DesvenlafaxinePrices, Coupons & Savings

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*Based on the difference between the U&C price submitted and the price the patient paid, as of April 2023.

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  2. Desvenlafaxine Succinate Extended Release (ER)
    Generic for Pristiq
    34 extended release tablets $20.4 USD
    Save $307.70
  3. Desvenlafaxine Succinate Extended Release (ER)
    Generic for Pristiq
    17 extended release tablets $11.4 USD
    Save $152.65
  4. Desvenlafaxine Succinate Extended Release (ER)
    Generic for Pristiq
    30 extended release tablets $18.3 USD
    Save $271.20
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Do you need a prescription for desvenlafaxine?

Yes, desvenlafaxine is only available with a valid physician Rx.

How much is desvenlafaxine without Insurance in the US?

Our website gives two competitive savings options to US customers who wish to purchase desvenlafaxine, as either a brand or generic, if available. The first is access to medications through our mail-order online pharmacy. The second is by using the Now Patient Rx Advantage Card, which can be used in over 65,000 pharmacies nationwide, across America. If you are insured, then in most cases, the cash price will be significantly cheaper than the copay.

What will my out-of-pocket cost be for desvenlafaxine in the US?

There are no out-of-pocket (OOP) costs because we are currently only offering a cash-based option to purchase medications.

Is Now Patient a desvenlafaxine savings card?

Yes. Save up to 90% on your desvenlafaxine with the FREE Now Patient Rx Advantage card*.
*Based on the difference between the U&C submitted by the pharmacy and the price the patients pay.

Can you handle Rx transfers for home delivery in the US?

Yes. If you use the mail-order online pharmacy option, then we can handle requests by you to have your prescription transferred to our pharmacy for home delivery. We can even help you manage your refills by giving you timely reminders, so you do not run out of your medication.

Is Now Patient a desvenlafaxine coupon provider in the US?

No. Now Patient does not provide desvenlafaxine coupons or FREE desvenlafaxine samples.

Do you accept commercial, Medicare or Medicaid coverage for desvenlafaxine in the US?

No. Currently, we only offer cash-based options for purchase, therefore we do not require your insurance benefit details. In the future, our plan is to be able to handle commercial insurance, Medicare and Medicaid including cases where you have multiple health plans that provide benefit coverage (e.g. Medicaid and Commercial). We also anticipate being able to handle more complex scenarios such as using primary insurance combined with a manufacturer copay assistance program.

Does Now Patient work with Medicare?

Our cash-based prices for medications are typically cheaper than Medicare copays. We do not bill Medicare Part D (standalone drug coverage) or Medicare Advantage (combined health and drug coverage). When you purchase your medication from Now Patient, you will be doing so out of your pocket. The spend will not count towards your plan deductibles or gaps.

Does Now Patient work with Commercial Insurance?

Our cash-based prices for medications are typically cheaper than commercial plan copays. We do not bill your commercial plan. When you purchase your medication from Now Patient, you will be doing so out of your pocket. The spend will not count towards your plan deductibles or gaps.

What should you do if you use too much desvenlafaxine?


Call your doctor right away or seek immediate medical attention if your symptoms do not improve or they become worse after using desvenlafaxine. You can also call 800-222-1222 to reach the American Association of Poison Control Centers or use its online resource if you think you’ve used too much desvenlafaxine. But if you have severe symptoms, call 911 (or your local emergency number) immediately or go to the nearest emergency room.


If you think it is an emergency, call 999 or find your nearest A&E
If you need help now, but it’s not an emergency go to 111.nhs.uk or call 111. Alternatively you can speak to one of our pharmacists or use the Now Patient app to make an appointment with your GP.

What should I do if I miss my dose?

There are occasions when people forget to take their medication at correct prescribed times. This may not only have an effect on potentially making the medication less effective but it may also inadvertently lead to taking doses too close together, thereby increasing the risks of side effects.

Click here to find out what to do if you forgot to take your medication

US brand name of desvenlafaxine and manufacturer

Desvenlafaxine is available in the US under the brand name Pristiq. It is manufactured by Pfizer Inc.

UK brand name of desvenlafaxine and manufacturer

Desvenlafaxine is not currently available in the UK.

Prescription requirement for desvenlafaxine

Desvenlafaxine is a prescription medication and requires a prescription from a healthcare provider.

FDA approval of desvenlafaxine

Desvenlafaxine has received FDA approval for the treatment of major depressive disorder (MDD) in adults.

Active ingredient of desvenlafaxine and mechanism of action

The active ingredient in desvenlafaxine is desvenlafaxine succinate. It is a serotonin-norepinephrine reuptake inhibitor (SNRI) that works by increasing the levels of serotonin and norepinephrine, two neurotransmitters in the brain associated with mood regulation.

Uses of desvenlafaxine

Desvenlafaxine is primarily used for the treatment of major depressive disorder (MDD) in adults. It helps improve mood, reduce feelings of sadness, and increase energy levels.

Forms of desvenlafaxine

Desvenlafaxine is available in the form of extended-release tablets.

Dosage of desvenlafaxine

The recommended dosage of desvenlafaxine for the treatment of major depressive disorder (MDD) is usually started at 50 mg once daily, with or without food. The dosage may be adjusted based on the individual’s response and tolerability. It is important to follow the dosage instructions provided by your healthcare provider. Swallow the tablets whole with plenty of water; do not split, chew, crush, or dissolve them.
If a patient misses a dose of desvenlafaxine, they should take it as soon as they remember. However, if it is close to the time for their next dose, they should skip the missed dose and continue with their regular dosing schedule. It is important not to double up on doses to make up for a missed one.
Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light.

Precautions and warnings for desvenlafaxine

  • Inform your healthcare provider about any medical conditions, especially if you have a history of seizures, bipolar disorder, or liver or kidney problems
  • When taking desvenlafaxine, it is important to be aware of the increased risk of experiencing suicidal thoughts or behavior. Antidepressants increased the risk of suicidal thinking and behavior (suicidality) in short-term studies in children and young adults with depression and other psychiatric disorders. If you notice any sudden changes in mood or become more depressed while on this medication, seek immediate medical advice. Remember that reaching out for support is crucial during this time
  • Be mindful of your blood pressure while taking desvenlafaxine to avoid any potential risks or complications. If you already have high blood pressure, talk with your doctor. Regularly monitor your blood pressure levels and consult with a healthcare professional if you notice any significant changes or elevations
  • Desvenlafaxine is very similar to venlafaxine. Do not use medications containing venlafaxine while using desvenlafaxine
  • It may take several weeks for the full effects of desvenlafaxine to be felt. Do not stop taking the medication abruptly without consulting your healthcare provider
  • Desvenlafaxine may cause drowsiness or dizziness. Avoid driving or operating machinery until you know how the medication affects you
  • If you are pregnant, planning to become pregnant, or breastfeeding, discuss the potential risks and benefits of desvenlafaxine with your healthcare provider

Side effects of desvenlafaxine

Common side effects of desvenlafaxine may include:

  • Nausea
  • Headache
  • Constipation
  • Dizziness
  • Trouble sleeping
  • Sweating
  • Dry mouth
  • Sexual dysfunction

In some cases, desvenlafaxine may cause more serious side effects that require immediate medical attention. These include:

  • Serotonin Syndrome: This is a rare but potentially life-threatening condition that can occur when too much serotonin builds up in the body. Symptoms may include agitation, hallucinations, rapid heartbeat, fever, muscle stiffness, tremors, and loss of coordination. If you experience any of these symptoms, seek medical help immediately
  • Allergic reactions: Although rare, some individuals may experience an allergic reaction to desvenlafaxine. Signs of an allergic reaction may include rash, itching, swelling, severe dizziness and trouble breathing

Contact your healthcare provider if you experience any severe or persistent side effects.

Drug interactions

  • Monoamine oxidase inhibitors (MAOIs) are a type of antidepressant that works by inhibiting the activity of monoamine oxidase enzymes, which break down neurotransmitters like serotonin and norepinephrine. Taking desvenlafaxine alongside MAO inhibitors can lead to a dangerous build-up of these neurotransmitters, causing a potentially life-threatening condition known as serotonin syndrome. Therefore, it is crucial to avoid using desvenlafaxine within 14 days of discontinuing an MAOI. The following drugs are MAO inhibitors: isocarboxazid, linezolid, metaxalone, methylene blue, phenelzine, selegiline and tranylcypromine
  • Selective seretonin reuptake inhibitors (SSRIs) such as citalopram, fluoxetine, paroxetine and sertraline, serotonin-norepinephrine reuptake inhibitors (SNRIs) such as duloxetine, triptans, tricyclic antidepressants such as desipramine, and certain pain medications, can also increase the risk of serotonin syndrome
  • Another potential interaction is with drugs that affect bleeding, such as nonsteroidal anti-inflammatory drugs (NSAIDs such as ibuprofen and naproxen) or anticoagulants. Desvenlafaxine can increase the risk of bleeding, so combining it with these medications may heighten the potential for bleeding complications. It is essential to monitor closely for any signs of bleeding if using these medications concurrently with desvenlafaxine
  • Desvenlafaxine may increase the risk of bleeding when taken with anticoagulant medications like warfarin or antiplatelet drugs like aspirin. Regular monitoring of blood clotting parameters may be necessary
  • It is crucial to inform a healthcare professional about all the prescription drugs you are taking, including over-the-counter drugs and supplements, in particular St. John’s Wort to prevent adverse effects



Now Patient has taken all reasonable steps to ensure that all material is factually accurate, complete, and current. However, the knowledge and experience of a qualified healthcare professional should always be sought after instead of using the information in this page. Before taking any drug, you should always speak to your doctor or another qualified healthcare provider.

The information provided here about medications is subject to change and is not meant to include all uses, precautions, warnings, directions, drug interactions, allergic reactions, or negative effects. The absence of warnings or other information for a particular medication does not imply that the medication or medication combination is appropriate for all patients or for all possible purposes.

Stefano Mirabello Medical Reviewer
Pharmacist / B.Pharm
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