GAZYVA
Used for Cancer
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Manufactured by Genentech, Inc.
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GAZYVA Uses, Side Effects, Interactions, Warnings & Dosing
What is GAZYVA?
GAZYVA is the brand name for obinutuzumab IV infusion.
What dosages is GAZYVA available in?
GAZYVA is available as a 1,000 mg/40 mL (25 mg/mL) single-dose vial.
What is GAZYVA used for?
GAZYVA is a monoclonal antibody that is used to treat:
- Chronic lymphocytic leukemia (CLL)
- Follicular lymphoma (FL)
How does GAZYVA work?
GAZYVA is a monoclonal antibody that attaches to specific proteins called CD20 on B cells. B cells are a type of white blood cell. They are a part of your immune system and help your body make antibodies. Cancer cells usually have more CD20 proteins than normal, healthy cells. When GAZYVA attaches to CD20, an immune response gets triggered. Signals get sent out to attack and kill the cells that the medication is attached to. GAZYVA can also signal the cancer cells to die directly.
How do I take GAZYVA?
This medication is an injection into a vein (intravenously or IV) that’s given by a healthcare provider. The typical dose is 1,000 mg per infusion. GAZYVA is given weekly for the first 3 weeks in your first cycle. Then, it’s given every 3 to 4 weeks for future cycles, depending on your treatment regimen. Due to the risk for infusion reactions, your very first infusion will be split over 2 days, with 100 mg on the first day, then 900 mg on the second day.
Is it safe for me to take GAZYVA?
GAZYVA is a safe and effective treatment when used for FDA licensed indications. However, like all medications, they may give you unwanted side effects. You should always discuss potential side effects with your physician to ensure the medication is suitable and right for you. GAZYVA is contraindicated in patients with known hypersensitivity reactions (e.g., anaphylaxis) to obinutuzumab or any of the excipients, including serum sickness with prior obinutuzumab use.
GAZYVA Common Side Effects
Common side effects of GAZYVA:
- Infusion-related reactions
- Infections of the nose, throat, or lungs
- Cough
- Muscle, bone, or joint pain
- Fever
GAZYVA Serious Side Effects
Serious side effects are rare with GAZYVA. Contact your healthcare provider immediately if you experience any of the following.
- Serious infusion-related or allergic reactions: throat tightness, trouble breathing, itching or hives, swelling, chest pain, fast heartbeat, dizziness, flushing, chills, fever
- Infections (general): repeated fevers, chills, cough, trouble breathing, severe diarrhea, vomiting, painful urination, urinating more often than usual
- Brain infection: changes in mood or behavior, difficulty concentrating, vision loss, weakness, facial drooping, issues with balance or walking
- Serious bleeds: bleeding or bruising that doesn’t stop or go away, large amount of bleeding, blood in the urine, throwing up blood, bloody or black and tarry stool
Effects of other drugs, drug classes and over-the-counter products on GAZYVA
- There are no major drug interactions listed for GAZYVA. However, always let your physician and pharmacist know about any other medications or supplements (including prescribed and over-the-counter medications, vitamins, and dietary or herbal supplements) that you are currently taking
Who makes GAZYVA?
Genentech, Inc.
Is GAZYVA safe in pregnancy?
Based on its mechanism of action and findings in animals, GAZYVA can cause B-cell depletion in infants exposed to obinutuzumab. Females of reproductive potential to use effective contraception while receiving GAZYVA and for 6 months after the last dose
The FDA's medical product safety reporting program for health professionals, patients and consumers.
Learn more about reporting side effects
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Medical Disclaimer
NowPatient has taken all reasonable steps to ensure that all material is factually accurate, complete, and current. However, the knowledge and experience of a qualified healthcare professional should always be sought after instead of using the information on this page. Before taking any drug, you should always speak to your doctor or another qualified healthcare provider.
The information provided here about medications is subject to change and is not meant to include all uses, precautions, warnings, directions, drug interactions, allergic reactions, or negative effects. The absence of warnings or other information for a particular medication does not imply that the medication or medication combination is appropriate for all patients or for all possible purposes.
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