leflunomide
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Manufactured by various FDA-approved generic manufacturers.
*You can pay as little as $0 per fill using Drug Coupons or Patient Assistance Programs. Subject to applicability & eligibility requirements.
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Useful information about leflunomide
What dosages is leflunomide available in?
leflunomide is available as a 10 mg, 20 mg, and 100 mg oral tablet.
What is leflunomide used for?
leflunomide is a non-biologic, disease-modifying antirheumatic drug (DMARD) that is used to treat adults with active rheumatoid arthritis.
How does leflunomide work?
leflunomide is a pyrimidine synthesis inhibitor. It blocks certain proteins and cells of the immune system that are overactive from turning on. This lowers inflammation in the joints, which helps treat symptoms and prevent joint damage in people with rheumatoid arthritis.
How do I take leflunomide?
leflunomide is typically taken as a : 100 mg dose by mouth daily for 3 days and then 20 mg daily thereafter.
Is it safe for me to take leflunomide?
leflunomide is a safe and effective treatment when used for FDA licensed indications. However, like all medications, they may give you unwanted side effects. You should always discuss potential side effects with your physician to ensure the medication is suitable and right for you. You should not take this medication if you are pregnant, have severe hepatic impairment, or are currently taking teriflunomide.
leflunomide Common Side Effects
Common side effects of leflunomide include:
- Diarrhea
- Headache
- Nausea
- Rash
- Abnormal liver labs
- Hair thinning or hair loss
- High blood pressure
leflunomide Serious Side Effects
Serious side effects are rare with leflunomide. Contact your healthcare provider immediately if you experience any of the following.
- Liver problems: nausea, vomiting, stomach pain, swelling of your stomach, yellowing of your skin or the whites of your eyes, clay-colored stool, confusion
- Serious infections: fever, difficulty breathing, weakness, cough, sweating, chills, stomach pain, diarrhea, burning when you urinate, urinating more often
- Serious allergic reactions and skin reactions: sore throat, fever, fatigue, rash, hives, painful blisters, skin reddening, skin peeling, swollen lymph nodes
Effects of other drugs, drug classes and over-the-counter products on leflunomide
The following medications may interact with leflunomide:
- Drugs metabolized by CYP2C8 and OAT3 transporters – May increase the levels of these drugs
- Oral contraceptives – May increase levels of ethinylestradiol and levonorgestrel
- Drugs metabolized by CYP1A2 – May decrease the levels of these drugs.
- Warfarin: Monitor INR as INR may be decreased
- Drugs metabolized by BCRP and OATP1B1/B3 transporters: May increase levels of these drugs
- Rosuvastatin: The dose of rosuvastatin should not exceed 10 mg once daily in patients taking
- leflunomide
Who makes leflunomide?
Various FDA-approved generic manufacturers
Is leflunomide safe in pregnancy?
leflunomide may cause harm to your unborn baby. You should take a pregnancy test before starting this medication. Use effective contraception if you can become pregnant during treatment and during a drug elimination procedure. Stop leflunomide and use an accelerated drug elimination procedure if you become pregnant.
The FDA's medical product safety reporting program for health professionals, patients and consumers.
Learn more about reporting side effects
Drug Savings Tips
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Medical Disclaimer
NowPatient has taken all reasonable steps to ensure that all material is factually accurate, complete, and current. However, the knowledge and experience of a qualified healthcare professional should always be sought after instead of using the information on this page. Before taking any drug, you should always speak to your doctor or another qualified healthcare provider.
The information provided here about medications is subject to change and is not meant to include all uses, precautions, warnings, directions, drug interactions, allergic reactions, or negative effects. The absence of warnings or other information for a particular medication does not imply that the medication or medication combination is appropriate for all patients or for all possible purposes.
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