HydrochlorothiazidePrices, Coupons & Savings

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*Based on the difference between the U&C price submitted and the price the patient paid, as of April 2023.

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  2. Hydrochlorothiazide
    Generic for Microzide
    30 capsules $4.2 USD
    Save $-4.20
  3. Hydrochlorothiazide
    Generic for Microzide
    30 tablets $3.6 USD
    Save $-3.60
  4. Hydrochlorothiazide
    Generic for Microzide
    30 tablets $3.9 USD
    Save $-3.90
  5. Hydrochlorothiazide
    Generic for Microzide
    90 tablets $8.7 USD
    Save $-8.70
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Do you need a prescription for hydrochlorothiazide?

Yes, hydrochlorothiazide is only available with a valid physician Rx.

How much is hydrochlorothiazide without Insurance in the US?

Our website gives two competitive savings options to US customers who wish to purchase hydrochlorothiazide, as either a brand or generic, if available. The first is access to medications through our mail-order online pharmacy. The second is by using the Now Patient Rx Advantage Card, which can be used in over 65,000 pharmacies nationwide, across America. If you are insured, then in most cases, the cash price will be significantly cheaper than the copay.

What will my out-of-pocket cost be for hydrochlorothiazide in the US?

There are no out-of-pocket (OOP) costs because we are currently only offering a cash-based option to purchase medications.

Is Now Patient a hydrochlorothiazide savings card?

Yes. Save up to 90% on your hydrochlorothiazide with the FREE Now Patient Rx Advantage card*.
*Based on the difference between the U&C submitted by the pharmacy and the price the patients pay.

Can you handle Rx transfers for home delivery in the US?

Yes. If you use the mail-order online pharmacy option, then we can handle requests by you to have your prescription transferred to our pharmacy for home delivery. We can even help you manage your refills by giving you timely reminders, so you do not run out of your medication.

Is Now Patient a hydrochlorothiazide coupon provider in the US?

No. Now Patient does not provide hydrochlorothiazide coupons or FREE hydrochlorothiazide samples.

Do you accept commercial, Medicare or Medicaid coverage for hydrochlorothiazide in the US?

No. Currently, we only offer cash-based options for purchase, therefore we do not require your insurance benefit details. In the future, our plan is to be able to handle commercial insurance, Medicare and Medicaid including cases where you have multiple health plans that provide benefit coverage (e.g. Medicaid and Commercial). We also anticipate being able to handle more complex scenarios such as using primary insurance combined with a manufacturer copay assistance program.

Does Now Patient work with Medicare?

Our cash-based prices for medications are typically cheaper than Medicare copays. We do not bill Medicare Part D (standalone drug coverage) or Medicare Advantage (combined health and drug coverage). When you purchase your medication from Now Patient, you will be doing so out of your pocket. The spend will not count towards your plan deductibles or gaps.

Does Now Patient work with Commercial Insurance?

Our cash-based prices for medications are typically cheaper than commercial plan copays. We do not bill your commercial plan. When you purchase your medication from Now Patient, you will be doing so out of your pocket. The spend will not count towards your plan deductibles or gaps.

What should you do if you use too much hydrochlorothiazide?


Call your doctor right away or seek immediate medical attention if your symptoms do not improve or they become worse after using hydrochlorothiazide. You can also call 800-222-1222 to reach the American Association of Poison Control Centers or use its online resource if you think you’ve used too much hydrochlorothiazide. But if you have severe symptoms, call 911 (or your local emergency number) immediately or go to the nearest emergency room.


If you think it is an emergency, call 999 or find your nearest A&E
If you need help now, but it’s not an emergency go to 111.nhs.uk or call 111. Alternatively you can speak to one of our pharmacists or use the Now Patient app to make an appointment with your GP.

What should I do if I miss my dose?

There are occasions when people forget to take their medication at correct prescribed times. This may not only have an effect on potentially making the medication less effective but it may also inadvertently lead to taking doses too close together, thereby increasing the risks of side effects.

Click here to find out what to do if you forgot to take your medication

What is generic hydrochlorothiazide?

US brand name of hydrochlorothiazide and manufacturer

Hydrochlorothiazide is available in the US under various brand names, including Microzide and Esidrix. It is manufactured by different pharmaceutical companies, including Mylan, Sandoz, and Teva.

UK brand name of hydrochlorothiazide and manufacturer

In the UK, hydrochlorothiazide is only available in fixed-dose combination with other medicines.

Prescription requirement for hydrochlorothiazide

Hydrochlorothiazide is a prescription medication in both the US and the UK. It is not available over the counter and requires a prescription from a healthcare provider.

FDA approval of hydrochlorothiazide

Hydrochlorothiazide has received FDA approval for the treatment of high blood pressure (hypertension) and edema (fluid retention).

Is hydrochlorothiazide available in the UK on NHS?

Hydrochlorothiazide is only available in fixed-dose combination with other medicines on the NHS in the UK.

Mechanism of action

Hydrochlorothiazide is a thiazide diuretic that works by increasing the excretion of water and electrolytes, including sodium and potassium, in the kidneys. This leads to increased urine production and helps reduce fluid volume in the body, resulting in decreased blood pressure.

Hydrochlorothiazide primarily works by increasing the amount of urine produced by the kidneys. This process helps the body eliminate excess salt and water, which in turn reduces fluid retention and lowers blood pressure.

The medication affects the kidneys’ ability to reabsorb sodium and chloride ions from the urine, thus increasing their excretion in the urine. As a result, the volume of fluid in the bloodstream decreases, reducing the pressure on the blood vessel walls, and consequently, lowering blood pressure.

Moreover, hydrochlorothiazide also relaxes the blood vessels, making it easier for blood to flow through them. By dilating the blood vessels, it reduces the resistance to blood flow, allowing the heart to pump more effectively and lowering blood pressure further.

Uses of hydrochlorothiazide

Hydrochlorothiazide commonly known as HCTZ is primarily used for the treatment of high blood pressure (hypertension). It may also be prescribed for other conditions, including edema (fluid retention) associated with congestive heart failure, kidney disorders, or certain liver conditions.

Hydrochlorothiazide can be used to treat calcium-containing kidney stones because it decreases the amount of calcium excreted by the kidneys in the urine and thus decreases the amount of calcium in urine to form stones.

Dosage of hydrochlorothiazide

The dosage of hydrochlorothiazide will vary depending on the individual patient’s condition, response to treatment, and other factors. It is important to follow the dosage instructions provided by your healthcare provider.

If you miss a dose, take it as soon as you remember. If it is near the time of the next dose, skip the missed dose. Take your next dose at the regular time. Do not double the dose to catch up. Store at room temperature away from moisture, heat, and freezing. Keep the bottle tightly closed when not in use.

Precautions and warnings for hydrochlorothiazide

  • Hydrochlorothiazide should not be used in individuals who have a known allergy to the medication or any of its components
  • It is important to inform your healthcare provider about any existing medical conditions, especially kidney disease, liver disease, diabetes, gout, or electrolyte imbalances
  • Hydrochlorothiazide may interact with certain medications, including other blood pressure medications, nonsteroidal anti-inflammatory drugs (NSAIDs), and certain diuretics. It is important to inform your healthcare provider about all the medications you are taking to avoid potential interactions
  • Hydrochlorothiazide may cause a drop in blood pressure, especially during the initial stages of treatment. It is important to monitor blood pressure regularly and report any significant changes to your healthcare provider
  • Hydrochlorothiazide may increase the risk of electrolyte imbalances, such as low potassium levels (hypokalemia) or sodium (hyponatremia). Regular monitoring of electrolyte levels may be recommended
  • It is important to stay adequately hydrated while taking hydrochlorothiazide to prevent dehydration
  • Using sunscreen and limiting sun exposure can help to prevent a reaction while you’re taking hydrochlorothiazide

Drug interactions

Some medications that may interact with hydrochlorothiazide include:

  • Taking hydrochlorothiazide along with other blood pressure medications, such as ACE inhibitors, beta-blockers, or calcium channel blockers, may lead to an excessive drop in blood pressure
  • Hydrochlorothiazide can increase the levels of lithium in the blood, potentially leading to lithium toxicity. Monitoring of lithium levels is necessary when using these medications together
  • Nonsteroidal anti-inflammatory drugs (NSAIDs) like ibuprofen or naproxen can reduce the effectiveness of hydrochlorothiazide and increase the risk of kidney problems
  • Taking hydrochlorothiazide with corticosteroids, such as prednisone, can increase the risk of low potassium levels in the blood
  • Medications cholestyramine and colestipol can decrease the absorption of hydrochlorothiazide, reducing its effectiveness
  • Hydrochlorothiazide can increase blood sugar levels, which may require adjustments in the dosage of diabetes medications

It is essential to discuss with your healthcare provider any medications you are currently taking including prescription drugs, over-the-counter medication and supplements before starting hydrochlorothiazide. They can determine if there are any potential adverse effects and make necessary adjustments to your treatment plan.

Side effects of hydrochlorothiazide

Common side effects of hydrochlorothiazide may include dizziness, lightheadedness, headache, fatigue, dry mouth, increased urination, and electrolyte imbalances. It may also rarely cause more serious side effects, such as allergic reactions, severe skin reactions, or liver or kidney problems. It is important to discuss any persistent or severe side effects with your healthcare provider.

Is it safe to take hydrochlorothiazide if I am pregnant or planning on becoming pregnant?

Hydrochlorothiazide should be used with caution during pregnancy. It may be prescribed in certain situations, but only if the potential benefits outweigh the potential risks. It is important to discuss the risks and benefits with your healthcare provider.

Is hydrochlorothiazide safe to use while breastfeeding?

Hydrochlorothiazide may pass into breast milk and could potentially affect the nursing infant. It is important to consult with your healthcare provider before using hydrochlorothiazide while breastfeeding to assess the potential risks and benefits.


Stefano Mirabello Medical Reviewer
Pharmacist / B.Pharm
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