DUAVEE
Used for Menopause
NowPatient helps you obtain your DUAVEE prescription for free or at low-cost. Drug savings programs are suitable for individuals who are insured, don't have insurance or are underinsured and can't afford your medicine.
Manufactured by Pfizer
*You can pay as little as $0 per fill using Drug Coupons or Patient Assistance Programs. Subject to applicability & eligibility requirements.
This content is intended for US audiences only
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DUAVEE key facts
What is DUAVEE?
DUAVEE is the brand name for conjugated estrogens/bazedoxifene and is available as an oral tablet.
What dosages is DUAVEE available in?
DUAVEE is available as an oral tablet containing conjugated estrogens 0.45 mg and bazedoxifene 20 mg.
What is DUAVEE used for?
DUAVEE is an estrogen replacement / SERM and is used for the following:
- Hot flashes and night sweats during menopause
- Prevention of osteoporosis in women who have gone through menopause
How does DUAVEE work?
DUAVEE is a combination of two medications that help boost estrogen effects in the body. Conjugated estrogens is a mixture of estrogens that replace the natural hormone your body loses during menopause. This loss of estrogen during menopause causes hot flashes and night sweats. Bazedoxifene is a selective estrogen receptor modulator (SERM). It has opposite effects depending on where it works in the body. In bone, bazedoxifene acts like estrogen to prevent bone breakdown and improve bone mineral density (BMD), which is a measure of how dense and strong your bones are. This helps lower your risk of bone fractures. In the uterus, bazedoxifene stops estrogen from causing overgrowth of the uterus lining, which helps lower the risk of uterine cancer. By working together, conjugated estrogens and bazedoxifene help to relieve menopause symptoms and prevent osteoporosis while lowering the risk of uterine cancer.
How do I take DUAVEE?
DUAVEE is typically dosed as 1 tablet by mouth once daily. Each tablet contains 0.45 mg of conjugated estrogens and 20 mg of bazedoxifene.
Is it safe for me to take DUAVEE?
DUAVEE is a safe and effective treatment when used for FDA licensed indications. However, like all medications, they may give you unwanted side effects. You should always discuss potential side effects with your physician to ensure the medication is suitable and right for you. You should not use this medication in the following:
- Undiagnosed abnormal uterine bleeding
- Known, suspected, or past history of breast cancer
- Known or suspected estrogen-dependent neoplasia
- Active or past history of venous thromboembolism
- Active or past history of arterial thromboembolism
- Hypersensitivity (angioedema, anaphylaxis) to estrogens, bazedoxifene, or any ingredients
- Known hepatic impairment or disease
- Known protein C, protein S, or antithrombin deficiency or other known thrombophilic disorders
- Pregnancy
DUAVEE Common Side Effects
Common side effects of DUAVEE:
- Muscle spasms or twitching
- Nausea
- Diarrhea
- Heartburn
- Upper stomach pain
- Throat pain
- Dizziness
- Neck pain
DUAVEE Serious Side Effects
Serious side effects are rare with DUAVEE. Contact your healthcare provider immediately if you experience any of the following.
- Blood clots: leg pain or swelling, skin that’s warm to the touch, trouble breathing
- Stroke: sudden weakness on one side of your body, headache, changes in your speech or vision, confusion
Unusual vaginal bleeding
Effects of other drugs, drug classes and over-the-counter products on DUAVEE
The following medications may interact with DUAVEE:
- Cytochrome P450 (CYP): Inducers of CYP3A4, such as St. John’s Wort (Hypericum perforatum) preparations, phenobarbital, carbamazepine, and rifampin, may reduce plasma concentrations of some estrogens, possibly resulting in a decrease in therapeutic effects and/or changes in the uterine bleeding profile
- Uridine Diphosphate Glucuronosyltransferase (UGT): The metabolism of bazedoxifene may be increased by concomitant use of substances known to induce UGTs, such as rifampin, phenobarbital, carbamazepine, and phenytoin. A reduction in bazedoxifene exposure may be associated with an increase risk of endometrial hyperplasia. Adequate diagnostic measures, including directed or random endometrial sampling when indicated, should be undertaken to rule out malignancy in postmenopausal women with undiagnosed persistent or recurring abnormal genital bleeding
- Atorvastatin: Concomitant administration of bazedoxifene (40 mg daily) and atorvastatin (20 mg, single-dose) to healthy postmenopausal women did not affect the pharmacokinetics of bazedoxifene, atorvastatin or its active metabolites
Who makes DUAVEE?
Pfizer
Is DUAVEE safe in pregnancy?
DUAVEE is contraindicated for use in pregnant women and is not indicated for use in females of reproductive potential. If you think you may be pregnant, you should have a pregnancy test and know the results. Do not take DUAVEE if the test is positive and talk to your healthcare provider.
The FDA's medical product safety reporting program for health professionals, patients and consumers.
Learn more about reporting side effects in the USDrug Savings Guide
A practical guide to saving money and receiving support with prescription costs
How can NowPatient help me to lower the cost of my DUAVEE prescription?
After you create a FREE account with NowPatient, you will have access to 4 programs that can help lower the cost of your DUAVEE prescription
Applicability to each program will be dependent on your insurance status.
How do the NowPatient DUAVEE savings programs work?
After you have created your FREE account with NowPatient, you can access the various programs from your account dashboard. Each program has clear instructions on how to check your eligibility. You can see how the process works by clicking on the feature link below and seeing the ‘How it works’ steps.
Drug Coupon and Patient Assistance Programs require an eligibility quiz to be completed.
Are the NowPatient DUAVEE savings programs suitable for everyone, regardless of insurance status?
No. Each program has its own eligibility and applicability requirements. The table below shows if a program is available to you, based on your insurance status.
| Rx Advantage Card* for DUAVEE | Canadian Prescription Savings* for DUAVEE | DUAVEE Drug Coupon* | DUAVEE Patient Assistance Program* | |
| Insured (federal, state or government) | Available | Available | Not Available | Available If Offered by Pharmaceutical Company |
| Insured (Commercial or Private) | Available | Available | Available If Offered by Pharmaceutical Company | Available If Offered by Pharmaceutical Company |
| Uninsured | Available | Available | Not Available | Available If Offered by Pharmaceutical Company |
| Insured but without pharmacy benefit or drug coverage | Available | Available | Not Available | Available If Offered by Pharmaceutical Company |
*This is not insurance.
Are the NowPatient drug savings programs suitable for brand and generic versions of DUAVEE?
No. Each program has applicability requirements. Please see below
| Rx Advantage Card* for DUAVEE | Canadian Prescription Savings* for DUAVEE | DUAVEE Drug Coupon* | DUAVEE Patient Assistance Program* | |
| Brand | Yes | Yes | Yes, If Offered by Pharmaceutical Company | Yes, If Offered by Pharmaceutical Company |
| Generic | Yes | Yes | No | No |
*This is not insurance.
If you have Medicare Part D or Medicare Advantage and none of the DUAVEE savings options are applicable or affordable for me, what can you do?
If you are insured with Medicare and the DUAVEE drug savings options are not applicable to you and still remain unaffordable, then you can check Medicaid eligibility in your state by following the instructions at HealthCare.gov.
The government site is easy to use and after you have selected your state, it will navigate you to the appropriate contact point to make the application. State Medicaid programs may cover the full cost of your medication.
People who qualify for both Medicare and Medicaid are called ‘dual eligibles’.
If you are denied Medicaid for DUAVEE, and you are still unable to afford your copay or co-insurance element (for example if you are in the coverage gap or Donut Hole) then you may be eligible for a federal support program like Low Income Subsidy. To be eligible for Low Income Subsidy, you need to be a resident in one of the 50 States or the District of Columbia. You can check eligibility online at SSA Medicare D Extra Help. You can also call Social Security at 1-800-772-1213 (TTY 1-800-325-0778).
I am uninsured or underinsured and none of the DUAVEE prescription saving options are applicable or affordable for me, what can I do?
If you are uninsured or underinsured (for example, DUAVEE is not covered by your plan) and the drug savings options are not applicable or still unaffordable, then you can check Medicaid eligibility in your state by following the instructions at HealthCare.gov.
The government site is easy to use and you can select your state and it will navigate you to the appropriate contact point to make the application. State Medicaid programs may cover the full cost of your medication.
If you are denied and all else fails, and if you have been prescribed DUAVEE for an FDA-approved indication, you can call the pharmaceutical company to see if they have any other assistance programs.
I am commercially or privately insured and none of the DUAVEE prescription saving options are applicable or affordable for me, what can I do?
If your medication is not covered by your plan, you can you can appeal your insurance company’s decision. Sometimes, a formal appeal can result in the drug being covered if it is deemed medically necessary.
If you cannot afford your copay, then you can check Medicaid eligibility in your state by following the instructions at HealthCare.gov.
However, being privately insured might complicate your eligibility for Medicaid, as having private insurance may be considered in the financial eligibility assessment.
The government site is easy to use and you can select your state and it will navigate you to the appropriate contact point to make the application. If you qualify, state Medicaid may cover the full cost of your medication.
If I have federal, state or commercial insurance and none of the DUAVEE prescription saving options are applicable or affordable for me, are there any other support organisations that can help me with my co-insurance or copay?
If you have already tried Medicaid and received a denial letter or if you are insured with Medicare and have been denied Low-Income Subsidy, then you can try one of the following organizational support programs:
1. Patient Access Network Foundation (PAN) assistance for DUAVEE
If you are having trouble paying for your DUAVEE medication due to unaffordable copays or deductibles, the Patient Access Network Foundation (PAN), may be able to assist you. To qualify for PAN assistance for DUAVEE you will need to meet one or all of the following criteria:
- Your income is below 400% of the federal poverty level
- DUAVEE is prescribed for an approved FDA indication
- You live in and receive treatment in the United States or U.S. territories, even if you do not have U.S. citizenship
- You have Medicare insurance coverage that covers DUAVEE
- If DUAVEE is listed on PAN’s list of covered medications
You can check the Patient Access Network Foundation Website for more information.
2. HealthWell Foundation Copay Program for DUAVEE
If you are having trouble paying for your DUAVEE medication due to unaffordable copays or deductibles, the HealthWell Foundation Copay Program may be able to assist you. To qualify for assistance for DUAVEE you will need to meet the following criteria:
- You live in and are being treated in the United States
- You are insured and your plan covers DUAVEE
- If DUAVEE is listed on the HealthWell Foundation’s list of covered medications
You can check the HealthWell Foundation Website for more information.
3. Patient Advocate Foundation Co-Pay Relief Program for DUAVEE
Patient Advocate Foundation’s Co-Pay Relief program exists to help reduce the financial distress you or your family may face when paying for your DUAVEE treatment. If you qualify and can demonstrate the need, the foundation will provide you with direct payment covering co-pays, co-insurance, and deductibles. To qualify for assistance for DUAVEE you will need to meet the following criteria:
- You must be currently insured and have coverage for DUAVEE
- You must have a confirmed diagnosis and treatment plan
- You must reside and receive treatment in the United States
- Your Income must fall at or below 300% or 400% of the Federal Poverty Guideline (FPG) with consideration for the Cost of Living Index (COLI) and number in the household
- Applications can also be completed by contacting the program sponsor, toll-free at 866-512-3861.
You can check the Patient Advocate Foundation Website for more information.
Medical Disclaimer
NowPatient has taken all reasonable steps to ensure that all material is factually accurate, complete, and current. However, the knowledge and experience of a qualified healthcare professional should always be sought after instead of using the information on this page. Before taking any drug, you should always speak to your doctor or another qualified healthcare provider.
The information provided here about medications is subject to change and is not meant to include all uses, precautions, warnings, directions, drug interactions, allergic reactions, or negative effects. The absence of warnings or other information for a particular medication does not imply that the medication or medication combination is appropriate for all patients or for all possible purposes.
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