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Updated on 24 Apr 2024

lopinavir/ritonavir Uses, Side Effects, Interactions, Warnings & Dosing

What dosages is lopinavir/ritonavir available in?

What dosages is lopinavir/ritonavir available in?

lopinavir/ritonavir is available in the following:

  • Tablets: 200 mg lopinavir and 50 mg ritonavir
  • Tablets: 100 mg lopinavir and 25 mg ritonavir
  • Oral solution: 80 mg lopinavir and 20 mg ritonavir per milliliter
What is lopinavir/ritonavir used for?

What is lopinavir/ritonavir used for?

lopinavir/ritonavir is a HIV ARV and is used to treat HIV infection (used with other antiretroviral medications).

How does lopinavir/ritonavir work?

How does lopinavir/ritonavir work?

lopinavir/ritonavir is a combination of two medications: lopinavir and ritonavir. They’re both protease inhibitors. They block a protein called protease from processing viral proteins that allow HIV to infect healthy cells. By blocking protease from working, lopinavir/ritonavir prevents HIV from making copies of itself and spreading. At low doses, such as in lopinavir/ritonavir, ritonavir helps slow the breakdown of lopinavir in the body. This “boosts” the levels of lopinavir in the body, which helps it work better and longer to fight the infection.

How do I take lopinavir/ritonavir?

How do I take lopinavir/ritonavir?

Your dose can vary depending on your age, your health conditions, and your other medications (including other HIV medications). In general, lopinavir/ritonavir is taken by mouth either once daily or twice daily.


  • Once-daily dosing: The typical dose is 800 mg/200 mg (lopinavir/ritonavir) by mouth once daily
  • Twice-daily dosing: The typical dose is 400 mg/100 mg (lopinavir/ritonavir) by mouth twice daily

Children 2 weeks to 17 years of age

  • Your child’s provider will determine their dose based on either their body weight or their body surface area (BSA). BSA is your child’s body size calculated based on weight and height
  • lopinavir/ritonavir is typically taken by mouth twice daily. The maximum dose is 400 mg/100 mg (lopinavir/ritonavir) twice daily
Is it safe for me to take lopinavir/ritonavir?

Is it safe for me to take lopinavir/ritonavir?

lopinavir/ritonavir is a safe and effective treatment when used for FDA licensed indications. However, like all medications, they may give you unwanted side effects. You should always discuss potential side effects with your physician to ensure the medication is suitable and right for you. You should not use this medication in the following:

  • Hypersensitivity to lopinavir/ritonavir (e.g., toxic epidermal necrolysis, StevensJohnson syndrome, erythema multiforme, urticaria, angioedema) or any of
    its ingredients, including ritonavir
  • Co-administration with drugs highly dependent on CYP3A for clearance and for which elevated plasma levels may result in serious and/or lifethreatening events
    Co-administration with potent CYP3A inducers where significantly reduced lopinavir plasma concentrations may be associated with the potential for loss of virologic response and possible resistance and cross resistance.
lopinavir/ritonavir Common Side Effects

lopinavir/ritonavir Common Side Effects

Common side effects of lopinavir/ritonavir:

  • Diarrhea
  • Respiratory tract infection
  • Nausea
  • Feeling weak
  • High cholesterol levels
  • Vomiting
  • Belly pain
  • Muscle, joint, or back pain
  • Headache or migraine
  • Changes in taste
lopinavir/ritonavir Serious Side Effects

lopinavir/ritonavir Serious Side Effects

Serious side effects are rare with lopinavir/ritonavir. Contact your healthcare provider immediately if you experience any of the following.

  • Severe allergic reactions: facial swelling, hives, rash, itchy skin, blistering or peeling of skin, body aches, trouble breathing
  • Serious liver problems: nausea, vomiting, not feeling hungry, pain in the right side of the stomach, yellowing of the whites of the eyes or skin, dark-colored urine, light-colored stool
  • Abnormal heart rhythm: chest pounding, trouble breathing, chest pain, feeling faint or lightheaded
Effects of other drugs, drug classes and over-the-counter products on lopinavir/ritonavir

Effects of other drugs, drug classes and over-the-counter products on lopinavir/ritonavir

The following medications may interact with lopinavir/ritonavir:

  • Co-administration of lopinavir/ritonavir can alter the plasma concentrations of other drugs and other drugs may alter the plasma concentrations of lopinavir. The potential for drug-drug interactions must be considered prior to and during therapy
Who makes lopinavir/ritonavir?

Who makes lopinavir/ritonavir?

Various FDA-approved generic manufacturers

Is lopinavir/ritonavir safe in pregnancy?

Is lopinavir/ritonavir safe in pregnancy?

Once daily lopinavir/ritonavir dosing is not recommended in pregnancy. Avoid use of lopinavir/ritonavir oral solution during pregnancy due to the alcohol content. There is a pregnancy exposure registry that monitors pregnancy outcomes in women exposed to lopinavir/ritonavir during pregnancy. Physicians are encouraged to register patients by calling the Antiretroviral Pregnancy Registry at 1-800-258-4263.


What to do if you missed your lopinavir/ritonavir dose

The FDA's medical product safety reporting program for health professionals, patients and consumers.

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NowPatient has taken all reasonable steps to ensure that all material is factually accurate, complete, and current. However, the knowledge and experience of a qualified healthcare professional should always be sought after instead of using the information on this page. Before taking any drug, you should always speak to your doctor or another qualified healthcare provider.

The information provided here about medications is subject to change and is not meant to include all uses, precautions, warnings, directions, drug interactions, allergic reactions, or negative effects. The absence of warnings or other information for a particular medication does not imply that the medication or medication combination is appropriate for all patients or for all possible purposes.

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