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Humira is the brand name for adalimumab and is available as a subcutaneous injection.

Humira is available as a prefilled pen and glass syringe in various strengths.

Humira is a biologic DMARD and is used for the following:

• Rheumatoid arthritis (RA) – adults only
• Juvenile idiopathic arthritis (JIA) – people age 2 and older
• Psoriatic arthritis (PsA) – adults only
• Ankylosing spondylitis (AS) – adults only
• Crohn’s disease (CD) – people age 6 and older
• Ulcerative colitis (UC) – people age 5 and older
• Plaque psoriasis – adults only
• Hidradenitis suppurativa (HS) – people age 12 and older
• Uveitis – people age 2 and older

Humira is a biologic disease-modifying antirheumatic drug (DMARD). It blocks tumor necrosis factor (TNF), which is a protein in your body that plays a role in inflammation. By blocking TNF, Humira lowers inflammation to relieve symptoms in the joints, skin, and gut.

Humira is typically dosed as follows:

Adults

• Rheumatoid arthritis, psoriatic arthritis, and ankylosing spondylitis: The typical dose is 40 mg injected under the skin every other week
• Crohn’s disease and ulcerative colitis: The typical dose is 160 mg injected under the skin on Day 1, followed by 80 mg on Day 15, then 40 mg every other week starting Day 29
• Plaque psoriasis and uveitis: The typical dose is 80 mg injected under the skin on Day 1, followed by 40 mg every other week starting 1 week after the first dose
• Hidradenitis suppurativa: The typical dose is 160 mg injected under the skin on Day 1, followed by 80 mg on Day 15, then 40 mg every week OR 80 mg every other week starting Day 29

Children

• Juvenile idiopathic arthritis and uveitis: The dose is based on your child’s body weight. Typically it will be injected under the skin every other week
• Crohn’s disease, ulcerative colitis, and hidradenitis suppurativa: The dose is based on your child’s body weight and the condition being treated. Typically it injected under the skin either every week or every other week

Humira is a safe and effective treatment when used for FDA licensed indications. However, like all medications, they may give you unwanted side effects. You should always discuss potential side effects with your physician to ensure the medication is suitable and right for you.

Common side effects of Humira:

• Injection-site reaction
• Upper respiratory tract infection
• Headache
• Rash
• Sinus inflammation
• Accidental injury
• Nausea
• Urinary tract infection (UTI) or bladder infection

Serious side effects are rare with Humira. Contact your healthcare provider immediately if you experience any of the following.

• Serious infection: fever, cough, weight loss, muscle aches, dark urine, chills, vomiting
• Low blood cell counts: fever that doesn’t go away, easy bruising or bleeding, pale skin
• Severe allergic reaction: rash, trouble breathing, swelling of your face, eyes, lips, or mouth, hives
• Heart failure: shortness of breath, swelling in the legs, ankles, or feet, irregular heartbeat, tiredness, sudden weight gain
• Liver problems: feeling tired, vomiting, yellow skin or whites of the eyes, stomach pain

The following medications may interact with Humira:

• Abatacept: Increased risk of serious infection.
• Anakinra: Increased risk of serious infection.
• Live vaccines: Avoid use with Humira.

AbbVie Inc.

Humira can cross the placenta during the third trimester of pregnancy and may affect immune response in the exposed infant. If you become pregnant while receiving Humira, talk to your healthcare provider.

• Adalimumab