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Hympavzi is the brand name for marstacimab-hncq and is available as a subcutaneous injection.

Hympavzi is available as a 150 mg/mL single-dose prefilled syringe or single-dose prefilled pen.

Hympavzi is a prescription medicine used for the routine prevention (prophylaxis) of bleeding episodes in adults and children aged 12 years and older with severe hemophilia A or hemophilia B, who have not developed inhibitors (antibodies) to traditional factor replacement therapies.

Hympavzi is a tissue factor pathway inhibitor (TFPI) antagonist. It works by blocking TFPI, a natural anticoagulant protein that typically prevents the body from forming blood clots efficiently. By inhibiting TFPI, Hympavzi rebalances the body’s clotting system, allowing for better blood clot formation and thus reducing bleeding frequency, without replacing the missing factors VIII or IX.

The recommended dosage of Hympavzi is:

• Loading dose: 300 mg (two 150 mg injections) by subcutaneous injection
• Maintenance dose: One week after the loading dose, initiate maintenance dosing of 150 mg every week by subcutaneous injection on the same day each week, at any time of day.
• Dose adjustment to 300 mg subcutaneous injection weekly can be considered.

Hympavzi is a safe and effective treatment when used for FDA licensed indications. However, like all medications, they may give you unwanted side effects. You should always discuss potential side effects with your physician to ensure the medication is suitable and right for you.

Common side effects of Hympavzi:

• Headache
• Injection site reactions
• Itchy skin

Serious side effects are rare with Hympavzi. Contact your healthcare provider immediately if you experience any of the following:

• Blood clots
• Allergic reaction

There are no major drug interactions listed for this medication. However, always let your physician and pharmacist know about any other medications or supplements (including prescribed and over-the-counter medications, vitamins, and dietary or herbal supplements) that you are currently taking.

Pfizer Inc.

Hympavzi may harm your unborn baby. Females who are able to become pregnant should have a pregnancy test before you start treatment. You should use effective birth control (contraception) during treatment and for 2 months after the last dose.

• Marstacimab-Hncq