DoxycyclinePrices, Coupons & Savings

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*Based on the difference between the U&C price submitted and the price the patient paid, as of April 2023.

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  1. Medication
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  2. Doxycycline Monohydrate
    Generic for Mondoxyne NL
    45 capsules $8.1 USD
    Save $51.30
  3. Doxycycline Hyclate
    Generic for Acticlate
    30 tablets $16.2 USD
    Save $827.10
  4. Doxycycline Hyclate
    Generic for Acticlate
    30 tablets $15.9 USD
    Save $827.40
  5. Doxycycline Monohydrate
    Generic for Adoxa
    30 tablets $13.2 USD
    Save $45.00
  6. Doxycycline Hyclate
    Generic for Vibramycin
    9 capsules $6.6 USD
    Save $4.74
  7. Doxycycline Hyclate
    Generic for Lymepak
    30 tablets $8.4 USD
    Save $101.40
  8. Doxycycline Monohydrate
    Generic for Adoxa
    12 tablets $6.9 USD
    Save $16.38
  9. Doxycycline Monohydrate
    Generic for Mondoxyne NL
    30 capsules $6 USD
    Save $33.60
  10. Doxycycline Monohydrate
    Generic for Adoxa
    30 tablets $13.2 USD
    Save $45.00
  11. Doxycycline Hyclate
    Generic for Vibramycin
    30 tablets $17.4 USD
    Save $20.40
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Do you need a prescription for doxycycline?

Yes, doxycycline is only available with a valid physician Rx.

How much is doxycycline without Insurance in the US?

Our website gives two competitive savings options to US customers who wish to purchase doxycycline, as either a brand or generic, if available. The first is access to medications through our mail-order online pharmacy. The second is by using the Now Patient Rx Advantage Card, which can be used in over 65,000 pharmacies nationwide, across America. If you are insured, then in most cases, the cash price will be significantly cheaper than the copay.

What will my out-of-pocket cost be for doxycycline in the US?

There are no out-of-pocket (OOP) costs because we are currently only offering a cash-based option to purchase medications.

Is Now Patient a doxycycline savings card?

Yes. Save up to 90% on your doxycycline with the FREE Now Patient Rx Advantage card*.
*Based on the difference between the U&C submitted by the pharmacy and the price the patients pay.

Can you handle Rx transfers for home delivery in the US?

Yes. If you use the mail-order online pharmacy option, then we can handle requests by you to have your prescription transferred to our pharmacy for home delivery. We can even help you manage your refills by giving you timely reminders, so you do not run out of your medication.

Is Now Patient a doxycycline coupon provider in the US?

No. Now Patient does not provide doxycycline coupons or FREE doxycycline samples.

Do you accept commercial, Medicare or Medicaid coverage for doxycycline in the US?

No. Currently, we only offer cash-based options for purchase, therefore we do not require your insurance benefit details. In the future, our plan is to be able to handle commercial insurance, Medicare and Medicaid including cases where you have multiple health plans that provide benefit coverage (e.g. Medicaid and Commercial). We also anticipate being able to handle more complex scenarios such as using primary insurance combined with a manufacturer copay assistance program.

Does Now Patient work with Medicare?

Our cash-based prices for medications are typically cheaper than Medicare copays. We do not bill Medicare Part D (standalone drug coverage) or Medicare Advantage (combined health and drug coverage). When you purchase your medication from Now Patient, you will be doing so out of your pocket. The spend will not count towards your plan deductibles or gaps.

Does Now Patient work with Commercial Insurance?

Our cash-based prices for medications are typically cheaper than commercial plan copays. We do not bill your commercial plan. When you purchase your medication from Now Patient, you will be doing so out of your pocket. The spend will not count towards your plan deductibles or gaps.

What should you do if you use too much doxycycline?


Call your doctor right away or seek immediate medical attention if your symptoms do not improve or they become worse after using doxycycline. You can also call 800-222-1222 to reach the American Association of Poison Control Centers or use its online resource if you think you’ve used too much doxycycline. But if you have severe symptoms, call 911 (or your local emergency number) immediately or go to the nearest emergency room.


If you think it is an emergency, call 999 or find your nearest A&E
If you need help now, but it’s not an emergency go to 111.nhs.uk or call 111. Alternatively you can speak to one of our pharmacists or use the Now Patient app to make an appointment with your GP.

What should I do if I miss my dose?

There are occasions when people forget to take their medication at correct prescribed times. This may not only have an effect on potentially making the medication less effective but it may also inadvertently lead to taking doses too close together, thereby increasing the risks of side effects.

Click here to find out what to do if you forgot to take your medication

What is generic doxycycline?

Generic doxycycline refers to the non-brand-name version of the medication. It contains the same active ingredient as the brand-name drug but is typically less expensive.

FDA approval of doxycycline

Doxycycline is approved by the U.S. Food and Drug Administration (FDA) for the treatment of various bacterial infections.

Active ingredient of doxycycline

The active ingredient of doxycycline is doxycycline hyclate.

US brand name of doxycycline and manufacturer

Doxycycline is available as a generic medication in the US, and it is manufactured by multiple pharmaceutical companies.

UK brand name of doxycycline and manufacturer

In the UK, doxycycline is available under various brand names, and the manufacturers may vary.

Prescription requirement for doxycycline

A prescription (Rx) is required for doxycycline in both the US and the UK.

Availability of doxycycline in the UK with NHS prescription

Doxycycline is available in the UK with an NHS prescription.

Conditions treated by doxycycline

  • Doxycycline is effective against various bacterial infections, including respiratory tract infections, urinary tract infections, skin and soft tissue infections, eye infections, and sexually transmitted infections like chlamydia, gonorrhea, and syphilis
  • Doxycycline is often prescribed to treat moderate to severe acne. It helps to reduce inflammation and control the growth of bacteria on the skin, leading to improvements in acne symptoms
  • Rosacea is a chronic skin condition characterized by facial redness, bumps, and flushing. Doxycycline is commonly prescribed to manage the symptoms of rosacea by reducing inflammation and controlling the growth of bacteria on the skin
  • Doxycycline is one of the medications used for malaria prophylaxis (prevention) in areas where the malaria parasite is resistant to other drugs. It can also be used as a treatment for malaria, particularly in combination with other antimalarial medications
  • Doxycycline is the most commonly prescribed antibiotic for the treatment of early-stage Lyme disease. It is highly effective in killing the bacteria that cause Lyme disease and can prevent the progression of the infection to more severe stages
  • Doxycycline is one of the antibiotics used for the treatment and prevention of anthrax. It is effective in killing the bacteria that cause anthrax and can be used both in the early stages of the infection and as a preventative measure for those at risk
  • Doxycycline is the drug of choice for the treatment of Rocky Mountain spotted fever, a tick-borne infection. It effectively kills the bacteria responsible for the disease and helps alleviate symptoms

How does doxycycline work?

Doxycycline belongs to a class of medications called tetracycline antibiotics. It works by inhibiting the growth and reproduction of bacteria by interfering with their protein synthesis. This helps to eliminate the infection and relieve associated symptoms.

Forms of doxycycline available

Doxycycline comes as a capsule, tablet, delayed-release tablet, and suspension (liquid) to take by mouth.

Dosage of doxycycline

The dosage of doxycycline depends on the specific condition being treated, the severity of the infection, and individual patient factors. It is important to follow the prescribed dosage and drug information provided by the healthcare provider.

If you miss a dose, take it as soon as you remember. If it is near the time of the next dose, skip the missed dose. Take your next dose at the regular time. Do not double the dose to catch up.

Directions for doxycycline use

Doxycycline should be taken as directed by the healthcare provider. The tablets or capsules should be taken with a full glass of water and swallowed whole. Taking it with food or milk can help reduce the risk of stomach upset.

Store at room temperature away from moisture, heat, light and reach of children.

Warnings and precautions for doxycycline

  • Using doxycycline in children under the age of 8 or during tooth development may cause permanent tooth discoloration
  • It may cause photosensitivity reactions, so it’s important to protect the skin from excessive sunlight or artificial UV light during treatment. Doxycycline can make you sunburn more easily. Wear protective clothing and use sunscreen (SPF 30 or higher) when you are outdoors. Tell your doctor right away if you get sunburned or have skin blisters/redness

Drug interactions for doxycycline

Doxycycline may interact with certain medications:

  • It is recommended to avoid taking antacids, calcium, magnesium or iron supplements within 2 hours before or after taking doxycycline to ensure optimal absorption. These can reduce the absorption of doxycycline in the body
  • Taking doxycycline with retinoids, such as isotretinoin (Accutane), can increase the risk of intracranial hypertension, a condition characterized by increased pressure within the skull. This combination should be avoided to prevent this serious side effect
  • Combining doxycycline with penicillin antibiotics may reduce the effectiveness of each drug. These antibiotics work through different mechanisms, and their combination may interfere with each other’s actions. If both medications are required, your doctor may need to adjust the doses or prescribe an alternative
  • Doxycycline can interact with warfarin, an anticoagulant (blood thinner), and increase the risk of bleeding. If you are taking warfarin, your doctor may need to monitor your blood clotting more closely and adjust the dose of warfarin if necessary

It is important to inform your healthcare provider about all the medications you are taking, including prescription drugs, over-the-counter, and herbal products, before starting doxycycline. They can determine if any of these medications may interact with doxycycline and recommend appropriate alternatives or adjustments.

Use of doxycycline during pregnancy

Doxycycline should be avoided during pregnancy, particularly during the second and third trimesters, as it can interfere with fetal bone development and cause other adverse effects. Consultation with a healthcare provider is necessary to weigh the potential risks and benefits.

Use of doxycycline while breastfeeding

Doxycycline may pass into breast milk and may affect the nursing infant’s developing teeth and bones. It is generally recommended to avoid doxycycline while breastfeeding. Consultation with a healthcare provider is necessary to discuss alternative treatment options.

Possible side effects of doxycycline

Common side effects:

  • Nausea and stomach upset
  • Diarrhea
  • Headache
  • Loss of appetite

Serious Side Effects:

While doxycycline is generally safe and well-tolerated, there are some serious side effects that can occur with its use. It’s important to be aware of these potential risks before starting this medication.

  • In rare cases, doxycycline can cause an allergic reaction characterized by hives, skin rash, difficulty breathing, and swelling of the face or throat. Seek immediate medical attention if you experience any of these symptoms
  • A rare but serious side effect of doxycycline is intracranial hypertension. This condition causes increased pressure within the skull leading to severe headaches and visual disturbances. If you experience any changes in vision or persistent headaches while taking this medication, contact your healthcare provider immediately

Similar drugs to doxycycline

Other tetracycline antibiotics similar to doxycycline include tetracycline and minocycline.



Now Patient has taken all reasonable steps to ensure that all material is factually accurate, complete, and current. However, the knowledge and experience of a qualified healthcare professional should always be sought after instead of using the information in this page. Before taking any drug, you should always speak to your doctor or another qualified healthcare provider.

The information provided here about medications is subject to change and is not meant to include all uses, precautions, warnings, directions, drug interactions, allergic reactions, or negative effects. The absence of warnings or other information for a particular medication does not imply that the medication or medication combination is appropriate for all patients or for all possible purposes.

About Now Patient

Now Patient’s online services are available in the US and UK. We help you manage your prescriptions, doctor appointments, test results, health risks, and a lot more, all in one place for FREE. If you are in the United States, you could enjoy savings using Now Patient’s mail-order pharmacy or use the Now Patient Rx Advantage Card at over 65,000 pharmacies, with savings of up to 90% on popular FDA-approved brand and generic medications like Ozempic, Mounjaro, clopidogrel and lots more. We do not currently handle commercial insurance, Medicare or Medicaid. UK NHS and private prescriptions are delivered FREE of charge across England & Wales by our UK NHS online pharmacy.

Stefano Mirabello Medical Reviewer
Pharmacist / B.Pharm
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