Used for Menopause and Cancer

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Manufactured by AbbVie Inc.

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Jamie Winn NowPatientGreen tick
Updated on 26 Apr 2024

ORIAHNN Uses, Side Effects, Interactions, Warnings & Dosing

What is ORIAHNN?

What is ORIAHNN?

ORIAHNN is the brand name for elagolix/estradiol/norethindrone acetate and elagolix oral capsules.

What dosages is ORIAHNN available in?

What dosages is ORIAHNN available in?

ORIAHNN is available as the following:

  • Morning (AM) capsule: elagolix 300 mg, estradiol 1 mg, norethindrone acetate 0.5 mg
  • Evening (PM) capsule: elagolix 300 mg
What is ORIAHNN used for?

What is ORIAHNN used for?

  • ORIAHNN is a Gonadotropin-releasing hormone (GnRH) antagonist/estrogen/progestin and is used to treat heavy menstrual bleeding associated with uterine fibroids in premenopausal women
How does ORIAHNN work?

How does ORIAHNN work?

ORIAHNN is a combination of three medications that help manage heavy menstrual bleeding associated with uterine fibroids: Elagolix is a gonadotropin-releasing hormone (GnRH) antagonist, meaning that it attaches to and blocks GnRH receptors (a protein that responds to signals) in your pituitary gland. With these receptors blocked, they don’t release hormones that worsen bleeding associated with uterine fibroids. Estradiol lowers the risk of bone loss (osteoporosis) caused by elagolix alone. Norethindrone works to protect the uterus from harmful side effects caused by estrogen (estradiol) alone, like uterine cancer.

How do I take ORIAHNN?

How do I take ORIAHNN?

  • ORIAHNN is typically taken as 1 capsule (elagolix 300 mg, estradiol 1 mg, norethindrone acetate 0.5 mg)
  • in the morning and 1 capsule (elagolix 300 mg) in the evening for up to 24 months
Is it safe for me to take ORIAHNN?

Is it safe for me to take ORIAHNN?

ORIAHNN is a safe and effective treatment when used for FDA licensed indications. However, like all medications, they may give you unwanted side effects. You should always discuss potential side effects with your physician to ensure the medication is suitable and right for you. You should not use this medication in any of the following:

  • High risk of arterial, venous thrombotic, or thromboembolic disorder
  • Pregnancy
    Known osteoporosis
  • Current or history of breast cancer or other hormonally-sensitive malignancies
  • Known liver impairment or disease
  • Undiagnosed abnormal uterine bleeding
  • Known hypersensitivity to ingredients of ORIAHNN
  • Organic anion transporting polypeptide (OATP)1B1 inhibitors that are known or expected to significantly increase elagolix plasma concentrations
ORIAHNN Common Side Effects

ORIAHNN Common Side Effects

Common side effects of ORIAHNN:

  • Hot flush Headache
  • Feeling low energy
  • Abnormal vaginal bleeding or spotting
ORIAHNN Serious Side Effects

ORIAHNN Serious Side Effects

Serious side effects are rare with ORIAHNN. Contact your healthcare provider immediately if you experience any of the following.

  • Liver damage: yellowing of your skin and whites of your eyes, stomach pain, nausea, vomiting, loss of appetite, dark urine, tiredness
  • Serious allergic reaction: rash, swelling of lips, tongue, or throat, difficulty breathing
Effects of other drugs, drug classes and over-the-counter products on ORIAHNN

Effects of other drugs, drug classes and over-the-counter products on ORIAHNN

  • The following medications may interact with ORIAHNN:
  • Increase monitoring of digoxin concentrations and potential signsand symptoms of clinical toxicity when initiating ORIAHNN in patients who are taking digoxin. If ORIAHNN is discontinued increase monitoring of digoxin concentrations
  • Consider increasing the dose of midazolam by no more than 2-fold and individualize midazolam therapy based on the patient’s response
  • Monitor lipid levels and adjust the dose of rosuvastatin, if necessary
  • No dose adjustment needed for omeprazole 40 mg once daily when co-administered with ORIAHNN. When ORIAHNN is used concomitantly with higher doses of omeprazole, consider dosage reduction of omeprazole
Who makes ORIAHNN?

Who makes ORIAHNN?

AbbVie Inc.

Is ORIAHNN safe in pregnancy?

Is ORIAHNN safe in pregnancy?

Exposure to ORIAHNN early in pregnancy may increase the risk of early pregnancy loss. Women should use non-hormonal contraception during treatment and for 28 days after discontinuing ORIAHNN. ORIAHNN may delay the ability to recognize the occurrence of a pregnancy because it alters menstrual bleeding. Perform pregnancy testing if pregnancy is suspected and discontinue ORIAHNN if pregnancy is confirmed.


What to do if you missed your ORIAHNN dose

The FDA's medical product safety reporting program for health professionals, patients and consumers.

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Medical Disclaimer

NowPatient has taken all reasonable steps to ensure that all material is factually accurate, complete, and current. However, the knowledge and experience of a qualified healthcare professional should always be sought after instead of using the information on this page. Before taking any drug, you should always speak to your doctor or another qualified healthcare provider.

The information provided here about medications is subject to change and is not meant to include all uses, precautions, warnings, directions, drug interactions, allergic reactions, or negative effects. The absence of warnings or other information for a particular medication does not imply that the medication or medication combination is appropriate for all patients or for all possible purposes.

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