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Medroxyprogesterone is available as a 2.5 mg, 5 mg, and 10 mg oral tablet.

Medroxyprogesterone is a progesterone that is used to treat the following:
Lack of menstrual periods due to hormone imbalance
Irregular periods due to hormone imbalance Protection of the uterus in postmenopausal women who are taking estrogen medications

Medroxyprogesterone is a progestin. It’s a lab-made version of the natural hormone progesterone. It regulates menstrual periods by helping to balance the levels of progesterone in the body.
When taken together with estrogen-containing medications, Medroxyprogesterone helps protect the uterus from the effects of estrogen in postmenopausal women. It helps control the growth of the uterine lining to lower the risk of endometrial cancer.

Medroxyprogesterone is typically taken as 5 mg or 10 mg by mouth once a day for 5 to 14 days.

Medroxyprogesterone is a safe and effective treatment when used for FDA licensed indications. However, like all medications, they may give you unwanted side effects. You should always discuss potential side effects with your physician to ensure the medication is suitable and right for you. Medroxyprogesterone should not be used in women with any of the following conditions:

• Undiagnosed abnormal genital bleeding
• Known, suspected, or history of cancer of the breast
• Known or suspected estrogen- or progesterone-dependent neoplasia
• Active deep vein thrombosis, pulmonary embolism or a history of these conditions
• Active or recent (within the past year) arterial thromboembolic disease (for example, stroke and myocardial infarction)
• Known liver dysfunction or disease
• Missed abortion
• As a diagnostic test for pregnancy
• Known hypersensitivity to the ingredients in Medroxyprogesterone tablets
• Known or suspected pregnancy.

Common side effects of Medroxyprogesterone:

• Spotting or breakthrough bleeding
• Heavier or lighter periods
• Breast tenderness
• Nausea
• Dizziness
• Headache

Serious side effects are rare with Medroxyprogesterone. Contact your healthcare provider immediately if you experience any of the following.

• Unusual or heavy vaginal bleeding
• When taken with estrogen medications:
• Heart attack: chest pain or tightness; pain that spreads along to your shoulder, arm, neck, or jaw
• Stroke: sudden trouble talking or walking; numbness on one side of your body or face; shortness of breath; sudden, severe headaches
• Deep vein thrombosis (blood clot in the leg): swelling, pain, muscle tightness, leg cramp
• Pulmonary embolism (blood clot in the lung): cough, chest pain, trouble breathing, racing heart
• Unusual changes to the breast: lumps, pain, swelling, changes in appearance

• No formal pharmacokinetic drug interaction studies have been conducted with Medroxyprogesterone

Various FDA-approved generic manufacturers

Medroxyprogesterone should not be used during pregnancy.

• Provera