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Etelcalcetide is available as a 2.5 mg/0.5 mL, 5 mg/mL or 10 mg/2 mL solution in a single-dose vial.

Etelcalcetide is a calcimimetic and is used to treat secondary hyperparathyroidism (too much parathyroid hormone in the body) in adults with chronic kidney disease on dialysis.

Etelcalcetide is a calcimimetic, meaning it acts like calcium in your body. It activates a protein called the calcium-sensing receptor in your parathyroid glands (small pea-like structures in your neck). This lowers the amount of parathyroid hormone (PTH) produced in your body, which in turn, lowers your blood calcium level.

Etelcalcetide is dosed as follows:

• Etelcalcetide is usually given in a healthcare setting or dialysis unit by a healthcare provider. Your provider will make sure you get this medication at the correct dose and time
• The typical starting dose is 5 mg given by injection into your vein (IV) 3 times a week at the end of each hemodialysis treatment. The typical maintenance dose can range from 2.5 mg to 15 mg injected IV 3 times a week, depending on your PTH and calcium levels

Etelcalcetide is a safe and effective treatment when used for FDA licensed indications. However, like all medications, they may give you unwanted side effects. You should always discuss potential side effects with your physician to ensure the medication is suitable and right for you.

Common side effects of Etelcalcetide:

• Muscle cramps, tingling sensation in hands and feet, and other symptoms of low calcium levels
• Muscle spasms
• Diarrhea
• Nausea
• Vomiting
• Headache
• Pins and needles feeling

Serious side effects are rare with Etelcalcetide. Contact your healthcare provider immediately if you experience any of the following.

• Dangerously low blood calcium levels: muscle pain or spasms, seizures, irregular heart rhythm(s)

There are no major drug interactions listed for Etelcalcetide. However, always let your physician and pharmacist know about any other medications or supplements (including prescribed and over-the-counter medications, vitamins, and dietary or herbal supplements) that you are currently taking.

Various FDA-approved generic manufacturers

It is not known if Etelcalcetide can harm your unborn baby. Talk to your healthcare provider if you are pregnant or plan to become pregnant.

• Parsabiv