lopinavir/ritonavir
Used for HIV
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Manufactured by various FDA-approved generic manufacturers.
*You can pay as little as $0 per fill using Drug Coupons or Patient Assistance Programs. Subject to applicability & eligibility requirements.
This content is intended for US audiences only
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lopinavir/ritonavir key facts
What dosages is lopinavir/ritonavir available in?
lopinavir/ritonavir is available in the following:
- Tablets: 200 mg lopinavir and 50 mg ritonavir
- Tablets: 100 mg lopinavir and 25 mg ritonavir
- Oral solution: 80 mg lopinavir and 20 mg ritonavir per milliliter
What is lopinavir/ritonavir used for?
lopinavir/ritonavir is a HIV ARV and is used to treat HIV infection (used with other antiretroviral medications).
How does lopinavir/ritonavir work?
lopinavir/ritonavir is a combination of two medications: lopinavir and ritonavir. They’re both protease inhibitors. They block a protein called protease from processing viral proteins that allow HIV to infect healthy cells. By blocking protease from working, lopinavir/ritonavir prevents HIV from making copies of itself and spreading. At low doses, such as in lopinavir/ritonavir, ritonavir helps slow the breakdown of lopinavir in the body. This “boosts” the levels of lopinavir in the body, which helps it work better and longer to fight the infection.
How do I take lopinavir/ritonavir?
Your dose can vary depending on your age, your health conditions, and your other medications (including other HIV medications). In general, lopinavir/ritonavir is taken by mouth either once daily or twice daily.
Adults
- Once-daily dosing: The typical dose is 800 mg/200 mg (lopinavir/ritonavir) by mouth once daily
- Twice-daily dosing: The typical dose is 400 mg/100 mg (lopinavir/ritonavir) by mouth twice daily
Children 2 weeks to 17 years of age
- Your child’s provider will determine their dose based on either their body weight or their body surface area (BSA). BSA is your child’s body size calculated based on weight and height
- lopinavir/ritonavir is typically taken by mouth twice daily. The maximum dose is 400 mg/100 mg (lopinavir/ritonavir) twice daily
Is it safe for me to take lopinavir/ritonavir?
lopinavir/ritonavir is a safe and effective treatment when used for FDA licensed indications. However, like all medications, they may give you unwanted side effects. You should always discuss potential side effects with your physician to ensure the medication is suitable and right for you. You should not use this medication in the following:
- Hypersensitivity to lopinavir/ritonavir (e.g., toxic epidermal necrolysis, StevensJohnson syndrome, erythema multiforme, urticaria, angioedema) or any of
its ingredients, including ritonavir - Co-administration with drugs highly dependent on CYP3A for clearance and for which elevated plasma levels may result in serious and/or lifethreatening events
Co-administration with potent CYP3A inducers where significantly reduced lopinavir plasma concentrations may be associated with the potential for loss of virologic response and possible resistance and cross resistance.
lopinavir/ritonavir Common Side Effects
Common side effects of lopinavir/ritonavir:
- Diarrhea
- Respiratory tract infection
- Nausea
- Feeling weak
- High cholesterol levels
- Vomiting
- Belly pain
- Muscle, joint, or back pain
- Headache or migraine
- Changes in taste
lopinavir/ritonavir Serious Side Effects
Serious side effects are rare with lopinavir/ritonavir. Contact your healthcare provider immediately if you experience any of the following.
- Severe allergic reactions: facial swelling, hives, rash, itchy skin, blistering or peeling of skin, body aches, trouble breathing
- Serious liver problems: nausea, vomiting, not feeling hungry, pain in the right side of the stomach, yellowing of the whites of the eyes or skin, dark-colored urine, light-colored stool
- Abnormal heart rhythm: chest pounding, trouble breathing, chest pain, feeling faint or lightheaded
Effects of other drugs, drug classes and over-the-counter products on lopinavir/ritonavir
The following medications may interact with lopinavir/ritonavir:
- Co-administration of lopinavir/ritonavir can alter the plasma concentrations of other drugs and other drugs may alter the plasma concentrations of lopinavir. The potential for drug-drug interactions must be considered prior to and during therapy
Who makes lopinavir/ritonavir?
Various FDA-approved generic manufacturers
Is lopinavir/ritonavir safe in pregnancy?
Once daily lopinavir/ritonavir dosing is not recommended in pregnancy. Avoid use of lopinavir/ritonavir oral solution during pregnancy due to the alcohol content. There is a pregnancy exposure registry that monitors pregnancy outcomes in women exposed to lopinavir/ritonavir during pregnancy. Physicians are encouraged to register patients by calling the Antiretroviral Pregnancy Registry at 1-800-258-4263.
The FDA's medical product safety reporting program for health professionals, patients and consumers.
Learn more about reporting side effectsDrug Savings Guide
A practical guide to saving money and receiving support with prescription costs
How can NowPatient help me to lower the cost of my lopinavir/ritonavir prescription?
After you create a FREE account with NowPatient, you will have access to 4 programs that can help lower the cost of your lopinavir/ritonavir prescription
Applicability to each program will be dependent on your insurance status.
How do the NowPatient lopinavir/ritonavir savings programs work?
After you have created your FREE account with NowPatient, you can access the various programs from your account dashboard. Each program has clear instructions on how to check your eligibility. You can see how the process works by clicking on the feature link below and seeing the ‘How it works’ steps.
Drug Coupon and Patient Assistance Programs require an eligibility quiz to be completed.
Are the NowPatient lopinavir/ritonavir savings programs suitable for everyone, regardless of insurance status?
No. Each program has its own eligibility and applicability requirements. The table below shows if a program is available to you, based on your insurance status.
| Rx Advantage Card* for lopinavir/ritonavir | Canadian Prescription Savings* for lopinavir/ritonavir | lopinavir/ritonavir Drug Coupon* | lopinavir/ritonavir Patient Assistance Program* | |
| Insured (federal, state or government) | Available | Available | Not Available | Available If Offered by Pharmaceutical Company |
| Insured (Commercial or Private) | Available | Available | Available If Offered by Pharmaceutical Company | Available If Offered by Pharmaceutical Company |
| Uninsured | Available | Available | Not Available | Available If Offered by Pharmaceutical Company |
| Insured but without pharmacy benefit or drug coverage | Available | Available | Not Available | Available If Offered by Pharmaceutical Company |
*This is not insurance.
Are the NowPatient drug savings programs suitable for brand and generic versions of lopinavir/ritonavir?
No. Each program has applicability requirements. Please see below
| Rx Advantage Card* for lopinavir/ritonavir | Canadian Prescription Savings* for lopinavir/ritonavir | lopinavir/ritonavir Drug Coupon* | lopinavir/ritonavir Patient Assistance Program* | |
| Brand | Yes | Yes | Yes, If Offered by Pharmaceutical Company | Yes, If Offered by Pharmaceutical Company |
| Generic | Yes | Yes | No | No |
*This is not insurance.
If you have Medicare Part D or Medicare Advantage and none of the lopinavir/ritonavir savings options are applicable or affordable for me, what can you do?
If you are insured with Medicare and the lopinavir/ritonavir drug savings options are not applicable to you and still remain unaffordable, then you can check Medicaid eligibility in your state by following the instructions at HealthCare.gov.
The government site is easy to use and after you have selected your state, it will navigate you to the appropriate contact point to make the application. State Medicaid programs may cover the full cost of your medication.
People who qualify for both Medicare and Medicaid are called ‘dual eligibles’.
If you are denied Medicaid for lopinavir/ritonavir, and you are still unable to afford your copay or co-insurance element (for example if you are in the coverage gap or Donut Hole) then you may be eligible for a federal support program like Low Income Subsidy. To be eligible for Low Income Subsidy, you need to be a resident in one of the 50 States or the District of Columbia. You can check eligibility online at SSA Medicare D Extra Help. You can also call Social Security at 1-800-772-1213 (TTY 1-800-325-0778).
I am uninsured or underinsured and none of the lopinavir/ritonavir prescription saving options are applicable or affordable for me, what can I do?
If you are uninsured or underinsured (for example, lopinavir/ritonavir is not covered by your plan) and the drug savings options are not applicable or still unaffordable, then you can check Medicaid eligibility in your state by following the instructions at HealthCare.gov.
The government site is easy to use and you can select your state and it will navigate you to the appropriate contact point to make the application. State Medicaid programs may cover the full cost of your medication.
If you are denied and all else fails, and if you have been prescribed lopinavir/ritonavir for an FDA-approved indication, you can call the pharmaceutical company to see if they have any other assistance programs.
I am commercially or privately insured and none of the lopinavir/ritonavir prescription saving options are applicable or affordable for me, what can I do?
If your medication is not covered by your plan, you can appeal your insurance company’s decision. Sometimes, a formal appeal can result in the drug being covered if it is deemed medically necessary.
If you cannot afford your copay contribution, then you can check Medicaid eligibility in your state by following the instructions at HealthCare.gov.
However, being privately insured might complicate your eligibility for Medicaid, as having private insurance may be considered in the financial eligibility assessment.
The government site is easy to use and you can select your state and it will navigate you to the appropriate contact point to make the application. If you qualify, state Medicaid may cover the full cost of your medication.
If I have federal, state or commercial insurance and none of the lopinavir/ritonavir prescription saving options are applicable or affordable for me, are there any other support organisations that can help me with my co-insurance or copay contributions?
If you have already tried Medicaid and received a denial letter or if you are insured with Medicare and have been denied Low-Income Subsidy, then you can try one of the following organizational support programs:
1. Patient Access Network Foundation (PAN) assistance for lopinavir/ritonavir
If you are having trouble paying for your lopinavir/ritonavir medication due to unaffordable copays or deductibles, the Patient Access Network Foundation (PAN), may be able to assist you. To qualify for PAN assistance for lopinavir/ritonavir you will need to meet one or all of the following criteria:
- Your income is below 400% of the federal poverty level
- lopinavir/ritonavir is prescribed for an approved FDA indication
- You live in and receive treatment in the United States or U.S. territories, even if you do not have U.S. citizenship
- You have Medicare insurance coverage that covers lopinavir/ritonavir
- If lopinavir/ritonavir is listed on PAN’s list of covered medications
You can check the Patient Access Network Foundation Website for more information.
2. HealthWell Foundation Copay Program for lopinavir/ritonavir
If you are having trouble paying for your lopinavir/ritonavir medication due to unaffordable copays or deductibles, the HealthWell Foundation Copay Program may be able to assist you. To qualify for assistance for lopinavir/ritonavir you will need to meet the following criteria:
- You live in and are being treated in the United States
- You are insured and your plan covers lopinavir/ritonavir
- If lopinavir/ritonavir is listed on the HealthWell Foundation’s list of covered medications
You can check the HealthWell Foundation Website for more information.
3. Patient Advocate Foundation Co-Pay Relief Program for lopinavir/ritonavir
Patient Advocate Foundation’s Co-Pay Relief program exists to help reduce the financial distress you or your family may face when paying for your lopinavir/ritonavir treatment. If you qualify and can demonstrate the need, the foundation will provide you with direct payment covering co-pays, co-insurance, and deductibles. To qualify for assistance for lopinavir/ritonavir you will need to meet the following criteria:
- You must be currently insured and have coverage for lopinavir/ritonavir
- You must have a confirmed diagnosis and treatment plan
- You must reside and receive treatment in the United States
- Your Income must fall at or below 300% or 400% of the Federal Poverty Guideline (FPG) with consideration for the Cost of Living Index (COLI) and number in the household
- Applications can also be completed by contacting the program sponsor, toll-free at 866-512-3861.
You can check the Patient Advocate Foundation Website for more information.
Medical Disclaimer
NowPatient has taken all reasonable steps to ensure that all material is factually accurate, complete, and current. However, the knowledge and experience of a qualified healthcare professional should always be sought after instead of using the information on this page. Before taking any drug, you should always speak to your doctor or another qualified healthcare provider.
The information provided here about medications is subject to change and is not meant to include all uses, precautions, warnings, directions, drug interactions, allergic reactions, or negative effects. The absence of warnings or other information for a particular medication does not imply that the medication or medication combination is appropriate for all patients or for all possible purposes.
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You can lower the cost of your prescription medications using our various savings programs which include drug coupons, savings card and manufacturer-sponsored patient assistance programs.
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