LeflunomidePrices, Coupons & Savings

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*Based on the difference between the U&C price submitted and the price the patient paid, as of April 2023.

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  2. Leflunomide
    Generic for Arava
    30 tablets $24.3 USD
    Save $200.40
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Do you need a prescription for leflunomide?

Yes, leflunomide is only available with a valid physician Rx.

How much is leflunomide without Insurance in the US?

Our website gives two competitive savings options to US customers who wish to purchase leflunomide, as either a brand or generic, if available. The first is access to medications through our mail-order online pharmacy. The second is by using the Now Patient Rx Advantage Card, which can be used in over 65,000 pharmacies nationwide, across America. If you are insured, then in most cases, the cash price will be significantly cheaper than the copay.

What will my out-of-pocket cost be for leflunomide in the US?

There are no out-of-pocket (OOP) costs because we are currently only offering a cash-based option to purchase medications.

Is Now Patient a leflunomide savings card?

Yes. Save up to 90% on your leflunomide with the FREE Now Patient Rx Advantage card*.
*Based on the difference between the U&C submitted by the pharmacy and the price the patients pay.

Can you handle Rx transfers for home delivery in the US?

Yes. If you use the mail-order online pharmacy option, then we can handle requests by you to have your prescription transferred to our pharmacy for home delivery. We can even help you manage your refills by giving you timely reminders, so you do not run out of your medication.

Is Now Patient a leflunomide coupon provider in the US?

No. Now Patient does not provide leflunomide coupons or FREE leflunomide samples.

Do you accept commercial, Medicare or Medicaid coverage for leflunomide in the US?

No. Currently, we only offer cash-based options for purchase, therefore we do not require your insurance benefit details. In the future, our plan is to be able to handle commercial insurance, Medicare and Medicaid including cases where you have multiple health plans that provide benefit coverage (e.g. Medicaid and Commercial). We also anticipate being able to handle more complex scenarios such as using primary insurance combined with a manufacturer copay assistance program.

Does Now Patient work with Medicare?

Our cash-based prices for medications are typically cheaper than Medicare copays. We do not bill Medicare Part D (standalone drug coverage) or Medicare Advantage (combined health and drug coverage). When you purchase your medication from Now Patient, you will be doing so out of your pocket. The spend will not count towards your plan deductibles or gaps.

Does Now Patient work with Commercial Insurance?

Our cash-based prices for medications are typically cheaper than commercial plan copays. We do not bill your commercial plan. When you purchase your medication from Now Patient, you will be doing so out of your pocket. The spend will not count towards your plan deductibles or gaps.

What should you do if you use too much leflunomide?


Call your doctor right away or seek immediate medical attention if your symptoms do not improve or they become worse after using leflunomide. You can also call 800-222-1222 to reach the American Association of Poison Control Centers or use its online resource if you think you’ve used too much leflunomide. But if you have severe symptoms, call 911 (or your local emergency number) immediately or go to the nearest emergency room.


If you think it is an emergency, call 999 or find your nearest A&E
If you need help now, but it’s not an emergency go to 111.nhs.uk or call 111. Alternatively you can speak to one of our pharmacists or use the Now Patient app to make an appointment with your GP.

What should I do if I miss my dose?

There are occasions when people forget to take their medication at correct prescribed times. This may not only have an effect on potentially making the medication less effective but it may also inadvertently lead to taking doses too close together, thereby increasing the risks of side effects.

Click here to find out what to do if you forgot to take your medication

What is generic leflunomide?

Generic leflunomide refers to the non-brand-name version of the medication. It contains the same active ingredient as the brand-name drug but is typically less expensive.

FDA approval of leflunomide

Leflunomide is approved by the U.S. Food and Drug Administration (FDA) for the treatment of rheumatoid arthritis.

Active ingredient of leflunomide

The active ingredient of leflunomide is leflunomide.

US brand name of leflunomide and manufacturer

Leflunomide is available in the US under the brand name Arava. It is manufactured by Sanofi-Aventis U.S. LLC.

UK brand name of leflunomide and manufacturer

In the UK, leflunomide is available under the brand name Arava. The manufacturer may vary depending on the brand name.

Prescription requirement for leflunomide

A prescription (Rx) is required for leflunomide in both the US and the UK.

Availability of leflunomide in the UK with NHS prescription

Leflunomide is available in the UK with an NHS prescription.

Conditions treated by leflunomide

Leflunomide is primarily used for the treatment of rheumatoid arthritis, a chronic autoimmune disease that causes inflammation and joint pain, and psoriatic arthritis. Leflunomide is a pyrimidine synthesis inhibitor that works by blocking the action of dihydroorotate dehydrogenase.

How does leflunomide work?

Leflunomide is classed as a disease-modifying antirheumatic drug (DMARD). The exact mechanism of action of leflunomide in treating active rheumatoid arthritis is not fully understood. It is believed to suppress the immune system, reduce inflammation, and slow down the progression of joint damage.

Forms of leflunomide available

Leflunomide is available in the form of oral tablets. Leflunomide should be stored at room temperature away from moisture and light, and away from children and pets.

Dosage of leflunomide

Leflunomide is normally taken as a 10 mg or 20 mg tablet once daily. However, your dose of leflunomide may vary depending on the specific condition being treated, disease activity, and individual patient factors. It is important to follow the medical advice provided by the healthcare provider.

Directions for leflunomide use

Leflunomide should be taken exactly as directed by the healthcare provider. The medication is usually taken once daily with or without food. It may take several weeks or months of continuous use to experience the full benefits of leflunomide.

Warnings and precautions for leflunomide

  • Leflunomide increases the levels of certain liver enzymes and can potentially cause liver problems, including liver damage. You should not use leflunomide if you have liver disease, such as hepatitis or cirrhosis. Regular liver function tests are necessary during treatment
  • It may interact with certain medications, including other immunosuppressants, anticoagulants such as warfarin, cholestyramine, and drugs that affect the liver. Inform a healthcare professional about all medications, vitamins, supplements, and herbal treatments being taken
  • Do not take leflunomide if you are already taking teriflunomide, or if you have had an allergic reaction to teriflunomide in the past

Use of leflunomide during pregnancy

Leflunomide is contraindicated during pregnancy due to the potential risk of harm to the developing fetus. Adequate birth control should be used by both males and females during and after treatment with leflunomide.

Use of leflunomide while breastfeeding

Leflunomide should not be used while breastfeeding due to the potential risk to the infant. It is recommended to discontinue breastfeeding or discontinue leflunomide, taking into account the importance of the medication to the mother.

Possible side effects of leflunomide

In clinical trials common side effects of leflunomide included diarrhea, nausea, abdominal pain, weight loss, back pain, increased blood pressure, hair loss, headache, and rash. Serious side effects included liver problems, severe allergic reactions, lung problems such as chest pain, shortness of breath and cough, unusual tiredness, and blood disorders. You should report any adverse effects to a healthcare provider when taking this medication.

Similar drugs to leflunomide

Other medications used for the treatment of rheumatoid arthritis include methotrexate, sulfasalazine, and biologic therapies.



Now Patient has taken all reasonable steps to ensure that all material is factually accurate, complete, and current. However, the knowledge and experience of a qualified healthcare professional should always be sought after instead of using the information in this page. Before taking any drug, you should always speak to your doctor or another qualified healthcare provider.

The information provided here about medications is subject to change and is not meant to include all uses, precautions, warnings, directions, drug interactions, allergic reactions, or negative effects. The absence of warnings or other information for a particular medication does not imply that the medication or medication combination is appropriate for all patients or for all possible purposes.

About Now Patient

Now Patient’s online services are available in the US and UK. We help you manage your prescriptions, doctor appointments, test results, health risks, and a lot more, all in one place for FREE. If you are in the United States, you could enjoy savings using Now Patient’s mail-order pharmacy or use the Now Patient Rx Advantage Card at over 65,000 pharmacies, with savings of up to 90% on popular FDA-approved brand and generic medications like Ozempic, Mounjaro, clopidogrel and lots more. We do not currently handle commercial insurance, Medicare or Medicaid. UK NHS and private prescriptions are delivered FREE of charge across England & Wales by our UK NHS online pharmacy.

Stefano Mirabello Medical Reviewer
Pharmacist / B.Pharm
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