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Arava is the brand name for leflunomide and is availabe as an oral tablet.

Arava is available as a 10 mg, 20 mg, and 100 mg oral tablet.

Arava is a non-biologic, disease-modifying antirheumatic drug (DMARD) that is used to treat adults with active rheumatoid arthritis.

Arava is a pyrimidine synthesis inhibitor. It blocks certain proteins and cells of the immune system that are overactive from turning on. This lowers inflammation in the joints, which helps treat symptoms and prevent joint damage in people with rheumatoid arthritis.

Arava is typically taken as a : 100 mg dose by mouth daily for 3 days and then 20 mg daily thereafter.

Arava is a safe and effective treatment when used for FDA licensed indications. However, like all medications, they may give you unwanted side effects. You should always discuss potential side effects with your physician to ensure the medication is suitable and right for you. You should not take this medication if you are pregnant, have severe hepatic impairment, or are currently taking teriflunomide.

Common side effects of Arava include:

• Diarrhea
• Headache
• Nausea
• Rash
• Abnormal liver labs
• Hair thinning or hair loss
• High blood pressure

Serious side effects are rare with Arava. Contact your healthcare provider immediately if you experience any of the following.

• Liver problems: nausea, vomiting, stomach pain, swelling of your stomach, yellowing of your skin or the whites of your eyes, clay-colored stool, confusion
• Serious infections: fever, difficulty breathing, weakness, cough, sweating, chills, stomach pain, diarrhea, burning when you urinate, urinating more often
• Serious allergic reactions and skin reactions: sore throat, fever, fatigue, rash, hives, painful blisters, skin reddening, skin peeling, swollen lymph nodes

The following medications may interact with Arava:

• Drugs metabolized by CYP2C8 and OAT3 transporters – May increase the levels of these drugs
• Oral contraceptives – May increase levels of ethinylestradiol and levonorgestrel
• Drugs metabolized by CYP1A2 – May decrease the levels of these drugs.
• Warfarin: Monitor INR as INR may be decreased
• Drugs metabolized by BCRP and OATP1B1/B3 transporters: May increase levels of these drugs
• Rosuvastatin: The dose of rosuvastatin should not exceed 10 mg once daily in patients taking
• Arava

Sanofi

Arava may cause harm to your unborn baby. You should take a pregnancy test before starting this medication. Use effective contraception if you can become pregnant during treatment and during a drug elimination procedure. Stop Arava and use an accelerated drug elimination procedure if you become pregnant.

• Leflunomide