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Human Insulin is available as 100 units/mL (U-100) in a 10 mL multiple-dose vial and 3 mL single-patient-use FlexPen.

Human Insulin contains two types of insulin and is used to treat Type 1 and Type 2 diabetes in adults and children.

Human Insulin has two types of insulin:

• 70% insulin NPH (or “isophane insulin”) and 30% insulin regular. It helps your body absorb and store sugar from the bloodstream after a meal. Insulin also stops your liver from making glucose (sugar).

Your dose of Human Insulin will be based on several factors, such as your blood sugar levels and your body weight. Typically, Human Insulin is injected under the skin about 30 minutes before a meal. It is usually used twice per day.

Human Insulin is a safe and effective treatment when used for FDA licensed indications. However, like all medications, they may give you unwanted side effects. You should always discuss potential side effects with your physician to ensure the medication is suitable and right for you. You should not use this medication in the following:

• During episodes of low blood sugar (hypoglycemia)

Common side effects of Human Insulin:

• Low blood sugar
• Injection site reactions
• Weight gain
• Swelling
• Fat deposits under the skin or pitting of the skin where the medication is injected

Serious side effects are rare with Human Insulin. Contact your healthcare provider immediately if you experience any of the following:

• Severely low blood sugar: dizziness, shakiness, feeling confused, feeling irritable or anxious, feeling faint, sweating, extreme hunger, can’t think clearly
• Dangerously low potassium levels: weakness, muscle cramps or twitches, constipation, abnormal heartbeat, tiredness, trouble breathing
• Severe allergic reaction: rash; hives; swelling of the face, tongue, and throat; trouble breathing

The following medications may interact with Human Insulin:

• Drugs that affect glucose levels
• Antiadrenergic drugs (e.g., beta-blockers, clonidine, guanethidine, and reserpine)

Various FDA-approved generic manufacturers

It is not known whether this medication is safe for you and your unborn baby during pregnancy. However, there are risks to the mother and fetus associated with poorly controlled diabetes in pregnancy. Talk to your doctor if you are already pregnant or if you have plans on becoming pregnant. They will recommend what is best for you.

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