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Manufactured by Takeda Pharmaceuticals

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Jamie Winn NowPatientGreen tick
Updated on 26 Apr 2024

ACTOPLUS MET Uses, Side Effects, Interactions, Warnings & Dosing



ACTOPLUS MET is the brand name for pioglitazone hydrochloride and metformin and is available as an oral tablet.

What dosages is ACTOPLUS MET available in?

What dosages is ACTOPLUS MET available in?

ACTOPLUS MET is available as a tablet containing 15 mg, pioglitazone/500 mg metformin HCl or 15 mg, pioglitazone/850 mg metformin.

What is ACTOPLUS MET used for?

What is ACTOPLUS MET used for?

ACTOPLUS MET made up of two medications that help lower blood sugar in type 2 diabetics.

How does ACTOPLUS MET work?

How does ACTOPLUS MET work?

ACTOPLUS MET contains metformin which is a biguanide that lowers the amount of sugar your body makes or absorbs, and allows you to use your body’s natural insulin better. It also contains pioglitazone, which is a thiazolidinedione that helps your body use insulin better to lower your blood sugar.

How do I take ACTOPLUS MET?

How do I take ACTOPLUS MET?

The typical starting dose of ACTOPLUSMET is 15 mg/500 mg by mouth twice per day or 15 mg/850 mg (pioglitazone/metformin) by mouth once per day with meals. If needed, your physician will raise your dose slowly depending on how you respond to the medication.

Is it safe for me to take ACTOPLUS MET?

Is it safe for me to take ACTOPLUS MET?

ACTOPLUS MET is a safe and effective treatment when used for FDA licensed indications. However, like all medications, they may give you unwanted side effects. You should always discuss potential side effects with your physician to ensure the medication is suitable and right for you. You should not use ACTOPLUS MET if you have heart failure, severe kidney impairment, or diabetic ketoacidosis.

ACTOPLUS MET Common Side Effects

ACTOPLUS MET Common Side Effects

Common side effects of ACTOPLUS MET include:

  • Cold-like symptoms
  • Swelling
  • Diarrhea
  • Headache
  • Weight gain
ACTOPLUS MET Serious Side Effects

ACTOPLUS MET Serious Side Effects

Serious side effects are rare with ACTOPLUS MET. Contact your healthcare provider immediately if you experience any of the following.

  • Heart failure: shortness of breath, unusual swelling, tiredness, sudden weight gain
  • Lactic acidosis: fast breathing, fast or slow heartbeat, heartbeat that does not feel normal, very upset stomach or throwing up, feeling very sleepy, shortness of breath, feeling very tired or weak, dizziness, feeling cold, muscle pain
  • Bladder cancer: pain while you urinate, constant need to urinate, and blood in your urine
  • Liver problems: nausea or vomiting, stomach pain, unusual tiredness, loss of appetite, dark urine, yellowing of your skin or the whites of your eyes
  • Diabetic eye disease with swelling (macular edema): blurred vision, changes in vision
Effects of other drugs, drug classes and over-the-counter products on ACTOPLUS MET

Effects of other drugs, drug classes and over-the-counter products on ACTOPLUS MET

The following medications may interact with ACTOPLUS MET:

  • Strong CYP2C8 inhibitors such as gemfibrozil increase the levels and effects of pioglitazone. Topiramate and rifampin may decrease pioglitazone
  • levels and effects
  • Drugs that reduce metformin clearance such as ranolazine,vandetanib, dolutegravir, and cimetidine may increase the levels and effects of metformin.
  • Alcohol
  • Insulin secretagogues or insulin use may increase the risk for hypoglycemia


Takeda Pharmaceuticals

Is ACTOPLUS MET safe in pregnancy?

Is ACTOPLUS MET safe in pregnancy?

It is not known if ACTOPLUS MET will harm your unborn baby. If you become pregnant while receiving ACTOPLUS MET, talk to your healthcare provider.


What to do if you missed your ACTOPLUS MET dose

The FDA's medical product safety reporting program for health professionals, patients and consumers.

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NowPatient has taken all reasonable steps to ensure that all material is factually accurate, complete, and current. However, the knowledge and experience of a qualified healthcare professional should always be sought after instead of using the information on this page. Before taking any drug, you should always speak to your doctor or another qualified healthcare provider.

The information provided here about medications is subject to change and is not meant to include all uses, precautions, warnings, directions, drug interactions, allergic reactions, or negative effects. The absence of warnings or other information for a particular medication does not imply that the medication or medication combination is appropriate for all patients or for all possible purposes.

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