. It also contains pioglitazone, which is a thiazolidinedione that helps your body use insulin better to lower your blood sugar.
How do I take ACTOPLUS MET?
The typical starting dose of ACTOPLUSMET is 15 mg/500 mg by mouth twice per day or 15 mg/850 mg (pioglitazone/metformin) by mouth once per day with meals. If needed, your physician will raise your dose slowly depending on how you respond to the medication.
Is it safe for me to take ACTOPLUS MET?
ACTOPLUS MET is a safe and effective treatment when used for FDA licensed indications. However, like all medications, they may give you unwanted side effects. You should always discuss potential side effects with your physician to ensure the medication is suitable and right for you. You should not use ACTOPLUS MET if you have heart failure, severe kidney impairment, or diabetic ketoacidosis.
ACTOPLUS MET Common Side Effects
Common side effects of ACTOPLUS MET include:
- Cold-like symptoms
- Swelling
- Diarrhea
- Headache
- Weight gain
ACTOPLUS MET Serious Side Effects
Serious side effects are rare with ACTOPLUS MET. Contact your healthcare provider immediately if you experience any of the following.
- Heart failure: shortness of breath, unusual swelling, tiredness, sudden weight gain
- Lactic acidosis: fast breathing, fast or slow heartbeat, heartbeat that does not feel normal, very upset stomach or throwing up, feeling very sleepy, shortness of breath, feeling very tired or weak, dizziness, feeling cold, muscle pain
- Bladder cancer: pain while you urinate, constant need to urinate, and blood in your urine
- Liver problems: nausea or vomiting, stomach pain, unusual tiredness, loss of appetite, dark urine, yellowing of your skin or the whites of your eyes
- Diabetic eye disease with swelling (macular edema): blurred vision, changes in vision
Effects of other drugs, drug classes and over-the-counter products on ACTOPLUS MET
The following medications may interact with ACTOPLUS MET:
- Strong CYP2C8 inhibitors such as gemfibrozil increase the levels and effects of pioglitazone. Topiramate and rifampin may decrease pioglitazone
- levels and effects
- Drugs that reduce metformin clearance such as ranolazine,vandetanib, dolutegravir, and cimetidine may increase the levels and effects of metformin.
- Alcohol
- Insulin secretagogues or insulin use may increase the risk for hypoglycemia
Who makes ACTOPLUS MET?
Takeda Pharmaceuticals
Is ACTOPLUS MET safe in pregnancy?
It is not known if ACTOPLUS MET will harm your unborn baby. If you become pregnant while receiving ACTOPLUS MET, talk to your healthcare provider.
The FDA's medical product safety reporting program for health professionals, patients and consumers.
Learn more about reporting side effects in the USDrug Savings Guide
A practical guide to saving money and receiving support with prescription costs
How can NowPatient help me to lower the cost of my ACTOPLUS MET prescription?
After you create a FREE account with NowPatient, you will have access to 4 programs that can help lower the cost of your ACTOPLUS MET prescription
Applicability to each program will be dependent on your insurance status.
How do the NowPatient ACTOPLUS MET savings programs work?
After you have created your FREE account with NowPatient, you can access the various programs from your account dashboard. Each program has clear instructions on how to check your eligibility. You can see how the process works by clicking on the feature link below and seeing the ‘How it works’ steps.
Drug Coupon and Patient Assistance Programs require an eligibility quiz to be completed.
Are the NowPatient ACTOPLUS MET savings programs suitable for everyone, regardless of insurance status?
No. Each program has its own eligibility and applicability requirements. The table below shows if a program is available to you, based on your insurance status.
| Rx Advantage Card* for ACTOPLUS MET | Canadian Prescription Savings* for ACTOPLUS MET | ACTOPLUS MET Drug Coupon* | ACTOPLUS MET Patient Assistance Program* | |
| Insured (federal, state or government) | Available | Available | Not Available | Available If Offered by Pharmaceutical Company |
| Insured (Commercial or Private) | Available | Available | Available If Offered by Pharmaceutical Company | Available If Offered by Pharmaceutical Company |
| Uninsured | Available | Available | Not Available | Available If Offered by Pharmaceutical Company |
| Insured but without pharmacy benefit or drug coverage | Available | Available | Not Available | Available If Offered by Pharmaceutical Company |
*This is not insurance.
Are the NowPatient drug savings programs suitable for brand and generic versions of ACTOPLUS MET?
No. Each program has applicability requirements. Please see below
| Rx Advantage Card* for ACTOPLUS MET | Canadian Prescription Savings* for ACTOPLUS MET | ACTOPLUS MET Drug Coupon* | ACTOPLUS MET Patient Assistance Program* | |
| Brand | Yes | Yes | Yes, If Offered by Pharmaceutical Company | Yes, If Offered by Pharmaceutical Company |
| Generic | Yes | Yes | No | No |
*This is not insurance.
If you have Medicare Part D or Medicare Advantage and none of the ACTOPLUS MET savings options are applicable or affordable for me, what can you do?
If you are insured with Medicare and the ACTOPLUS MET drug savings options are not applicable to you and still remain unaffordable, then you can check Medicaid eligibility in your state by following the instructions at HealthCare.gov.
The government site is easy to use and after you have selected your state, it will navigate you to the appropriate contact point to make the application. State Medicaid programs may cover the full cost of your medication.
People who qualify for both Medicare and Medicaid are called ‘dual eligibles’.
If you are denied Medicaid for ACTOPLUS MET, and you are still unable to afford your copay or co-insurance element (for example if you are in the coverage gap or Donut Hole) then you may be eligible for a federal support program like Low Income Subsidy. To be eligible for Low Income Subsidy, you need to be a resident in one of the 50 States or the District of Columbia. You can check eligibility online at SSA Medicare D Extra Help. You can also call Social Security at 1-800-772-1213 (TTY 1-800-325-0778).
I am uninsured or underinsured and none of the ACTOPLUS MET prescription saving options are applicable or affordable for me, what can I do?
If you are uninsured or underinsured (for example, ACTOPLUS MET is not covered by your plan) and the drug savings options are not applicable or still unaffordable, then you can check Medicaid eligibility in your state by following the instructions at HealthCare.gov.
The government site is easy to use and you can select your state and it will navigate you to the appropriate contact point to make the application. State Medicaid programs may cover the full cost of your medication.
If you are denied and all else fails, and if you have been prescribed ACTOPLUS MET for an FDA-approved indication, you can call the pharmaceutical company to see if they have any other assistance programs.
I am commercially or privately insured and none of the ACTOPLUS MET prescription saving options are applicable or affordable for me, what can I do?
If your medication is not covered by your plan, you can you can appeal your insurance company’s decision. Sometimes, a formal appeal can result in the drug being covered if it is deemed medically necessary.
If you cannot afford your copay, then you can check Medicaid eligibility in your state by following the instructions at HealthCare.gov.
However, being privately insured might complicate your eligibility for Medicaid, as having private insurance may be considered in the financial eligibility assessment.
The government site is easy to use and you can select your state and it will navigate you to the appropriate contact point to make the application. If you qualify, state Medicaid may cover the full cost of your medication.
If I have federal, state or commercial insurance and none of the ACTOPLUS MET prescription saving options are applicable or affordable for me, are there any other support organisations that can help me with my co-insurance or copay?
If you have already tried Medicaid and received a denial letter or if you are insured with Medicare and have been denied Low-Income Subsidy, then you can try one of the following organizational support programs:
1. Patient Access Network Foundation (PAN) assistance for ACTOPLUS MET
If you are having trouble paying for your ACTOPLUS MET medication due to unaffordable copays or deductibles, the Patient Access Network Foundation (PAN), may be able to assist you. To qualify for PAN assistance for ACTOPLUS MET you will need to meet one or all of the following criteria:
- Your income is below 400% of the federal poverty level
- ACTOPLUS MET is prescribed for an approved FDA indication
- You live in and receive treatment in the United States or U.S. territories, even if you do not have U.S. citizenship
- You have Medicare insurance coverage that covers ACTOPLUS MET
- If ACTOPLUS MET is listed on PAN’s list of covered medications
You can check the Patient Access Network Foundation Website for more information.
2. HealthWell Foundation Copay Program for ACTOPLUS MET
If you are having trouble paying for your ACTOPLUS MET medication due to unaffordable copays or deductibles, the HealthWell Foundation Copay Program may be able to assist you. To qualify for assistance for ACTOPLUS MET you will need to meet the following criteria:
- You live in and are being treated in the United States
- You are insured and your plan covers ACTOPLUS MET
- If ACTOPLUS MET is listed on the HealthWell Foundation’s list of covered medications
You can check the HealthWell Foundation Website for more information.
3. Patient Advocate Foundation Co-Pay Relief Program for ACTOPLUS MET
Patient Advocate Foundation’s Co-Pay Relief program exists to help reduce the financial distress you or your family may face when paying for your ACTOPLUS MET treatment. If you qualify and can demonstrate the need, the foundation will provide you with direct payment covering co-pays, co-insurance, and deductibles. To qualify for assistance for ACTOPLUS MET you will need to meet the following criteria:
- You must be currently insured and have coverage for ACTOPLUS MET
- You must have a confirmed diagnosis and treatment plan
- You must reside and receive treatment in the United States
- Your Income must fall at or below 300% or 400% of the Federal Poverty Guideline (FPG) with consideration for the Cost of Living Index (COLI) and number in the household
- Applications can also be completed by contacting the program sponsor, toll-free at 866-512-3861.
You can check the Patient Advocate Foundation Website for more information.
Medical Disclaimer
NowPatient has taken all reasonable steps to ensure that all material is factually accurate, complete, and current. However, the knowledge and experience of a qualified healthcare professional should always be sought after instead of using the information on this page. Before taking any drug, you should always speak to your doctor or another qualified healthcare provider.
The information provided here about medications is subject to change and is not meant to include all uses, precautions, warnings, directions, drug interactions, allergic reactions, or negative effects. The absence of warnings or other information for a particular medication does not imply that the medication or medication combination is appropriate for all patients or for all possible purposes.
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