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Linagliptin/Empagliflozin is available as an oral tablet that contains 10 mg empagliflozin/5 mg linagliptin or 25 mg empagliflozin/5 mg linagliptin.

Linagliptin/Empagliflozin is a SGLT2 inhibitor / DPP-4 inhibitor and is used for the following:

• Type 2 diabetes in adults
• Lower the chance of death due to heart problems for adults with Type 2 diabetes and heart disease

Linagliptin/Empagliflozin is a combination of two medications. Empagliflozin is a sodium-glucose cotransporter 2 (SGLT2) inhibitor. It works in the kidneys to prevent the absorption of sugar back into your body. It lowers blood sugar by causing your body to get rid of excess sugar through your urine. Linagliptin is a dipeptidyl peptidase-4 (DPP-4) inhibitor. It works by blocking DPP-4, a protein that breaks down certain hormones that normally tell your body to make more insulin and produce less sugar. When DPP-4 causes low levels of these hormones, you end up having high blood sugar levels. By blocking the action of DPP-4, linagliptin allows your body to produce more insulin and make less sugar. In doing so, linagliptin helps lower your blood sugar levels.

• Linagliptin/Empagliflozin is typically dosed at 10 mg/5 mg (empagliflozin/linagliptin) by mouth once daily in the morning. The maximum dose is 25 mg/5 mg (empagliflozin/linagliptin) once daily in the morning

Linagliptin/Empagliflozin is a safe and effective treatment when used for FDA licensed indications. However, like all medications, they may give you unwanted side effects. You should always discuss potential side effects with your physician to ensure the medication is suitable and right for you. You should not use this medication if you are on dialysis or have a hypersensitivity to empagliflozin, linagliptin, or any of the excipients in Linagliptin/Empagliflozin.

Common side effects of Linagliptin/Empagliflozin:

• Urinary tract infections
• Upper respiratory tract infection or common cold symptoms

Serious side effects are rare with Linagliptin/Empagliflozin. Contact your healthcare provider immediately if you experience any of the following.

• Inflamed pancreas: upper stomach pain, fever, nausea, vomiting
• Ketoacidosis (too much blood acid): shortness of breath, vomiting, belly pain, dry skin and mouth, feeling very tired, fruity-smelling breath
• Sudden kidney problems: urinating less than usual, chest pain
• Low blood pressure: dizziness, lightheadedness, confusion
• Serious genital infection: pain, swelling, or redness in the genital area, fever, weakness
• Severe skin or allergic reactions: rash, blisters, sores, trouble breathing, swelling

The following medications may interact with Linagliptin/Empagliflozin:

• See full prescribing information for information on drug interactions and
• interference of Linagliptin/Empagliflozin with laboratory tests.

Various FDA-approved generic manufacturers

Based on animal data showing adverse renal effects from empagliflozin, Linagliptin/Empagliflozin is not recommended
during the second and third trimesters of pregnancy.

• Glyxambi