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Fruzaqla is the brand name for fruquintinib and is available as an oral capsule.

Fruzaqla is available as 1 mg and 5 mg oral capsule.

Fruzaqla is a kinase inhibitor indicated for the treatment of adult patients with metastatic colorectal cancer (mCRC) who have been previously treated with fluoropyrimidine-, oxaliplatin-, and irinotecan-based chemotherapy, an anti-VEGF therapy, and, if RAS wild-type and medically appropriate, an anti-EGFR therapy.

Fruzaqla works by blocking a protein that causes cancer cells to grow and multiply. This helps to slow or stop the spread of cancer cells.

The recommended dose of Fruzaqla is 5 mg orally once daily, with or without food for the first 21 days of each 28-day cycle

Fruzaqla is a safe and effective treatment when used for FDA licensed indications. However, like all medications, they may give you unwanted side effects. You should always discuss potential side effects with your physician to ensure the medication is suitable and right for you.

Common side effects of Fruzaqla:

• Hypertension
• Palmar-plantar erythrodysesthesia (a skin reaction that affects the palms of your hands and the soles of your feet)
• Abdominal pain
• Diarrhea

Serious side effects are rare with Fruzaqla. Contact your doctor if you experience any of the following.

• Severe bleeding (hemorrhage).
• Infections
• A tear in your stomach or intestinal wall (gastrointestinal perforation)
• Liver problems
• Posterior Reversible Encephalopathy Syndrome (PRES)
• Wound healing problems
• Blood clots in your blood vessels (arteries)

The following medications may interact with Fruzaqla:

• Strong or Moderate CYP3A Inducers: Avoid concomitant use

Takeda Pharmaceuticals

Fruzaqla can harm your unborn baby. You should not become pregnant during treatment with Fruzaqla. If you can become pregnant, your healthcare provider will do a pregnancy test before you start treatment with Fruzaqla. Use effective birth control (contraception) during treatment and for 2 weeks after your last dose of Fruzaqla. Tell your healthcare provider right away if you become pregnant during treatment with Fruzaqla. Males with female partners who can become pregnant should use effective birth control during treatment and for 2 weeks after your last dose of Fruzaqla. Tell your healthcare provider right away if your partner becomes pregnant during your treatment with Fruzaqla.

• Fruqintinib