View GLUCOTROL XL savings options available to you including Manufacturer Coupons, Rx Advantage Savings Card, Canadian Prescription Savings or GLUCOTROL XL Patient Assistance Program.

Programs are suitable for individuals who want to buy GLUCOTROL XL without insurance, with insurance or for those who are underinsured. You can pay as little as $0 per fill.*

Manufactured by Pfizer

*Applicable to Drug Coupons & Patient Assistance Programs

This content is intended for US audiences only

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Jamie Winn NowPatientGreen tick
Updated on 26 Apr 2024

Learn more about GLUCOTROL XL



GLUCOTROL XL is the brand name for glipizide and is available as an extended-release oral tablet.

What dosages is GLUCOTROL XL available in?

What dosages is GLUCOTROL XL available in?

GLUCOTROL XL is available as a 2.5 mg, 5 mg, 10 mg extended-release oral tablet.

What is GLUCOTROL XL used for?

What is GLUCOTROL XL used for?

GLUCOTROL XL is a sulfonylurea and is used to treat type 2 diabetes.

How does GLUCOTROL XL work?

How does GLUCOTROL XL work?

GLUCOTROL XL is a sulfonylurea. It lowers blood sugar levels by telling your pancreas to release more insulin.

How do I take GLUCOTROL XL?

How do I take GLUCOTROL XL?

GLUCOTROL XL is typically dosed as 5 mg by mouth before breakfast. If needed, your provider will raise your dose every few days. The maximum recommended dose is 20 mg once daily.
Your dose of glipizide might be lower if you’re an older adult, have liver problems, or are taking other blood sugar medications.

Is it safe for me to take GLUCOTROL XL?

Is it safe for me to take GLUCOTROL XL?

GLUCOTROL XL is a safe and effective treatment when used for FDA licensed indications. However, like all medications, they may give you unwanted side effects. You should always discuss potential side effects with your physician to ensure the medication is suitable and right for you. You should not use this medication if you have a hypersensitivity to the drug or type 1 diabetes mellitus, diabetic ketoacidosis, with or without coma.

GLUCOTROL XL Common Side Effects

GLUCOTROL XL Common Side Effects

Common side effects of GLUCOTROL XL include:

  • Dizziness
  • Diarrhea
  • Nervousness
  • Tremor
  • Passing gas
  • Low blood sugar levels
GLUCOTROL XL Serious Side Effects

GLUCOTROL XL Serious Side Effects

Serious side effects are rare with GLUCOTROL XL. Contact your healthcare provider immediately if you experience any of the following.

  • Dangerously low blood sugar levels: feeling hungry, fast heartbeat, shakiness, anxiety, sweating, tingling, dizziness, weakness, drowsiness, confusion, coma
Effects of other drugs, drug classes and over-the-counter products on GLUCOTROL XL

Effects of other drugs, drug classes and over-the-counter products on GLUCOTROL XL

The following medications may interact with GLUCOTROL XL:

  • Miconazole – Monitor patients closely. Severe hypoglycemia can occur when GLUCOTROL XL and oral miconazole are used concomitantly
  • Fluconazole – Monitor patients closely. An increase in GLUCOTROL XL levels was seen after fluconazole administration
  • Colesevelam – GLUCOTROL XL should be administered at least 4 hours prior to colesevelam



Is GLUCOTROL XL safe in pregnancy?

Is GLUCOTROL XL safe in pregnancy?

GLUCOTROL XL has not shown any drug associated risks for major birth defects, miscarriage, or adverse maternal outcomes from a small number of published studies and postmarketing experience with GLUCOTROL XL use in pregnancy over decades. However, sulfonylureas (including glipizide) cross the placenta and have been associated with neonatal adverse reactions such as hypoglycemia. Therefore, GLUCOTROL XL should be discontinued at least two weeks before expected delivery.


What to do if you missed your GLUCOTROL XL dose

The FDA's medical product safety reporting program for health professionals, patients and consumers.

Learn more about reporting side effects
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Medical Disclaimer

NowPatient has taken all reasonable steps to ensure that all material is factually accurate, complete, and current. However, the knowledge and experience of a qualified healthcare professional should always be sought after instead of using the information on this page. Before taking any drug, you should always speak to your doctor or another qualified healthcare provider.

The information provided here about medications is subject to change and is not meant to include all uses, precautions, warnings, directions, drug interactions, allergic reactions, or negative effects. The absence of warnings or other information for a particular medication does not imply that the medication or medication combination is appropriate for all patients or for all possible purposes.

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