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Idhifa is the brand name for enasidenib and is available as an oral tablet.

Idhifa is available as a 50 mg and 100 mg oral tablet.

Idhifa is an IDH2 inhibitor that is used to treat adults with relapsed or refractory acute myeloid leukemia (AML) with changes in the IDH2 gene.

Idhifa is an IDH2 inhibitor. When Idhifa blocks IDH2, it lowers the number of cancer cells and allows the young blood cells to mature into healthy cells.

Idhifa is typically dosed as 100 mg by mouth once daily.

Idhifa is a safe and effective treatment when used for FDA licensed indications. However, like all medications, they may give you unwanted side effects. You should always discuss potential side effects with your physician to ensure the medication is suitable and right for you.

Common side effects of Idhifa:

• Higher bilirubin
• Lower calcium levels
• Nausea
• Diarrhea
• Lower potassium levels
• Vomiting
• Lower appetite
• Lower phosphorus levels
• Differentiation syndrome
• Higher white blood cell counts
• Taste changes

Serious side effects are rare with Idhifa. Contact your healthcare provider immediately if you experience any of the following.

• Differentiation syndrome: fever, sudden weight gain, trouble breathing, chest pain, swelling in legs

There are no major drug interactions listed for Idhifa. However, always let your physician and pharmacist know about any other medications or supplements (including prescribed and over-the-counter medications, vitamins, and dietary or herbal supplements) that you are currently taking.

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Idhifa can cause harm to your unborn baby if taken during pregnancy. If you are able to become pregnant, your healthcare provider will do a pregnancy test before you start taking Idhifa. Females who are able to become pregnant and who take Idhifa should use effective birth control (contraception) during treatment with Idhifa and for at least 1 month after your last dose of Idhifa. Males who have female partners that are able to become pregnant should use effective birth control during treatment with Idhifa and for at least 1 month after your last dose of Idhifa. Idhifa may affect how hormonal contraceptives work and may cause them to not work as well. Talk to your healthcare provider about birth control methods that may be right for you while taking Idhifa.

• Enasidenib