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Glucotrol XL is the brand name for glipizide and is available as an extended-release oral tablet.

Glucotrol XL is available as a 2.5 mg, 5 mg, 10 mg extended-release oral tablet.

Glucotrol XL is a sulfonylurea and is used to treat type 2 diabetes.

Glucotrol XL is a sulfonylurea. It lowers blood sugar levels by telling your pancreas to release more insulin.

Glucotrol XL is typically dosed as 5 mg by mouth before breakfast. If needed, your provider will raise your dose every few days. The maximum recommended dose is 20 mg once daily.
Your dose of glipizide might be lower if you’re an older adult, have liver problems, or are taking other blood sugar medications.

Glucotrol XL is a safe and effective treatment when used for FDA licensed indications. However, like all medications, they may give you unwanted side effects. You should always discuss potential side effects with your physician to ensure the medication is suitable and right for you. You should not use this medication if you have a hypersensitivity to the drug or type 1 diabetes mellitus, diabetic ketoacidosis, with or without coma.

Common side effects of Glucotrol XL include:

• Dizziness
• Diarrhea
• Nervousness
• Tremor
• Passing gas
• Low blood sugar levels

Serious side effects are rare with Glucotrol XL. Contact your healthcare provider immediately if you experience any of the following.

• Dangerously low blood sugar levels: feeling hungry, fast heartbeat, shakiness, anxiety, sweating, tingling, dizziness, weakness, drowsiness, confusion, coma

The following medications may interact with Glucotrol XL:

• Miconazole – Monitor patients closely. Severe hypoglycemia can occur when Glucotrol XL and oral miconazole are used concomitantly
• Fluconazole – Monitor patients closely. An increase in Glucotrol XL levels was seen after fluconazole administration
• Colesevelam – Glucotrol XL should be administered at least 4 hours prior to colesevelam

Pfizer

Glucotrol XL has not shown any drug associated risks for major birth defects, miscarriage, or adverse maternal outcomes from a small number of published studies and postmarketing experience with Glucotrol XL use in pregnancy over decades. However, sulfonylureas (including glipizide) cross the placenta and have been associated with neonatal adverse reactions such as hypoglycemia. Therefore, Glucotrol XL should be discontinued at least two weeks before expected delivery.

• Glipizide