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Glipizide is available as a 2.5 mg, 5 mg, and 10 mg oral tablet.

Glipizide is a sulfonylurea and is used to treat type 2 diabetes.

Glipizide is a sulfonylurea. It lowers blood sugar levels by telling your pancreas to release more insulin.

Glipizide is typically dosed as 5 mg by mouth before breakfast. If needed, your provider will raise your dose every few days. If your total daily is higher than 15 mg, your provider will prescribe it as divided doses, taken twice daily. The maximum recommended daily dose is 40 mg total. Your dose of Glipizide might be lower if you’re an older adult, have liver problems, or are taking other blood sugar medications.

Glipizide is a safe and effective treatment when used for FDA licensed indications. However, like all medications, they may give you unwanted side effects. You should always discuss potential side effects with your physician to ensure the medication is suitable and right for you. You should not use this medication if you have a hypersensitivity to the drug or type 1 diabetes mellitus, diabetic ketoacidosis, with or without coma.

Common side effects of Glipizide include:

• Dizziness
• Diarrhea
• Nervousness
• Tremor
• Passing gas
• Low blood sugar levels

Serious side effects are rare with Glipizide. Contact your healthcare provider immediately if you experience any of the following.

• Dangerously low blood sugar levels: feeling hungry, fast heartbeat, shakiness, anxiety, sweating, tingling, dizziness, weakness, drowsiness, confusion, coma

The following medications may interact with Glipizide:

• Miconazole – Monitor patients closely. Severe hypoglycemia can occur when Glipizide and oral miconazole are used concomitantly
• Fluconazole – Monitor patients closely. An increase in Glipizide levels was seen after fluconazole administration
• Colesevelam – Glipizide should be administered at least 4 hours prior to colesevelam

Various FDA-approved generic manufacturers

Glipizide has not shown any drug associated risks for major birth defects, miscarriage, or adverse maternal outcomes from a small number of published studies and postmarketing experience with Glipizide use in pregnancy over decades. However, sulfonylureas (including Glipizide) cross the placenta and have been associated with neonatal adverse reactions such as hypoglycemia. Therefore, Glipizide should be discontinued at least two weeks before expected delivery.

• Glucotrol
• Glucotrol XL