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Irbesartan/Hydrochlorothiazide is available as an oral tablet that contains 150 mg irbesartan/12.5 mg hydrochlorothiazide or 300 mg irbesartan/12.5 mg hydrochlorothiazide.

Irbesartan/Hydrochlorothiazide is a combination medication that’s used to treat high blood pressure.

Irbesartan/Hydrochlorothiazide is a combination of irbesartan and hydrochlorothiazide. Irbesartan is an angiotensin II receptor blocker (ARB), which blocks a chemical that tightens your blood vessels. This causes your blood vessels to relax and allows more blood and oxygen to reach the heart and other parts of your body.
Hydrochlorothiazide is a thiazide diuretic (water pill) that makes you urinate more. It lowers blood pressure by working in your kidneys to get rid of extra water and electrolytes, like sodium, chloride, and potassium.

Irbesartan/Hydrochlorothiazide is typically taken by mouth once daily.

Irbesartan/Hydrochlorothiazide is a safe and effective treatment when used for FDA licensed indications. However, like all medications, they may give you unwanted side effects. You should always discuss potential side effects with your physician to ensure the medication is suitable and right for you. You should not take this medication if you have anuria (you aren’t producing urine) or a hypersensitivity to sulfonamide-derived drugs. You should also not take aliskiren along with Irbesartan/Hydrochlorothiazide if you have diabetes.

Common side effects of Irbesartan/Hydrochlorothiazide include:

• Dizziness
• Tiredness
• Muscle pain

Serious side effects are rare with Irbesartan/Hydrochlorothiazide. Contact your healthcare provider immediately if you experience any of the following.

• Kidney problems: Difficulties urinating, swelling in your legs or feet, tiredness, confusion, nausea
• Electrolyte imbalance: Dry mouth, weakness, tiredness, dizziness, muscle pain or cramps, irregular heart beat, vomiting, or nausea
• Allergic reaction: Rash, hives, difficulty breathing, difficulty swallowing, or swelling of the face, lips, or throat

The following medications may interact with Irbesartan/Hydrochlorothiazide:

• NSAIDs and selective COX-2 inhibitors – Can reduce diuretic, natriuretic of diuretic and may lead to increased risk of kidney impairment and reduced antihypertensive effect
• Antidiabetic drugs – Dosage adjustment of antidiabetic may be required.
• Cholestyramine and colestipol – Reduced absorption of thiazides
• Lithium – Increases in serum lithium concentrations and lithium toxicity
• Carbamazepine – Increased risk of hyponatremia

Various FDA-approved generic manufacturers

Irbesartan/Hydrochlorothiazide may cause harm to your unborn baby and should be discontinued as soon as possible if you become pregnant.

• Avalide