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Finerenone is available as a 10 mg and 20 mg oral tablet.

Finerenone is a mineralocorticoid receptor antagonist and is used for the following:

Lowers the risk of the following problems in adults with long-term kidney problems (also called chronic kidney disease (CKD)) associated with type 2 diabetes:

• Worsening kidney function
• Death due to heart problems
• Heart attack
• Hospitalization due to heart failure

Finerenone is a mineralocorticoid receptor antagonist. It works by stopping mineralocorticoids (e.g., aldosterone) from binding (attaching) to their receptors in your kidneys, heart, and blood vessels. This prevents inflammation and damage to your kidneys, heart, and blood vessels.

The typical dose is 10 mg to 20 mg by mouth once daily, depending on how well your kidneys work. Your provider will adjust the dose based on your blood potassium level, kidney function, and if you’re having side effects.

Finerenone is a safe and effective treatment when used for FDA licensed indications. However, like all medications, they may give you unwanted side effects. You should always discuss potential side effects with your physician to ensure the medication is suitable and right for you. You should not use this medication in the following.

• Concomitant use with strong CYP3A4 inhibitors
• Patients with adrenal insufficiency

Common side effects of Finerenone:

• High blood potassium levels

Serious side effects are rare with Finerenone. Contact your healthcare provider immediately if you experience any of the following.

• Low blood pressure: dizziness, tiredness, feeling faint, confusion
• Very high potassium level: nausea, chest pain, irregular heartbeat, muscle weakness, numbness and tingling

• The following medications may interact with Finerenone:
• Strong CYP3A4 Inhibitors: Use is contraindicated
• Grapefruit or grapefruit juice: Avoid concomitant use.
• Moderate or weak CYP3A4 Inhibitors: Monitor serum potassium during drug initiation or dosage adjustment of either Finerenone or the moderate or weak CYP3A4 inhibitor, and adjust Finerenone dosage as appropriate
• Strong or moderate CYP3A4 Inducers: Avoid concomitant use

Various FDA-approved generic manufacturers

It is not known if Finerenone will harm your unborn baby. Tell your healthcare provider if you become pregnant while taking Finerenone.

• Kerendia