estradiol/levonorgestrel
Used for Birth Control
Are you tired of high medication costs? Our service offers unbeatable savings on your estradiol/levonorgestrel prescription medication. We provide a range of solutions to help you save up to 100% on your medication costs*. Whether you are insured, uninsured, underinsured, or simply looking to reduce your out-of-pocket expenses, we've got you covered.
Manufactured by various FDA-approved generic manufacturers.
*You can pay as little as $0 per fill using Drug Coupons or Patient Assistance Programs. Subject to applicability & eligibility requirements.
This content is intended for US audiences only
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Lower the cost of your estradiol/levonorgestrel prescription
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estradiol/levonorgestrel key facts
What dosages is estradiol/levonorgestrel available in?
estradiol/levonorgestrel is available as a transdermal system that contains 0.045 mg/day estradiol and 0.015 mg/day levonorgestrel.
What is estradiol/levonorgestrel used for?
estradiol/levonorgestrel is an estrogen replacement/progestin that is used in women who have gone through menopause with a healthy uterus for the:
- Treatment of moderate-to-severe menopausal symptoms (e.g., hot flashes, night sweats)
- Prevention of osteoporosis
How does estradiol/levonorgestrel work?
estradiol/levonorgestrel is a combination of two medications that act as natural hormones to balance the hormonal changes your body goes through during and after menopause.
- Estradiol is an estrogen replacement. By providing your body with a form of estrogen, estradiol relieves menopausal symptoms caused by low estrogen, such as hot flashes and night sweats. In addition, estrogen and estradiol prevent bone loss and make bone stronger
- Levonorgestrel is a progestin. It acts like progesterone and helps balance the effect of estrogen on the growth of your uterine lining
How do I take estradiol/levonorgestrel?
Apply 1 patch to your lower stomach once a week on the same day of the week. Each patch gives you 0.045 mg of estradiol and 0.015 mg of levonorgestrel a day.
Is it safe for me to take estradiol/levonorgestrel?
estradiol/levonorgestrel is a safe and effective treatment when used for FDA licensed indications. However, like all medications, they may give you unwanted side effects. You should always discuss potential side effects with your physician to ensure the medication is suitable and right for you. You should not use this medication in the following:
- Undiagnosed abnormal genital bleeding
- Breast cancer or a history of breast cancer
- Estrogen-dependent neoplasia
- Active DVT, PE or a history of these conditions
- Active arterial thromboembolic disease (for example, stroke and MI), or a history of these conditions
- Known anaphylactic reaction or angioedema or hypersensitivity to estradiol/levonorgestrel
- Hepatic impairment or disease
- Protein C, protein S, or antithrombin deficiency, or other thrombophilic disorders
estradiol/levonorgestrel Common Side Effects
Common side effects of estradiol/levonorgestrel:
- Application site reaction
- Vaginal bleeding
- Breast pain
- Sore throat, runny nose, nasal congestion, or cough
- Depression
- Back pain
- General pain
- Headache
- Flu-like symptoms
estradiol/levonorgestrel Serious Side Effects
Serious side effects are rare with estradiol/levonorgestrel. Contact your healthcare provider immediately if you experience any of the following.
- Blood clots: trouble breathing, leg pain or swelling, skin that’s warm to the touch
- Heart attack: chest pain, arm pain, shortness of breath, cold sweat, lightheadedness
- Stroke: sudden weakness on one side of your body, drooping face, changes in your speech or vision, confusion, headache
Effects of other drugs, drug classes and over-the-counter products on estradiol/levonorgestrel
The following medications may interact with estradiol/levonorgestrel:
- Inducers and/or inhibitors of CYP3A4 may affect estrogen drug metabolism and decrease or increase the estrogen plasma concentration
- Hydroxylation of levonorgestrel may interact with inhibitors of CYP3A
- CYP2E and CYP2C and decrease the therapeutic effects.
Who makes estradiol/levonorgestrel?
Various FDA-approved generic manufacturers
Is estradiol/levonorgestrel safe in pregnancy?
estradiol/levonorgestrel is not indicated for use in pregnancy.
The FDA's medical product safety reporting program for health professionals, patients and consumers.
Learn more about reporting side effectsDrug Savings Guide
A practical guide to saving money and receiving support with prescription costs
How can NowPatient help me to lower the cost of my estradiol/levonorgestrel prescription?
After you create a FREE account with NowPatient, you will have access to 4 programs that can help lower the cost of your estradiol/levonorgestrel prescription
Applicability to each program will be dependent on your insurance status.
How do the NowPatient estradiol/levonorgestrel savings programs work?
After you have created your FREE account with NowPatient, you can access the various programs from your account dashboard. Each program has clear instructions on how to check your eligibility. You can see how the process works by clicking on the feature link below and seeing the ‘How it works’ steps.
Drug Coupon and Patient Assistance Programs require an eligibility quiz to be completed.
Are the NowPatient estradiol/levonorgestrel savings programs suitable for everyone, regardless of insurance status?
No. Each program has its own eligibility and applicability requirements. The table below shows if a program is available to you, based on your insurance status.
| Rx Advantage Card* for estradiol/levonorgestrel | Canadian Prescription Savings* for estradiol/levonorgestrel | estradiol/levonorgestrel Drug Coupon* | estradiol/levonorgestrel Patient Assistance Program* | |
| Insured (federal, state or government) | Available | Available | Not Available | Available If Offered by Pharmaceutical Company |
| Insured (Commercial or Private) | Available | Available | Available If Offered by Pharmaceutical Company | Available If Offered by Pharmaceutical Company |
| Uninsured | Available | Available | Not Available | Available If Offered by Pharmaceutical Company |
| Insured but without pharmacy benefit or drug coverage | Available | Available | Not Available | Available If Offered by Pharmaceutical Company |
*This is not insurance.
Are the NowPatient drug savings programs suitable for brand and generic versions of estradiol/levonorgestrel?
No. Each program has applicability requirements. Please see below
| Rx Advantage Card* for estradiol/levonorgestrel | Canadian Prescription Savings* for estradiol/levonorgestrel | estradiol/levonorgestrel Drug Coupon* | estradiol/levonorgestrel Patient Assistance Program* | |
| Brand | Yes | Yes | Yes, If Offered by Pharmaceutical Company | Yes, If Offered by Pharmaceutical Company |
| Generic | Yes | Yes | No | No |
*This is not insurance.
If you have Medicare Part D or Medicare Advantage and none of the estradiol/levonorgestrel savings options are applicable or affordable for me, what can you do?
If you are insured with Medicare and the estradiol/levonorgestrel drug savings options are not applicable to you and still remain unaffordable, then you can check Medicaid eligibility in your state by following the instructions at HealthCare.gov.
The government site is easy to use and after you have selected your state, it will navigate you to the appropriate contact point to make the application. State Medicaid programs may cover the full cost of your medication.
People who qualify for both Medicare and Medicaid are called ‘dual eligibles’.
If you are denied Medicaid for estradiol/levonorgestrel, and you are still unable to afford your copay or co-insurance element (for example if you are in the coverage gap or Donut Hole) then you may be eligible for a federal support program like Low Income Subsidy. To be eligible for Low Income Subsidy, you need to be a resident in one of the 50 States or the District of Columbia. You can check eligibility online at SSA Medicare D Extra Help. You can also call Social Security at 1-800-772-1213 (TTY 1-800-325-0778).
I am uninsured or underinsured and none of the estradiol/levonorgestrel prescription saving options are applicable or affordable for me, what can I do?
If you are uninsured or underinsured (for example, estradiol/levonorgestrel is not covered by your plan) and the drug savings options are not applicable or still unaffordable, then you can check Medicaid eligibility in your state by following the instructions at HealthCare.gov.
The government site is easy to use and you can select your state and it will navigate you to the appropriate contact point to make the application. State Medicaid programs may cover the full cost of your medication.
If you are denied and all else fails, and if you have been prescribed estradiol/levonorgestrel for an FDA-approved indication, you can call the pharmaceutical company to see if they have any other assistance programs.
I am commercially or privately insured and none of the estradiol/levonorgestrel prescription saving options are applicable or affordable for me, what can I do?
If your medication is not covered by your plan, you can appeal your insurance company’s decision. Sometimes, a formal appeal can result in the drug being covered if it is deemed medically necessary.
If you cannot afford your copay contribution, then you can check Medicaid eligibility in your state by following the instructions at HealthCare.gov.
However, being privately insured might complicate your eligibility for Medicaid, as having private insurance may be considered in the financial eligibility assessment.
The government site is easy to use and you can select your state and it will navigate you to the appropriate contact point to make the application. If you qualify, state Medicaid may cover the full cost of your medication.
If I have federal, state or commercial insurance and none of the estradiol/levonorgestrel prescription saving options are applicable or affordable for me, are there any other support organisations that can help me with my co-insurance or copay contributions?
If you have already tried Medicaid and received a denial letter or if you are insured with Medicare and have been denied Low-Income Subsidy, then you can try one of the following organizational support programs:
1. Patient Access Network Foundation (PAN) assistance for estradiol/levonorgestrel
If you are having trouble paying for your estradiol/levonorgestrel medication due to unaffordable copays or deductibles, the Patient Access Network Foundation (PAN), may be able to assist you. To qualify for PAN assistance for estradiol/levonorgestrel you will need to meet one or all of the following criteria:
- Your income is below 400% of the federal poverty level
- estradiol/levonorgestrel is prescribed for an approved FDA indication
- You live in and receive treatment in the United States or U.S. territories, even if you do not have U.S. citizenship
- You have Medicare insurance coverage that covers estradiol/levonorgestrel
- If estradiol/levonorgestrel is listed on PAN’s list of covered medications
You can check the Patient Access Network Foundation Website for more information.
2. HealthWell Foundation Copay Program for estradiol/levonorgestrel
If you are having trouble paying for your estradiol/levonorgestrel medication due to unaffordable copays or deductibles, the HealthWell Foundation Copay Program may be able to assist you. To qualify for assistance for estradiol/levonorgestrel you will need to meet the following criteria:
- You live in and are being treated in the United States
- You are insured and your plan covers estradiol/levonorgestrel
- If estradiol/levonorgestrel is listed on the HealthWell Foundation’s list of covered medications
You can check the HealthWell Foundation Website for more information.
3. Patient Advocate Foundation Co-Pay Relief Program for estradiol/levonorgestrel
Patient Advocate Foundation’s Co-Pay Relief program exists to help reduce the financial distress you or your family may face when paying for your estradiol/levonorgestrel treatment. If you qualify and can demonstrate the need, the foundation will provide you with direct payment covering co-pays, co-insurance, and deductibles. To qualify for assistance for estradiol/levonorgestrel you will need to meet the following criteria:
- You must be currently insured and have coverage for estradiol/levonorgestrel
- You must have a confirmed diagnosis and treatment plan
- You must reside and receive treatment in the United States
- Your Income must fall at or below 300% or 400% of the Federal Poverty Guideline (FPG) with consideration for the Cost of Living Index (COLI) and number in the household
- Applications can also be completed by contacting the program sponsor, toll-free at 866-512-3861.
You can check the Patient Advocate Foundation Website for more information.
Medical Disclaimer
NowPatient has taken all reasonable steps to ensure that all material is factually accurate, complete, and current. However, the knowledge and experience of a qualified healthcare professional should always be sought after instead of using the information on this page. Before taking any drug, you should always speak to your doctor or another qualified healthcare provider.
The information provided here about medications is subject to change and is not meant to include all uses, precautions, warnings, directions, drug interactions, allergic reactions, or negative effects. The absence of warnings or other information for a particular medication does not imply that the medication or medication combination is appropriate for all patients or for all possible purposes.
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You can lower the cost of your prescription medications using our various savings programs which include drug coupons, savings card and manufacturer-sponsored patient assistance programs.
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