Pioglitazone Generic

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*Based on the difference between the U&C price submitted and the price the patient paid, as of April 2023.

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  2. Pioglitazone HCl
    Generic for Actos
    30 tablets $5.4 USD
    Save $69.00
  3. Pioglitazone HCl
    Generic for Actos
    30 tablets $4.8 USD
    Save $69.60
  4. Pioglitazone HCl
    Generic for Actos
    60 tablets $6.6 USD
    Save $142.20
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Do you need a prescription for pioglitazone?

Yes, pioglitazone is only available with a valid physician Rx.

How much is pioglitazone without Insurance in the US?

Our website gives two competitive savings options to US customers who wish to purchase pioglitazone, as either a brand or generic, if available. The first is access to medications through our mail-order online pharmacy. The second is by using the Now Patient Rx Advantage Card, which can be used in over 65,000 pharmacies nationwide, across America. If you are insured, then in most cases, the cash price will be significantly cheaper than the copay.

What will my out-of-pocket cost be for pioglitazone in the US?

There are no out-of-pocket (OOP) costs because we are currently only offering a cash-based option to purchase medications.

Is Now Patient a pioglitazone savings card?

Yes. Save up to 90% on your pioglitazone with the FREE Now Patient Rx Advantage card*.
*Based on the difference between the U&C submitted by the pharmacy and the price the patients pay.

Can you handle Rx transfers for home delivery in the US?

Yes. If you use the mail-order online pharmacy option, then we can handle requests by you to have your prescription transferred to our pharmacy for home delivery. We can even help you manage your refills by giving you timely reminders, so you do not run out of your medication.

Is Now Patient a pioglitazone coupon provider in the US?

No. Now Patient does not provide pioglitazone coupons or FREE pioglitazone samples.

Do you accept commercial, Medicare or Medicaid coverage for pioglitazone in the US?

No. Currently, we only offer cash-based options for purchase, therefore we do not require your insurance benefit details. In the future, our plan is to be able to handle commercial insurance, Medicare and Medicaid including cases where you have multiple health plans that provide benefit coverage (e.g. Medicaid and Commercial). We also anticipate being able to handle more complex scenarios such as using primary insurance combined with a manufacturer copay assistance program.

Does Now Patient work with Medicare?

Our cash-based prices for medications are typically cheaper than Medicare copays. We do not bill Medicare Part D (standalone drug coverage) or Medicare Advantage (combined health and drug coverage). When you purchase your medication from Now Patient, you will be doing so out of your pocket. The spend will not count towards your plan deductibles or gaps.

Does Now Patient work with Commercial Insurance?

Our cash-based prices for medications are typically cheaper than commercial plan copays. We do not bill your commercial plan. When you purchase your medication from Now Patient, you will be doing so out of your pocket. The spend will not count towards your plan deductibles or gaps.

What should you do if you use too much pioglitazone?


Call your doctor right away or seek immediate medical attention if your symptoms do not improve or they become worse after using pioglitazone. You can also call 800-222-1222 to reach the American Association of Poison Control Centers or use its online resource if you think you’ve used too much pioglitazone. But if you have severe symptoms, call 911 (or your local emergency number) immediately or go to the nearest emergency room.


If you think it is an emergency, call 999 or find your nearest A&E
If you need help now, but it’s not an emergency go to 111.nhs.uk or call 111. Alternatively you can speak to one of our pharmacists or use the Now Patient app to make an appointment with your GP.

What should I do if I miss my dose?

There are occasions when people forget to take their medication at correct prescribed times. This may not only have an effect on potentially making the medication less effective but it may also inadvertently lead to taking doses too close together, thereby increasing the risks of side effects.

Click here to find out what to do if you forgot to take your medication

What is generic pioglitazone?

Generic pioglitazone refers to the non-brand-name version of the medication. It contains the same active ingredient as the brand-name drug but is typically less expensive.

FDA approval of pioglitazone

Pioglitazone is approved by the U.S. Food and Drug Administration (FDA) for the treatment of type 2 diabetes mellitus.

Active ingredient of pioglitazone

The active ingredient of pioglitazone is pioglitazone hydrochloride. Pioglitazone is both a PPAR-(peroxisome proliferator-activated receptor) gamma and PPAR-alpha agonist.

US brand name of pioglitazone and manufacturer

Pioglitazone is available under various brand names in the US, including Actos. These medications are manufactured by different pharmaceutical companies.

UK brand name of pioglitazone and manufacturer

In the UK, pioglitazone is available under various brand names, and the manufacturers may vary.

Prescription requirement for pioglitazone

A prescription (Rx) is required for pioglitazone in both the US and the UK.

Availability of pioglitazone in the UK with NHS prescription

Pioglitazone is available in the UK with an NHS prescription.

Conditions treated by pioglitazone

Pioglitazone is used to treat type 2 diabetes mellitus. It helps to improve insulin sensitivity and regulate blood sugar levels.

How does pioglitazone work?

Pioglitazone is a thiazolidinedione used with diet to manage glycemic levels in adults with type 2 diabetes mellitus. It works by increasing the body’s sensitivity to insulin. It helps the body effectively use insulin to lower blood glucose levels.

Forms of pioglitazone available

Pioglitazone is available in the form of oral tablets.

Dosage of pioglitazone

The dosage of pioglitazone may vary depending on individual patient factors and response to treatment. It is important to follow the prescribed dosage instructions provided by the healthcare provider.

Directions for pioglitazone use

Pioglitazone should be taken exactly as directed by the healthcare provider. The tablets should be swallowed whole with a glass of water and can be taken with or without food.

Warnings and precautions for pioglitazone

Interactions with other drugs

Pioglitazone may have an increased risk of drug interactions with certain medications, including other oral antidiabetic drugs, insulin, and certain medications that affect liver function. It is important to inform your healthcare provider about all the prescription drugs you are taking including vitamins and herbal supplements, to avoid potential interactions.

Use of pioglitazone during pregnancy

Pioglitazone should not be used during pregnancy. Consultation with a healthcare provider is necessary to discuss alternative treatment options.

Use of pioglitazone while breastfeeding

Pioglitazone is not recommended while breastfeeding. Consultation with a healthcare provider is necessary to discuss the specific situation.

Possible side effects of pioglitazone

In clinical trials, when compared to placebo, common side effects of pioglitazone included weight gain, fluid retention, headache, and upper respiratory tract infections. Serious adverse effects are rare but can include heart failure, hypoglycemia (low blood sugar), increased cholesterol, liver problems, shortness of breath and bone fractures.

Similar drugs to pioglitazone

Other diabetes drugs used to treat type 2 diabetes include rosiglitazone, metformin, sulfonylureas, and dipeptidyl peptidase-4 (DPP-4) inhibitors.



Now Patient has taken all reasonable steps to ensure that all material is factually accurate, complete, and current. However, the knowledge and experience of a qualified healthcare professional should always be sought after instead of using the information in this page. Before taking any drug, you should always speak to your doctor or another qualified healthcare provider.

The information provided here about medications is subject to change and is not meant to include all uses, precautions, warnings, directions, drug interactions, allergic reactions, or negative effects. The absence of warnings or other information for a particular medication does not imply that the medication or medication combination is appropriate for all patients or for all possible purposes.

Stefano Mirabello Medical Reviewer
Pharmacist / B.Pharm
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