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Erivedge is the brand name for vismodegib oral capsules.

Erivedge is available as a 150 mg oral capsule.

Erivedge is a hedgehog pathway inhibitor that is used to treat basal cell carcinoma that has spread to other parts of the body (metastatic) or that can’t be removed by surgery.

Erivedge is a Hedgehog pathway inhibitor, meaning it blocks the Hedgehog pathway. It treats skin cancer by turning this pathway off so that the cancer cells can’t grow or spread as well.

The usual dose is 150 mg by mouth once a day.

Erivedge is a safe and effective treatment when used for FDA licensed indications. However, like all medications, they may give you unwanted side effects. You should always discuss potential side effects with your physician to ensure the medication is suitable and right for you.

Common side effects of Erivedge:

• Muscle spasms
• Hair loss
• Taste changes
• Weight loss
• Tiredness
• Nausea
• Diarrhea
• Lower appetite
• Constipation
• Joint pain

Serious side effects are rare with Erivedge. Contact your healthcare provider immediately if you experience any of the following.

• Serious skin reactions: painful blisters, skin wounds, peeling skin, fever, sore throat, body aches

• There are no major drug interactions listed for Erivedge. However, always let your physician and pharmacist know about any other medications or supplements (including prescribed and over-the-counter medications, vitamins, and dietary or herbal supplements) that you are currently taking

Genentech, Inc.

Erivedge can cause your baby to die before it is born (be stillborn) or cause your baby to have severe birth
defects. For females who can become pregnant:
Your healthcare provider will do a pregnancy test within 7 days before you start taking Erivedge. In order to avoid pregnancy, you should use birth control during treatment and for 24 months after your final dose of Erivedge. Talk with your healthcare provider about what birth control method is right for you during this time. Tell your healthcare provider right away if you become pregnant or think that you may be pregnant.

For males:
Erivedge is present in semen. Do not donate semen while you are taking Erivedge and for 3 months after
your final dose.
You should always use a condom, even if you have had a vasectomy, during sex with female partners who are
pregnant or who are able to become pregnant, during treatment with Erivedge and for 3 months after your final
dose to protect your female partner from being exposed to Erivedge. Tell your healthcare provider right away if your partner becomes pregnant or thinks she is pregnant while you are taking Erivedge. Pregnancy Exposure Registry:
There is a Pregnancy Exposure Registry for females taking Erivedge who become pregnant. The purpose of this
registry is to monitor the health of you and your unborn baby. If you think that you or your female partner may have
been exposed to Erivedge during pregnancy, talk to your healthcare provider right away. If you become pregnant
during treatment with Erivedge, you or your healthcare provider should report your pregnancy to Genentech at 1-888-835-2555.

• Vismodegib