Orphenadrine Generic

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*Based on the difference between the U&C price submitted and the price the patient paid, as of April 2023.

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  2. Orphenadrine Citrate ER
    Generic for Norflex
    30 extended release tablets $14.1 USD
    Save $39.90
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Do you need a prescription for orphenadrine?

Yes, orphenadrine is only available with a valid physician Rx.

How much is orphenadrine without Insurance in the US?

Our website gives two competitive savings options to US customers who wish to purchase orphenadrine, as either a brand or generic, if available. The first is access to medications through our mail-order online pharmacy. The second is by using the Now Patient Rx Advantage Card, which can be used in over 65,000 pharmacies nationwide, across America. If you are insured, then in most cases, the cash price will be significantly cheaper than the copay.

What will my out-of-pocket cost be for orphenadrine in the US?

There are no out-of-pocket (OOP) costs because we are currently only offering a cash-based option to purchase medications.

Is Now Patient a orphenadrine savings card?

Yes. Save up to 90% on your orphenadrine with the FREE Now Patient Rx Advantage card*.
*Based on the difference between the U&C submitted by the pharmacy and the price the patients pay.

Can you handle Rx transfers for home delivery in the US?

Yes. If you use the mail-order online pharmacy option, then we can handle requests by you to have your prescription transferred to our pharmacy for home delivery. We can even help you manage your refills by giving you timely reminders, so you do not run out of your medication.

Is Now Patient a orphenadrine coupon provider in the US?

No. Now Patient does not provide orphenadrine coupons or FREE orphenadrine samples.

Do you accept commercial, Medicare or Medicaid coverage for orphenadrine in the US?

No. Currently, we only offer cash-based options for purchase, therefore we do not require your insurance benefit details. In the future, our plan is to be able to handle commercial insurance, Medicare and Medicaid including cases where you have multiple health plans that provide benefit coverage (e.g. Medicaid and Commercial). We also anticipate being able to handle more complex scenarios such as using primary insurance combined with a manufacturer copay assistance program.

Does Now Patient work with Medicare?

Our cash-based prices for medications are typically cheaper than Medicare copays. We do not bill Medicare Part D (standalone drug coverage) or Medicare Advantage (combined health and drug coverage). When you purchase your medication from Now Patient, you will be doing so out of your pocket. The spend will not count towards your plan deductibles or gaps.

Does Now Patient work with Commercial Insurance?

Our cash-based prices for medications are typically cheaper than commercial plan copays. We do not bill your commercial plan. When you purchase your medication from Now Patient, you will be doing so out of your pocket. The spend will not count towards your plan deductibles or gaps.

What should you do if you use too much orphenadrine?


Call your doctor right away or seek immediate medical attention if your symptoms do not improve or they become worse after using orphenadrine. You can also call 800-222-1222 to reach the American Association of Poison Control Centers or use its online resource if you think you’ve used too much orphenadrine. But if you have severe symptoms, call 911 (or your local emergency number) immediately or go to the nearest emergency room.


If you think it is an emergency, call 999 or find your nearest A&E
If you need help now, but it’s not an emergency go to 111.nhs.uk or call 111. Alternatively you can speak to one of our pharmacists or use the Now Patient app to make an appointment with your GP.

What should I do if I miss my dose?

There are occasions when people forget to take their medication at correct prescribed times. This may not only have an effect on potentially making the medication less effective but it may also inadvertently lead to taking doses too close together, thereby increasing the risks of side effects.

Click here to find out what to do if you forgot to take your medication

US brand name of orphenadrine and manufacturer

Orphenadrine is available in the US under the brand name Norflex. It is manufactured by various pharmaceutical companies.

UK brand name of orphenadrine and manufacturer

Orphenadrine citrate is not available in the UK, however orphenadrine hydrochloride is.

Prescription requirement for orphenadrine

Orphenadrine is a prescription medication and requires a prescription from a healthcare provider.

FDA approval of orphenadrine

Orphenadrine has received FDA approval for the treatment of muscle spasms and associated pain.

Is orphenadrine available in the UK on NHS?

Orphenadrine hydrochloride is available on the NHS in the UK to alleviate the extrapyramidal syndrome induced by drugs such as the phenothiazine derivatives.

Active ingredient of orphenadrine and mechanism of action

Orphenadrine contains the active ingredient orphenadrine citrate, which is a skeletal muscle relaxant. It works by blocking the action of certain chemicals in the brain that contribute to muscle spasms and pain.

Uses of orphenadrine

Orphenadrine has anticholinergic effects and is primarily used for the treatment of muscle spasms and associated pain. It is commonly prescribed for conditions such as muscle strains, sprains, and musculoskeletal injuries.

Dosage forms of orphenadrine

Orphenadrine is available in the form of extended release tablets. The specific dosage and strength will depend on the individual’s condition and the recommendation of their healthcare provider.

Dosage of orphenadrine

The dosage of orphenadrine will vary depending on the specific condition being treated. It is important to follow the medical advice provided by a healthcare professional.

Precautions and warnings for orphenadrine

  • Orphenadrine may cause drowsiness, dizziness, and blurred vision. It is important to avoid activities that require mental alertness, such as driving or operating machinery, until you know how the medication affects you
  • Orphenadrine should be used with caution in individuals with certain medical conditions, such as glaucoma, urinary retention, and heart conditions
  • Orphenadrine may interact with certain medications, including antidepressants, antihistamines, and central nervous system depressants. Inform your healthcare provider about all the medications you are taking
  • Orphenadrine should not be used in individuals with a known hypersensitivity to the drug or its components
  • Tell your doctor if you have myasthenia gravis, glaucoma, ulcers, an enlarged prostate, urinary tract or intestinal blockage, liver disease, kidney disease, or heart disease
  • It is not known if orphenadrine passes into breast milk. Speak to your doctor before breast-feeding

Side effects of orphenadrine

Common side effects of orphenadrine may include drowsiness, dizziness, lightheadedness, dry mouth, blurred vision, and constipation. Other more serious side effects include rapid heartbeat, difficulty urinating, and allergic reactions. If you experience any severe or concerning side effects, seek medical attention.

Interactions with other drugs

Orphenadrine may interact with other medications, including certain antidepressants, opioids (such as codeine, and hydrocodone), baclofen, methocarbamol, other muscle relaxants (such as cyclobenzaprine), antihistamines (such as diphenhydramine), and central nervous system depressants.

It is important to inform your healthcare provider about all the medications you are taking, including prescription drugs, over-the-counter (OTC) drugs, dietary supplements, multivitamins, and herbal products, to avoid any adverse effects and potential drug interactions.



Now Patient has taken all reasonable steps to ensure that all material is factually accurate, complete, and current. However, the knowledge and experience of a qualified healthcare professional should always be sought after instead of using the information in this page. Before taking any drug, you should always speak to your doctor or another qualified healthcare provider.

The information provided here about medications is subject to change and is not meant to include all uses, precautions, warnings, directions, drug interactions, allergic reactions, or negative effects. The absence of warnings or other information for a particular medication does not imply that the medication or medication combination is appropriate for all patients or for all possible purposes.

Stefano Mirabello Medical Reviewer
Pharmacist / B.Pharm
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