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Inclisiran is available as a 284 mg/1.5 mL (189 mg/mL) in a single-dose prefilled syringe.

Inclisiran is a siRNA and is used to treat high cholesterol, including heterozygous familial hypercholesterolemia (HeFH), in adults; as add-on to heart-healthy diet and statin therapy.

Inclisiran is a small interfering RNA (siRNA) medication. It gets absorbed into your liver and breaks down the gene that makes a protein called PCSK9. Normally, PCSK9 helps adjust the amount of cholesterol in your body. By stopping your liver from making PCSK9, Inclisiran helps your liver remove “bad” cholesterol (LDL, or low-density lipoprotein) from your body.

The typical dose of Inclisiran is 284 mg injected under the skin every 3 months for 2 doses, then given every 6 months thereafter.

Inclisiran is a safe and effective treatment when used for FDA licensed indications. However, like all medications, they may give you unwanted side effects. You should always discuss potential side effects with your physician to ensure the medication is suitable and right for you.

Common side effects of Inclisiran:

• Injection site reaction

Serious side effects are rare with Inclisiran.

There are no major drug interactions listed for Inclisiran. However, always let your physician and pharmacist know about any other medications or supplements (including prescribed and over-the-counter medications, vitamins, and dietary or herbal supplements) that you are currently taking.

Various FDA-approved generic manufacturers

Discontinue Inclisiran when pregnancy is recognized.

• Leqvio