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Conjugated Estrogens/Bazedoxifene is available as an oral tablet containing conjugated estrogens 0.45 mg and bazedoxifene 20 mg.

Conjugated Estrogens/Bazedoxifene is an estrogen replacement / SERM and is used for the following:

• Hot flashes and night sweats during menopause
• Prevention of osteoporosis in women who have gone through menopause

Conjugated Estrogens/Bazedoxifene is a combination of two medications that help boost estrogen effects in the body. Conjugated estrogens is a mixture of estrogens that replace the natural hormone your body loses during menopause. This loss of estrogen during menopause causes hot flashes and night sweats. Bazedoxifene is a selective estrogen receptor modulator (SERM). It has opposite effects depending on where it works in the body. In bone, bazedoxifene acts like estrogen to prevent bone breakdown and improve bone mineral density (BMD), which is a measure of how dense and strong your bones are. This helps lower your risk of bone fractures. In the uterus, bazedoxifene stops estrogen from causing overgrowth of the uterus lining, which helps lower the risk of uterine cancer. By working together, conjugated estrogens and bazedoxifene help to relieve menopause symptoms and prevent osteoporosis while lowering the risk of uterine cancer.

Conjugated Estrogens/Bazedoxifene is typically dosed as 1 tablet by mouth once daily. Each tablet contains 0.45 mg of conjugated estrogens and 20 mg of bazedoxifene.

Conjugated Estrogens/Bazedoxifene is a safe and effective treatment when used for FDA licensed indications. However, like all medications, they may give you unwanted side effects. You should always discuss potential side effects with your physician to ensure the medication is suitable and right for you. You should not use this medication in the following:

• Undiagnosed abnormal uterine bleeding
• Known, suspected, or past history of breast cancer
• Known or suspected estrogen-dependent neoplasia
• Active or past history of venous thromboembolism
• Active or past history of arterial thromboembolism
• Hypersensitivity (angioedema, anaphylaxis) to estrogens, bazedoxifene, or any ingredients
• Known hepatic impairment or disease
• Known protein C, protein S, or antithrombin deficiency or other known thrombophilic disorders
• Pregnancy

Common side effects of Conjugated Estrogens/Bazedoxifene:

• Muscle spasms or twitching
• Nausea
• Diarrhea
• Heartburn
• Upper stomach pain
• Throat pain
• Dizziness
• Neck pain

Serious side effects are rare with Conjugated Estrogens/Bazedoxifene. Contact your healthcare provider immediately if you experience any of the following.

• Blood clots: leg pain or swelling, skin that’s warm to the touch, trouble breathing
• Stroke: sudden weakness on one side of your body, headache, changes in your speech or vision, confusion
  Unusual vaginal bleeding

The following medications may interact with Conjugated Estrogens/Bazedoxifene:

• Cytochrome P450 (CYP): Inducers of CYP3A4, such as St. John’s Wort (Hypericum perforatum) preparations, phenobarbital, carbamazepine, and rifampin, may reduce plasma concentrations of some estrogens, possibly resulting in a decrease in therapeutic effects and/or changes in the uterine bleeding profile
• Uridine Diphosphate Glucuronosyltransferase (UGT): The metabolism of bazedoxifene may be increased by concomitant use of substances known to induce UGTs, such as rifampin, phenobarbital, carbamazepine, and phenytoin. A reduction in bazedoxifene exposure may be associated with an increase risk of endometrial hyperplasia. Adequate diagnostic measures, including directed or random endometrial sampling when indicated, should be undertaken to rule out malignancy in postmenopausal women with undiagnosed persistent or recurring abnormal genital bleeding
• Atorvastatin: Concomitant administration of bazedoxifene (40 mg daily) and atorvastatin (20 mg, single-dose) to healthy postmenopausal women did not affect the pharmacokinetics of bazedoxifene, atorvastatin or its active metabolites

Various FDA-approved generic manufacturers

Conjugated Estrogens/Bazedoxifene is contraindicated for use in pregnant women and is not indicated for use in females of reproductive potential. If you think you may be pregnant, you should have a pregnancy test and know the results. Do not take Conjugated Estrogens/Bazedoxifene if the test is positive and talk to your healthcare provider.

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