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Estradiol Transdermal System is available as a transdermal system that contains 14 mcg per day.

Estradiol Transdermal System is an estrogen replacement and is used to treat prevent bone loss (osteoporosis) after menopause.

Estradiol Transdermal System contains estrogen, which is a natural hormone in your body that helps keep your bones healthy. During menopause, your body makes less estrogen, which puts you at a greater risk for bone loss (osteoporosis). By adding or replacing estrogen, Estradiol Transdermal System helps to lower that risk by preventing bone loss.

The typical dose for Estradiol Transdermal System is one patch per week applied to your lower stomach or upper buttocks.

Estradiol Transdermal System is a safe and effective treatment when used for FDA licensed indications. However, like all medications, they may give you unwanted side effects. You should always discuss potential side effects with your physician to ensure the medication is suitable and right for you. You should not use this medication if you have any of the following.

• Undiagnosed abnormal genital bleeding
• Breast cancer or a history of breast cancer
• Estrogen-dependent neoplasia. Active DVT, PE or a history of these conditions
• Active arterial thromboembolic disease (for example, stroke or MI), or a history of these conditions
• Known anaphylactic reaction, or angioedema, or hypersensitivity to Estradiol Transdermal System
• Hepatic impairment or disease
  Protein C, protein S, or antithrombin deficiency, or other
• known thrombophilic disorders

Common side effects of Estradiol Transdermal System:

• Upper respiratory infection
• Accidental injury
• Body pain
• Joint pain
• Vaginal discharge
• Application site reaction
• Stomach pain
• Bronchitis
• Growths on the cervix
• Breast pain
• Constipation
• Indigestion
• Dizziness
• Muscle pain or weakness
• Swelling of the joints

Serious side effects are rare with Estradiol Transdermal System. Contact your healthcare provider immediately if you experience any of the following.

• Stroke: weakness or numbness of arms, legs, or face on one side of the body, slurred speech, blurred vision, headache, dizziness, loss of balance, trouble walking, confusion
• Heart attack: chest pain or discomfort, chest tightness, trouble breathing, nausea, vomiting, dizziness, sweating, fast heartbeat
• Blood clots: legs (cramps, swelling, pain, muscle tightness) and lungs (trouble breathing, chest pain, cough)
• Breast lumps: breast pain or soreness, swelling, rash
• Unusual vaginal bleeding: abnormal spotting or bleeding

The following medications may interact with Estradiol Transdermal System:

• Inducers and/or inhibitors of CYP3A4 may affect estrogen drug metabolism and decrease or increase the estrogen plasma concentration

Various FDA-approved generic manufacturers

Estradiol Transdermal System is not indicated for use in pregnancy.

• Menostar