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Lamictal XR is the brand name for lamotrigine and is available as an extended-release oral tablet.

Lamictal XR is available as a 25 mg, 50 mg, 100 mg, 200 mg, 250 mg, and 300 mg extended-release oral tablet.

Lamictal XR is an antiepileptic that is used to treat primary generalized tonic-clonic (PGTC) seizures and partial onset seizures with or without secondary generalization in
patients ≥13 years of age.

Lamictal XR is an antiepileptic. It’s not exactly clear how this medication works to manage seizures and treat bipolar disorder.
For seizures, research suggests that lamotrigine (Lamictal) can block and prevent your brain from sending certain chemicals or signals that can overly excite your nerves. This helps lower bursts of activity in your brain, which can prevent seizures.

Lamictal XR is typically started at a low dose, and the dose will be raised in the following weeks. The dose depends on what you’re taking lamotrigine (Lamictal) for, your age, and the other medications that you’re taking. Your dose might also differ if you have kidney or liver problems. The typical maintenance dose ranges from 200 mg to 600 mg once daily.

Lamictal XR is a safe and effective treatment when used for FDA licensed indications. However, like all medications, they may give you unwanted side effects. You should always discuss potential side effects with your physician to ensure the medication is suitable and right for you. You should not use this medication if you have a known hypersensitivity to the drug or its ingredients.

Common side effects of Lamictal XR:

• Dizziness
• Nausea
• Vomiting
• Tremor
• Feeling tired
• Double vision
• Diarrhea

Serious side effects are rare with Lamictal XR. Contact your healthcare provider immediately if you experience any of the following.

• Severe allergic or skin reaction: rash, blistering or peeling of skin, hives, painful sores in your mouth or around your eyes, fever, trouble breathing, swollen lymph nodes
• Overactive immune system: fever, rash, belly pain or swelling, brown urine, yellowing of the whites of the eyes or skin
• Irregular heartbeat
• Suicidal thoughts and behavior
• Meningitis (brain inflammation): stiff neck, rash, fever, light sensitivity, headache, chills, nausea, vomiting

The following medications may interact with Lamictal XR:

• Valproate increases lamotrigine concentrations more than 2-fold
• Carbamazepine, phenytoin, phenobarbital, primidone, and rifampin decrease lamotrigine concentrations by approximately 40%
• Estrogen-containing oral contraceptives decrease lamotrigine concentrations by approximately 50%.
• Protease inhibitors lopinavir/ritonavir and atazanavir/lopinavir decrease lamotrigine exposure by approximately 50% and 32%, respectively
• Coadministration with organic cationic transporter 2 substrates with narrow therapeutic index is not recommended

GlaxoSmithKline

Lamictal XR may cause harm to your unborn baby based on animal studies. You should talk to your healthcare provider before taking this medication if you are pregnant. There is a pregnancy exposure registry that monitors pregnancy outcomes in women exposed to AEDs, including Lamictal XR, during pregnancy. Encourage women who are taking Lamictal XR during pregnancy to enroll in the North American Antiepileptic Drug (NAAED) Pregnancy Registry by calling 1-888-233-2334 or visiting AED pregnancy registry 

• Lamotrigine