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Empagliflozin is available as a 10 mg and 25 mg oral tablet.

Empagliflozin is a SGLT2 inhibitor and is used for the following:

• Type 2 diabetes in people age 10 years and older
• Lowering the risk of death due to heart problems in adults with Type 2 diabetes and heart disease
• Lowering the risk of hospitalization and death due to heart problems in adults with heart failure
• Lowering the risk of worsening kidney problems, hospitalization, and death due to heart problems in adults with CKD

Empagliflozin is a sodium-glucose cotransporter 2 (SGLT2) inhibitor. It works in the kidneys to prevent sugar and sodium (salt) from absorbing back into your body. For Type 2 diabetes: It lowers blood sugar by causing your body to get rid of excess sugar through your urine. For heart failure and CKD: By preventing sodium reabsorption, the heart fills with blood easier and pumps blood more easily throughout the body. This might also improve blood flow through the kidneys and lower the stress on these organs to help slow the worsening of CKD.

• Empagliflozin is typically started at 10 mg by mouth once daily in the morning
• For Type 2 diabetes, your provider might raise your dose to 25 mg once daily depending on how well the medication is working for you

Empagliflozin is a safe and effective treatment when used for FDA licensed indications. However, like all medications, they may give you unwanted side effects. You should always discuss potential side effects with your physician to ensure the medication is suitable and right for you. You should not use this medication if you have a hypersensitivity to Empagliflozin or any of the excipients in Empagliflozin.

Common side effects of Empagliflozin:

• Urinary tract infections
• Vaginal yeast infection in females
• Upper respiratory tract infection
• High cholesterol or fat levels in your blood
• Urinating more than usual

Serious side effects are rare with Empagliflozin. Contact your healthcare provider immediately if you experience any of the following.

• Severe allergic reaction: swelling in the face, throat, tongue, or mouth; rash; trouble breathing
• High ketone levels in the blood: nausea, vomiting, stomach pain, tiredness, thirsty, dry mouth, fruity breath, trouble breathing

The following medications may interact with Empagliflozin:

• Coadministration of Empagliflozin with diuretics resulted in increased urine volume and frequency of voids, which might enhance the potential for volume depletion
• The risk of hypoglycemia is increased when Empagliflozin is used in combination with insulin secretagogues (e.g., sulfonylurea) or insulin
• Concomitant use of an SGLT2 inhibitor with lithium may decrease serum lithium concentrations

Various FDA-approved generic manufacturers

Based on animal data showing adverse renal effects, Empagliflozin is not recommended during the second and
third trimesters of pregnancy.

• Jardiance