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Navin Khosla NowPatientGreen tick
Updated on 24 Apr 2024

pantoprazole Uses, Side Effects, Interactions, Warnings & Dosing

What dosages is pantoprazole available in?

What dosages is pantoprazole available in?

pantoprazole is available as a 20 mg and 40 mg delayed-release oral tablet and a 40 mg delayed-release oral suspension.

What is pantoprazole used for?

What is pantoprazole used for?

pantoprazole is a PPI that is used to treat:

  • Gastroesophageal reflux disease (GERD)
  • Erosive esophagitis
  • Other medical conditions that cause too much stomach acid (e.g., Zollinger-Ellison syndrome)
How does pantoprazole work?

How does pantoprazole work?

pantoprazole is a proton pump inhibitor (PPI). It lowers the amount of acid in your stomach by blocking the final step of stomach acid production. This helps relieve heartburn and other stomach problems.

How do I take pantoprazole?

How do I take pantoprazole?

pantoprazole is typically taken as 20 mg to 40 mg by mouth once daily.

Is it safe for me to take pantoprazole?

Is it safe for me to take pantoprazole?

pantoprazole is a safe and effective treatment when used for FDA licensed indications. However, like all medications, they may give you unwanted side effects. You should always discuss potential side effects with your physician to ensure the medication is suitable and right for you. You should not use this medication if you have a hatients with known hypersensitivity to any component of the formulation or to substituted benzimidazoles or are taking rilpivirine-containing products.

pantoprazole Common Side Effects

pantoprazole Common Side Effects

Common side effects of pantoprazole:

  • Headache
  • Diarrhea
  • Nausea
  • Belly pain
pantoprazole Serious Side Effects

pantoprazole Serious Side Effects

Serious side effects are rare with pantoprazole. Contact your healthcare provider immediately if you experience any of the following.

  • Severe stomach pain or diarrhea
  • Kidney problems: urinating more or less than usual, fever, poor appetite
  • Lupus symptoms: joint pain, skin rash on arms or cheeks that gets worse in the sunlight
  • Serious skin reactions: blistering, peeling, or bleeding skin, fever, chills
Effects of other drugs, drug classes and over-the-counter products on pantoprazole

Effects of other drugs, drug classes and over-the-counter products on pantoprazole

The following medications may interact with pantoprazole:

  • Atazanavir and nelfinavir: pantoprazole reduces plasma levels of atazanavir and nelfinavir. Concomitant use is not recommended
  • Saquinavir: pantoprazole increases plasma levels of saquinavir. Monitor for toxicity and consider dose reduction of saquinavir
  • May interfere with drugs for which gastric pH affects bioavailability (e.g., ketoconazole, iron salts, ampicillin esters, and digoxin).
  • Patients treated with pantoprazole and digoxin may need to be monitored for increases in digoxin toxicity
  • Co-administration of clopidogrel with 80 mg omeprazole may reduce the pharmacological activity of clopidogrel if given concomitantly or if given 12 hours apart
  • Cilostazol: pantoprazole increases systemic exposure of cilostazol and one of its active metabolites. Consider dose reduction of cilostazol
  • Drugs metabolized by cytochrome P450 (e.g., diazepam, warfarin, phenytoin, cyclosporine, disulfiram, benzodiazepines): PRILOSEC can prolong their elimination. Monitor and determine need for dose adjustments
  • Patients treated with proton pump inhibitors and warfarin may need to be monitored for increases in INR and prothrombin time
  • Combined inhibitor of CYP 2C19 and 3A4 (e.g. voriconazole) may raise omeprazole levels
  • Tacrolimus: pantoprazole may increase serum levels of tacrolimus
  • Methotrexate: pantoprazole may increase serum levels of methotrexate
Who makes pantoprazole?

Who makes pantoprazole?

Various FDA-approved generic manufacturers

Is pantoprazole safe in pregnancy?

Is pantoprazole safe in pregnancy?

Based on animal data, pantoprazole may cause fetal harm. You should talk to your healthcare provider before taking this medication if you are pregnant.


What to do if you missed your pantoprazole dose

The FDA's medical product safety reporting program for health professionals, patients and consumers.

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NowPatient has taken all reasonable steps to ensure that all material is factually accurate, complete, and current. However, the knowledge and experience of a qualified healthcare professional should always be sought after instead of using the information on this page. Before taking any drug, you should always speak to your doctor or another qualified healthcare provider.

The information provided here about medications is subject to change and is not meant to include all uses, precautions, warnings, directions, drug interactions, allergic reactions, or negative effects. The absence of warnings or other information for a particular medication does not imply that the medication or medication combination is appropriate for all patients or for all possible purposes.

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