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Icatibant is available as a 10 mg/ml subcutaneous injection.

Icatibant is a bradykinin B2 receptor antagonist and is used to treat treatment of sudden attacks of hereditary angioedema (HAE).

Icatibant is a bradykinin B2 receptor antagonist. It works by blocking the activity of a natural substance in the body called bradykinin. Bradykinin causes blood vessels to dilate (widen) and lead to swelling. In HAE, there’s too much bradykinin produced in your body, which causes severe swelling in different parts of your body (hands, feet, stomach, face, throat). By blocking bradykinin, Icatibant can help lower pain and swelling from an HAE attack.

Icatibant is typically started at 30 mg injected under the skin (subcutaneous) in the stomach area. If needed, additional doses can be given at least 6 hours apart, with a maximum of 3 doses in 24 hours.

Icatibant is a safe and effective treatment when used for FDA licensed indications. However, like all medications, they may give you unwanted side effects. You should always discuss potential side effects with your physician to ensure the medication is suitable and right for you.

Common side effects of Icatibant:

• Injection site reaction
• Fever
• Abnormal liver labs
• Dizziness
• Rash

Serious side effects are rare with Icatibant.

The following medications may interact with Icatibant:

• Icatibant is a bradykinin B2 receptor antagonist and thereby has the potential to have a pharmacodynamic interaction with ACE inhibitors where Icatibant may attenuate the antihypertensive effect of ACE inhibitors. Clinical trials to date have excluded subjects taking ACE inhibitors

Various FDA-approved generic manufacturers

It is not known if Icatibant will harm your unborn baby.
You and your healthcare provider will decide if Icatibant is right for you.

• Firazyr