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Fluorouracil is available as a 2% and 5% topical solution and a 5% topical cream.

Fluorouracil is an antimetabolite and is used for the following:
Actinic (or solar) keratosis (scaly pre-cancerous spot or growth on the skin) in adults Basal cell carcinoma (certain type of skin cancer) in adults

Fluorouracil is an antimetabolite. It works by getting in the way of cells making copies of their genetic material. When applied on pre-cancerous or cancerous skin cells, Fluorouracil topical prevents them from being able to grow.

Fluorouracil is dosed as follows:

Actinic keratoses

• Fluorouracil 2% and 5%: Apply a thin layer to cover the skin spots or growths on the affected area(s) twice daily. The typical length of treatment is 2 to 4 weeks. But it can take 1 to 2 months after the end of treatment to notice complete healing of the skin

Basal cell carcinoma

• Fluorouracil 5% only: Apply a thin layer to cover the skin spots or growths on the affected area(s) twice daily. The typical length of treatment is 3 to 6 weeks, but can be extended to up to 3 months, if needed

Fluorouracil is a safe and effective treatment when used for FDA licensed indications. However, like all medications, they may give you unwanted side effects. You should always discuss potential side effects with your physician to ensure the medication is suitable and right for you. You should not use this medication if you are pregnant.

Common side effects of Fluorouracil:

• Crusting of the skin
• Stinging or burning feeling of the skin
• Itchiness
• Soreness on the skin
• Scarring

Serious side effects are rare with Fluorouracil. Contact your healthcare provider immediately if you experience any of the following.

• Rare toxicity reaction: Stomach pains, bloody diarrhea, vomiting, fever, chills, skin rash, painful sores in the mouth

There are no major drug interactions listed for Fluorouracil. However, always let your physician and pharmacist know about any other medications or supplements (including prescribed and over-the-counter medications, vitamins, and dietary or herbal supplements) that you are currently taking.

Various FDA-approved generic manufacturers

Fluorouracil is contraindicated in women who are or may become pregnant during therapy. If this drug is used during pregnancy, or if the patient becomes pregnant while using this drug, the patient should be apprised of the potential hazard to the fetus

• Efudex